公开(公告)号：US20130302901A1

公开(公告)日：2013-11-14

申请号：US13838727

申请日：2013-03-15

申请人： Stuart Lindsay ,  Peiming Zhang ,  Brett Gyarfas ,  Suman Sen ,  Shuai Chang ,  Steven Lefkowitz ,  Hongbo Peng

发明人： Stuart Lindsay ,  Peiming Zhang ,  Brett Gyarfas ,  Suman Sen ,  Shuai Chang ,  Steven Lefkowitz ,  Hongbo Peng

IPC分类号： G01N27/327

CPC分类号： G01N27/3275 ,  G01N33/48721 ,  Y10T156/10 ,  Y10T436/143333

摘要： Some embodiments of the present disclosure provide methods, devices, and systems for sequencing nucleic acid polymers that utilize palladium (Pd), for example, at least in part, as an electrode material that is (i) functionalized with one or more adaptor molecules and (ii) capable for use to sense one or more chemical compositions.

摘要翻译： 本公开的一些实施方案提供了用于测序核酸聚合物的方法，装置和系统，其利用钯（Pd），例如至少部分地作为（i）用一个或多个衔接子分子官能化的电极材料，以及 （ii）能够用于感测一种或多种化学成分。

公开(公告)号：US20190195856A1

公开(公告)日：2019-06-27

申请号：US16327232

申请日：2017-08-21

申请人： Peiming ZHANG ,  Sovan BISWAS ,  Suman SEN ,  Stuart LINDSAY

发明人： Peiming ZHANG ,  Sovan BISWAS ,  Suman SEN ,  Stuart LINDSAY

IPC分类号： G01N33/487 ,  C07C321/10 ,  C12Q1/6869

CPC分类号： G01N33/48721 ,  C07C321/10 ,  C07C2603/50 ,  C12Q1/6869 ,  C12Q2563/116 ,  C12Q2563/157 ,  C12Q2565/607

摘要： The present disclosure provides apparatus and methods for determining the sequence of a nucleic acid. The apparatus comprises electrodes that form a tunnel gap through which the nucleic acid can pass. The electrodes comprise a reagent that is capable of selectively interacting with a nucleobase of the nucleic acid sequence. When the reagent interacts with a nucleobase, a detectable signal is produced and used to identify the nucleobase of the nucleic acid. Advantageously, the apparatus of this disclosure is specific to identifying nucleic acids.