利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

68 条记录 (耗时 0.049 秒)

    Scanning probe with twin-nanopore or a-single-nanopore biomolecules
    4.
    发明授权
    Scanning probe with twin-nanopore or a-single-nanopore biomolecules 有权
    扫描探针与双纳米孔或单纳米孔生物分子

    公开(公告)号：US08821796B2

    公开(公告)日：2014-09-02

    申请号：US13596251

    申请日：2012-08-28

    申请人： Hongbo Peng

    发明人： Hongbo Peng

    IPC分类号： B01L3/02 ,  G01N27/333 ,  G01N33/487

    CPC分类号： G01N27/447 ,  B01L3/02 ,  B01L3/0203 ,  C12Q1/6869 ,  G01N3/12 ,  G01N27/333 ,  G01N33/48721 ,  C12Q2565/631

    摘要： A mechanism is provided for sensing molecules. A twin-nanopore probe includes a first channel and a second channel. A first pressure-controlled reservoir is connected to the first channel to generate a positive pressure. A second pressure-controlled reservoir is connected to the second channel to generate a negative pressure. A container includes ionic solvent with molecules, and a tip of the twin-nanopore probe is submerged in the container of the ionic fluid with the molecules. The first channel, the second channel, the first pressure-controlled reservoir, and the second pressure-controlled reservoir are filled with the ionic fluid. The first pressure-controlled reservoir drives the ionic fluid out of the first channel and the second pressure-controlled reservoir draws in the ionic fluid with the molecules and solvent through the second channel. A flow of ionic current in the twin-nanopore probe is measured to differentiate the molecules that flow through the second channel.

    摘要翻译： 提供了用于感测分子的机制。 双纳米孔探针包括第一通道和第二通道。 第一压力控制的储存器连接到第一通道以产生正压。 第二压力控制的储存器连接到第二通道以产生负压。 容器包括具有分子的离子溶剂，并且双纳米孔探针的尖端被分子浸没在离子流体的容器中。 第一通道，第二通道，第一压力控制储存器和第二压力控制储存器填充有离子流体。 第一压力控制的储存器将离子流体驱出第一通道，而第二压力控制的储存器通过第二通道将分子和溶剂吸附在离子流体中。 测量双纳米孔探针中的离子电流，以区分流过第二通道的分子。

    SCANNING PROBE WITH TWIN-NANOPORE OR A-SINGLE-NANOPORE FOR SENSING BIOMOLECULES
    5.
    发明申请
    SCANNING PROBE WITH TWIN-NANOPORE OR A-SINGLE-NANOPORE FOR SENSING BIOMOLECULES 有权
    用于感应生物分子的扫描探针与双 - 纳米级或单 - 纳米级

    公开(公告)号：US20140053632A1

    公开(公告)日：2014-02-27

    申请号：US13590251

    申请日：2012-08-21

    申请人： Hongbo Peng

    发明人： Hongbo Peng

    IPC分类号： G01N33/48

    CPC分类号： G01N27/447 ,  B01L3/02 ,  B01L3/0203 ,  C12Q1/6869 ,  G01N3/12 ,  G01N27/333 ,  G01N33/48721 ,  C12Q2565/631

    摘要： A mechanism is provided for sensing molecules. A twin-nanopore probe includes a first channel and a second channel. A first pressure-controlled reservoir is connected to the first channel to generate a positive pressure. A second pressure-controlled reservoir is connected to the second channel to generate a negative pressure. A container includes ionic solvent with molecules, and a tip of the twin-nanopore probe is submerged in the container of the ionic fluid with the molecules. The first channel, the second channel, the first pressure-controlled reservoir, and the second pressure-controlled reservoir are filled with the ionic fluid. The first pressure-controlled reservoir drives the ionic fluid out of the first channel and the second pressure-controlled reservoir draws in the ionic fluid with the molecules and solvent through the second channel. A flow of ionic current in the twin-nanopore probe is measured to differentiate the molecules that flow through the second channel.

    摘要翻译： 提供了用于感测分子的机制。 双纳米孔探针包括第一通道和第二通道。 第一压力控制的储存器连接到第一通道以产生正压。 第二压力控制的储存器连接到第二通道以产生负压。 容器包括具有分子的离子溶剂，并且双纳米孔探针的尖端被分子浸没在离子流体的容器中。 第一通道，第二通道，第一压力控制的储存器和第二压力控制的储存器填充有离子流体。 第一压力控制的储存器将离子流体驱出第一通道，而第二压力控制的储存器通过第二通道将分子和溶剂吸附在离子流体中。 测量双纳米孔探针中的离子电流，以区分流过第二通道的分子。

    GRAPHENE TRANSISTOR GATED BY CHARGES THROUGH A NANOPORE FOR BIO-MOLECULAR SENSING AND DNA SEQUENCING
    6.
    发明申请
    GRAPHENE TRANSISTOR GATED BY CHARGES THROUGH A NANOPORE FOR BIO-MOLECULAR SENSING AND DNA SEQUENCING 有权
    用于生物分子传感和DNA测序的纳米级电荷的石墨晶体管

    公开(公告)号：US20130270521A1

    公开(公告)日：2013-10-17

    申请号：US13448509

    申请日：2012-04-17

    申请人： Hongbo Peng ,  Gustavo A. Stolovitzky ,  Wenjuan Zhu

    发明人： Hongbo Peng ,  Gustavo A. Stolovitzky ,  Wenjuan Zhu

    IPC分类号： H01L29/775 ,  B82Y99/00

    CPC分类号： C12Q1/6869 ,  B82Y5/00 ,  G01N33/48721 ,  Y10T436/143333

    摘要： A technique for a nanodevice is provided. A reservoir is separated into two parts by a membrane. A nanopore is formed through the membrane, and the nanopore connects the two parts of the reservoir. The nanopore and the two parts of the reservoir are filled with ionic buffer. The membrane includes a graphene layer and insulating layers. The graphene layer is wired to first and second metal pads to form a graphene transistor in which transistor current flowing through the graphene transistor is modulated by charges passing through the nanopore.

    摘要翻译： 提供了一种纳米设备的技术。 通过膜将储存器分成两部分。 通过膜形成纳米孔，并且纳米孔连接储层的两个部分。 纳米孔和储存器的两个部分填充有离子缓冲液。 膜包括石墨烯层和绝缘层。 石墨烯层连接到第一和第二金属焊盘以形成石墨烯晶体管，其中流过石墨烯晶体管的晶体管电流通过穿过纳米孔的电荷进行调制。

    CHARGED ENTITIES AS LOCOMOTIVE TO CONTROL MOTION OF POLYMERS THROUGH A NANOCHANNEL
    7.
    发明申请
    CHARGED ENTITIES AS LOCOMOTIVE TO CONTROL MOTION OF POLYMERS THROUGH A NANOCHANNEL 有权
    充电实体通过纳米通道控制聚合物的运动

    公开(公告)号：US20130068618A1

    公开(公告)日：2013-03-21

    申请号：US13611662

    申请日：2012-09-12

    申请人： Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  George F. Walker

    发明人： Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  George F. Walker

    IPC分类号： C25B15/00 ,  B82Y30/00

    CPC分类号： B82Y15/00 ,  C12Q1/6869 ,  C12Q2565/631

    摘要： A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.

    摘要翻译： 提供了一种用于控制通过纳米通道连接到聚合物的一个或多个带电实体的运动的技术。 第一储存器和第二储存器通过纳米通道连接。 电极阵列沿纳米通道定位，其中流体填充第一储存器，第二储存器和纳米通道。 第一电极在第一储存器中，第二电极位于第二储存器中。 第一和第二电极被配置为将连接到聚合物的一个或多个带电实体引导到纳米通道中。 电极阵列被配置为捕捉纳米通道中的一个或多个带电实体，以响应于被捕获而被控制。 电极阵列被配置为响应于被控制移动而沿着纳米通道移动一个或多个带电实体。