公开(公告)号：US08686028B2

公开(公告)日：2014-04-01

申请号：US13127913

申请日：2009-05-14

Applicant: Atul Goel ,  Amit Kumar ,  Sumit Chaurasia ,  Divya Singh ,  Abnish Kumar Gautam ,  Rashmi Pandey ,  Ritu Trivedi ,  Man Mohan Singh ,  Naibedya Chattopadhyay ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Anil Kumar Dwivedi

Inventor： Atul Goel ,  Amit Kumar ,  Sumit Chaurasia ,  Divya Singh ,  Abnish Kumar Gautam ,  Rashmi Pandey ,  Ritu Trivedi ,  Man Mohan Singh ,  Naibedya Chattopadhyay ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Anil Kumar Dwivedi

IPC: A61K31/352 ,  A61K31/4453 ,  C07D311/36 ,  C07D493/04

CPC classification number: C07D493/04 ,  C07D311/36

Abstract: The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted pyran; or may be connected through a methylenedeoxy moiety; wherein X is selected from the units consisting of optionally a ketone group, optionally a methylene group, optionally substituted methylene group, optionally substituted alkene; wherein Y and Z is selected from the units consisting of CH, C—OH, C-Me, C—OMe with the proviso that bond between Y and Z is a single bond; Wherein Y and Z may be a carbon atom with the proviso that bond between Y and Z is a double bond. The compounds of the general formula is useful for the prevention and treatment of bone related disorders.

Abstract translation: 本发明涉及具有通式（I）的新型取代的苯并呋喃和其相关化合物，其盐和手性的非手性衍生物; 其中R1，R2，R3，R4，R5，R6，R7，R8独立地选自氢，任选取代的烷基，任选取代的烯基，任选取代的烷氧基，任选取代的芳基，任选取代的杂芳基，任选取代的烷硫基， 任选取代的氨基，任选取代的酰基氨基，任选取代的芳基氨基，任选取代的酰基硫基，任选取代的酰基，任选取代的芳酰基，任选取代的酰氧基，任选取代的硫代酰氨基，卤素，腈，酯，羟基，巯基，三氟化碳，硝基，但不限于此 ; 其中R1R2或R2R3或R6R7可以连接并形成五元环或六元环，例如任选取代的呋喃，任选取代的二氢呋喃，任选取代的吡喃; 或可以通过亚甲二氧基部分连接; 其中X选自由任选的酮基，任选的亚甲基，任选取代的亚甲基，任选取代的烯烃组成的单元; 其中Y和Z选自由CH，C-OH，C-Me，C-OMe组成的单元，条件是Y和Z之间的键是单键; 其中Y和Z可以是碳原子，条件是Y和Z之间的键是双键。 通式的化合物可用于预防和治疗骨相关疾病。

公开(公告)号：US08946682B2

公开(公告)日：2015-02-03

申请号：US12894428

申请日：2010-09-30

Applicant: Atul Goel ,  Sumit Chaurasia ,  Vijay Kumar ,  Sundar Manoharan ,  R. S. Anand

Inventor： Atul Goel ,  Sumit Chaurasia ,  Vijay Kumar ,  Sundar Manoharan ,  R. S. Anand

IPC: H01L29/08 ,  C07D295/155 ,  C07D207/327 ,  C07D211/14 ,  C07D307/54 ,  C07D333/24 ,  H01L51/00

CPC classification number: C07D295/155 ,  C07D207/327 ,  C07D211/14 ,  C07D307/54 ,  C07D333/24 ,  H01L51/0058 ,  Y02E10/549 ,  Y02P70/521

Abstract: The present invention relates to novel donor-acceptor fluorene compounds, which can be used as for the fabrication of electroluminescent devices, and a process of preparing said novel compounds. More particularly, the present invention relates to amine donor and nitrile/ester acceptor fluorenes, fluorenones their π-conjugated systems and related compounds, processes for preparing the said compounds including oxidation of fluorenes to corresponding fluorenones and their use in preparing organic electronic devices such as organic light emitting diodes (OLEDs), photovoltaic/solar cell, Field effect transistors and other useful electroluminescent devices. The compounds are prepared by reacting 2H-pyran-2-ones in isolated or rigid conformations with cyclic ketones containing methylene carbonyl moiety in the presence of a base in an organic solvent. The present invention also relates to a new concept and approach to overcome the problem of ‘Green emission defect’ in 9-unsubstituted fluorene-based organic light emitting diodes which occurs due to the conversion of fluorenes to fluorenones that show emission mainly in green-yellow region. In the present invention we have placed donor-acceptor substituents in such a way that donor-acceptor fluorenones show emission in the blue region (instead of green-yellow region) thus improving the blue color purity and overcoming the problem of green emission defect.

Abstract translation: 本发明涉及可用于制造电致发光器件的新型供体 - 受体芴化合物，以及制备所述新型化合物的方法。 更具体地，本发明涉及胺供体和腈/酯受体芴，芴酮及其共轭体系和相关化合物，制备所述化合物的方法，包括将芴氧化成相应的芴酮及其在制备有机电子器件中的用途， 作为有机发光二极管（OLED），光伏/太阳能电池，场效应晶体管等有用的电致发光器件。 通过在有机溶剂中的碱存在下，将分离或刚性构象中的2H-吡喃-2-酮与含有亚甲基羰基部分的环酮反应制备化合物。 本发明还涉及克服9-未取代的基于芴的有机发光二极管中由于将芴转化为芴酮而发生的“绿色发光缺陷”的新概念和方法，其显示主要以绿黄色 地区。 在本发明中，我们以供体 - 受体芴酮在蓝色区域（而不是绿 - 黄色区域）中显示发射的方式放置了供体 - 受体取代基，从而提高了蓝色纯度并克服了绿色发光缺陷的问题。

公开(公告)号：US20110210315A1

公开(公告)日：2011-09-01

申请号：US12894428

申请日：2010-09-30

Applicant: Atul GOEL ,  Sumit CHAURASIA ,  Vijay KUMAR ,  Sundar MANOHARAN ,  R.S. ANAND

Inventor： Atul GOEL ,  Sumit CHAURASIA ,  Vijay KUMAR ,  Sundar MANOHARAN ,  R.S. ANAND

IPC: H01L51/54 ,  C07D295/155 ,  C07D211/06

CPC classification number: C07D295/155 ,  C07D207/327 ,  C07D211/14 ,  C07D307/54 ,  C07D333/24 ,  H01L51/0058 ,  Y02E10/549 ,  Y02P70/521

Abstract: The present invention relates to novel donor-acceptor fluorene compounds, which can be used as for the fabrication of electroluminescent devices, and a process of preparing said novel compounds. More particularly, the present invention relates to amine donor and nitrile/ester acceptor fluorenes, fluorenones their π-conjugated systems and related compounds, processes for preparing the said compounds including oxidation of fluorenes to corresponding fluorenones and their use in preparing organic electronic devices such as organic light emitting diodes (OLEDs), photovoltaic/solar cell, Field effect transistors and other useful electroluminescent devices. The compounds are prepared by reacting 2H-pyran-2-ones in isolated or rigid conformations with cyclic ketones containing methylene carbonyl moiety in the presence of a base in an organic solvent. The present invention also relates to a new concept and approach to overcome the problem of ‘Green emission defect’ in 9-unsubstituted fluorene-based organic light emitting diodes which occurs due to the conversion of fluorenes to fluorenones that show emission mainly in green-yellow region. In the present invention we have placed donor-acceptor substituents in such a way that donor-acceptor fluorenones show emission in the blue region (instead of green-yellow region) thus improving the blue colour purity and overcoming the problem of green emission defect.

Abstract translation: 本发明涉及可用于制造电致发光器件的新型供体 - 受体芴化合物，以及制备所述新型化合物的方法。 更具体地，本发明涉及胺供体和腈/酯受体芴，芴酮及其共轭体系和相关化合物，制备所述化合物的方法，包括将芴氧化成相应的芴酮及其在制备有机电子器件中的用途， 作为有机发光二极管（OLED），光伏/太阳能电池，场效应晶体管等有用的电致发光器件。 通过在有机溶剂中的碱存在下，将分离或刚性构象中的2H-吡喃-2-酮与含有亚甲基羰基部分的环酮反应制备化合物。 本发明还涉及克服9-未取代的基于芴的有机发光二极管中由于将芴转化为芴酮而发生的“绿色发光缺陷”的新概念和方法，其显示主要以绿黄色 地区。 在本发明中，我们以供体 - 受体芴酮在蓝色区域（而不是绿 - 黄色区域）中显示发射的方式放置了供体 - 受体取代基，从而提高了蓝色纯度并克服了绿色发光缺陷的问题。

公开(公告)号：US20120003273A1

公开(公告)日：2012-01-05

申请号：US13127913

申请日：2009-05-14

Applicant: Atul Goel ,  Amit Kumar ,  Sumit Chaurasia ,  Divya Singh ,  Abnish Kumar Gautam ,  Rashmi Pandey ,  Ritu Trivedi ,  Man Mohan Singh ,  Naibedya Chattopadhyay ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Anil Kumar Dwivedi

Inventor： Atul Goel ,  Amit Kumar ,  Sumit Chaurasia ,  Divya Singh ,  Abnish Kumar Gautam ,  Rashmi Pandey ,  Ritu Trivedi ,  Man Mohan Singh ,  Naibedya Chattopadhyay ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Anil Kumar Dwivedi

IPC: A61K31/352 ,  C07D311/36 ,  A61P19/08 ,  A61K31/4453 ,  A61P19/10 ,  C07D493/04 ,  A61K9/00

CPC classification number: C07D493/04 ,  C07D311/36

Abstract: The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted pyran; or may be connected through a methylenedeoxy moiety; wherein X is selected from the units consisting of optionally a ketone group, optionally a methylene group, optionally substituted methylene group, optionally substituted alkene; wherein Y and Z is selected from the units consisting of CH, C—OH, C-Me, C—OMe with the proviso that bond between Y and Z is a single bond; Wherein Y and Z may be a carbon atom with the proviso that bond between Y and Z is a double bond. The compounds of the general formula is useful for the prevention and treatment of bone related disorders.

Abstract translation: 本发明涉及具有通式（I）的新型取代的苯并呋喃和其相关化合物，其盐和手性的非手性衍生物; 其中R1，R2，R3，R4，R5，R6，R7，R8独立地选自氢，任选取代的烷基，任选取代的烯基，任选取代的烷氧基，任选取代的芳基，任选取代的杂芳基，任选取代的烷硫基， 任选取代的氨基，任选取代的酰基氨基，任选取代的芳基氨基，任选取代的酰基硫基，任选取代的酰基，任选取代的芳酰基，任选取代的酰氧基，任选取代的硫代酰氨基，卤素，腈，酯，羟基，巯基，三氟化碳，硝基，但不限于此 ; 其中R1R2或R2R3或R6R7可以连接并形成五元环或六元环，例如任选取代的呋喃，任选取代的二氢呋喃，任选取代的吡喃; 或可以通过亚甲二氧基部分连接; 其中X选自由任选的酮基，任选的亚甲基，任选取代的亚甲基，任选取代的烯烃组成的单元; 其中Y和Z选自由CH，C-OH，C-Me，C-OMe组成的单元，条件是Y和Z之间的键是单键; 其中Y和Z可以是碳原子，条件是Y和Z之间的键是双键。 通式的化合物可用于预防和治疗骨相关疾病。