公开(公告)号：US08686028B2

公开(公告)日：2014-04-01

申请号：US13127913

申请日：2009-05-14

申请人： Atul Goel ,  Amit Kumar ,  Sumit Chaurasia ,  Divya Singh ,  Abnish Kumar Gautam ,  Rashmi Pandey ,  Ritu Trivedi ,  Man Mohan Singh ,  Naibedya Chattopadhyay ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Anil Kumar Dwivedi

发明人： Atul Goel ,  Amit Kumar ,  Sumit Chaurasia ,  Divya Singh ,  Abnish Kumar Gautam ,  Rashmi Pandey ,  Ritu Trivedi ,  Man Mohan Singh ,  Naibedya Chattopadhyay ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Anil Kumar Dwivedi

IPC分类号： A61K31/352 ,  A61K31/4453 ,  C07D311/36 ,  C07D493/04

CPC分类号： C07D493/04 ,  C07D311/36

摘要： The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted pyran; or may be connected through a methylenedeoxy moiety; wherein X is selected from the units consisting of optionally a ketone group, optionally a methylene group, optionally substituted methylene group, optionally substituted alkene; wherein Y and Z is selected from the units consisting of CH, C—OH, C-Me, C—OMe with the proviso that bond between Y and Z is a single bond; Wherein Y and Z may be a carbon atom with the proviso that bond between Y and Z is a double bond. The compounds of the general formula is useful for the prevention and treatment of bone related disorders.

摘要翻译： 本发明涉及具有通式（I）的新型取代的苯并呋喃和其相关化合物，其盐和手性的非手性衍生物; 其中R1，R2，R3，R4，R5，R6，R7，R8独立地选自氢，任选取代的烷基，任选取代的烯基，任选取代的烷氧基，任选取代的芳基，任选取代的杂芳基，任选取代的烷硫基， 任选取代的氨基，任选取代的酰基氨基，任选取代的芳基氨基，任选取代的酰基硫基，任选取代的酰基，任选取代的芳酰基，任选取代的酰氧基，任选取代的硫代酰氨基，卤素，腈，酯，羟基，巯基，三氟化碳，硝基，但不限于此 ; 其中R1R2或R2R3或R6R7可以连接并形成五元环或六元环，例如任选取代的呋喃，任选取代的二氢呋喃，任选取代的吡喃; 或可以通过亚甲二氧基部分连接; 其中X选自由任选的酮基，任选的亚甲基，任选取代的亚甲基，任选取代的烯烃组成的单元; 其中Y和Z选自由CH，C-OH，C-Me，C-OMe组成的单元，条件是Y和Z之间的键是单键; 其中Y和Z可以是碳原子，条件是Y和Z之间的键是双键。 通式的化合物可用于预防和治疗骨相关疾病。

公开(公告)号：US20120003273A1

公开(公告)日：2012-01-05

申请号：US13127913

申请日：2009-05-14

申请人： Atul Goel ,  Amit Kumar ,  Sumit Chaurasia ,  Divya Singh ,  Abnish Kumar Gautam ,  Rashmi Pandey ,  Ritu Trivedi ,  Man Mohan Singh ,  Naibedya Chattopadhyay ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Anil Kumar Dwivedi

发明人： Atul Goel ,  Amit Kumar ,  Sumit Chaurasia ,  Divya Singh ,  Abnish Kumar Gautam ,  Rashmi Pandey ,  Ritu Trivedi ,  Man Mohan Singh ,  Naibedya Chattopadhyay ,  Lakshmi Manickavasagam ,  Girish Kumar Jain ,  Anil Kumar Dwivedi

IPC分类号： A61K31/352 ,  C07D311/36 ,  A61P19/08 ,  A61K31/4453 ,  A61P19/10 ,  C07D493/04 ,  A61K9/00

CPC分类号： C07D493/04 ,  C07D311/36

摘要： The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted pyran; or may be connected through a methylenedeoxy moiety; wherein X is selected from the units consisting of optionally a ketone group, optionally a methylene group, optionally substituted methylene group, optionally substituted alkene; wherein Y and Z is selected from the units consisting of CH, C—OH, C-Me, C—OMe with the proviso that bond between Y and Z is a single bond; Wherein Y and Z may be a carbon atom with the proviso that bond between Y and Z is a double bond. The compounds of the general formula is useful for the prevention and treatment of bone related disorders.

摘要翻译： 本发明涉及具有通式（I）的新型取代的苯并呋喃和其相关化合物，其盐和手性的非手性衍生物; 其中R1，R2，R3，R4，R5，R6，R7，R8独立地选自氢，任选取代的烷基，任选取代的烯基，任选取代的烷氧基，任选取代的芳基，任选取代的杂芳基，任选取代的烷硫基， 任选取代的氨基，任选取代的酰基氨基，任选取代的芳基氨基，任选取代的酰基硫基，任选取代的酰基，任选取代的芳酰基，任选取代的酰氧基，任选取代的硫代酰氨基，卤素，腈，酯，羟基，巯基，三氟化碳，硝基，但不限于此 ; 其中R1R2或R2R3或R6R7可以连接并形成五元环或六元环，例如任选取代的呋喃，任选取代的二氢呋喃，任选取代的吡喃; 或可以通过亚甲二氧基部分连接; 其中X选自由任选的酮基，任选的亚甲基，任选取代的亚甲基，任选取代的烯烃组成的单元; 其中Y和Z选自由CH，C-OH，C-Me，C-OMe组成的单元，条件是Y和Z之间的键是单键; 其中Y和Z可以是碳原子，条件是Y和Z之间的键是双键。 通式的化合物可用于预防和治疗骨相关疾病。

公开(公告)号：US08946682B2

公开(公告)日：2015-02-03

申请号：US12894428

申请日：2010-09-30

申请人： Atul Goel ,  Sumit Chaurasia ,  Vijay Kumar ,  Sundar Manoharan ,  R. S. Anand

发明人： Atul Goel ,  Sumit Chaurasia ,  Vijay Kumar ,  Sundar Manoharan ,  R. S. Anand

IPC分类号： H01L29/08 ,  C07D295/155 ,  C07D207/327 ,  C07D211/14 ,  C07D307/54 ,  C07D333/24 ,  H01L51/00

CPC分类号： C07D295/155 ,  C07D207/327 ,  C07D211/14 ,  C07D307/54 ,  C07D333/24 ,  H01L51/0058 ,  Y02E10/549 ,  Y02P70/521

摘要： The present invention relates to novel donor-acceptor fluorene compounds, which can be used as for the fabrication of electroluminescent devices, and a process of preparing said novel compounds. More particularly, the present invention relates to amine donor and nitrile/ester acceptor fluorenes, fluorenones their π-conjugated systems and related compounds, processes for preparing the said compounds including oxidation of fluorenes to corresponding fluorenones and their use in preparing organic electronic devices such as organic light emitting diodes (OLEDs), photovoltaic/solar cell, Field effect transistors and other useful electroluminescent devices. The compounds are prepared by reacting 2H-pyran-2-ones in isolated or rigid conformations with cyclic ketones containing methylene carbonyl moiety in the presence of a base in an organic solvent. The present invention also relates to a new concept and approach to overcome the problem of ‘Green emission defect’ in 9-unsubstituted fluorene-based organic light emitting diodes which occurs due to the conversion of fluorenes to fluorenones that show emission mainly in green-yellow region. In the present invention we have placed donor-acceptor substituents in such a way that donor-acceptor fluorenones show emission in the blue region (instead of green-yellow region) thus improving the blue color purity and overcoming the problem of green emission defect.

摘要翻译： 本发明涉及可用于制造电致发光器件的新型供体 - 受体芴化合物，以及制备所述新型化合物的方法。 更具体地，本发明涉及胺供体和腈/酯受体芴，芴酮及其共轭体系和相关化合物，制备所述化合物的方法，包括将芴氧化成相应的芴酮及其在制备有机电子器件中的用途， 作为有机发光二极管（OLED），光伏/太阳能电池，场效应晶体管等有用的电致发光器件。 通过在有机溶剂中的碱存在下，将分离或刚性构象中的2H-吡喃-2-酮与含有亚甲基羰基部分的环酮反应制备化合物。 本发明还涉及克服9-未取代的基于芴的有机发光二极管中由于将芴转化为芴酮而发生的“绿色发光缺陷”的新概念和方法，其显示主要以绿黄色 地区。 在本发明中，我们以供体 - 受体芴酮在蓝色区域（而不是绿 - 黄色区域）中显示发射的方式放置了供体 - 受体取代基，从而提高了蓝色纯度并克服了绿色发光缺陷的问题。

公开(公告)号：US12064147B2

公开(公告)日：2024-08-20

申请号：US17672291

申请日：2022-02-15

申请人： Atul Goel

发明人： Atul Goel

IPC分类号： A61B17/70 ,  A61B17/17 ,  A61F2/44 ,  A61F2/46 ,  A61F2/30

CPC分类号： A61B17/7064 ,  A61B17/1757 ,  A61B17/7044 ,  A61B17/7065 ,  A61F2/4425 ,  A61F2/446 ,  A61F2/4465 ,  A61F2/447 ,  A61F2/4611 ,  A61B17/7059 ,  A61F2002/30131 ,  A61F2002/30143 ,  A61F2002/30169 ,  A61F2002/30172 ,  A61F2002/30197 ,  A61F2002/30331 ,  A61F2002/30364 ,  A61F2002/30578 ,  A61F2002/30593 ,  A61F2002/30649 ,  A61F2002/30662 ,  A61F2002/30772 ,  A61F2002/30774 ,  A61F2002/30782 ,  A61F2002/3079 ,  A61F2002/308 ,  A61F2002/30808 ,  A61F2002/30836 ,  A61F2002/30841 ,  A61F2002/3085 ,  A61F2002/30904 ,  A61F2/4405 ,  A61F2/4603 ,  A61F2002/4627 ,  A61F2002/4629

摘要： A vertebral facet distractor includes an elongated generally cylindrical contour including a first end surface, a second end surface, an outer sidewall, an inner sidewall, and a central lumen having an opening in one of the first end surface and the second end surface. The outer sidewall may be provided with a surface irregularity, such as a screw thread. The vertebral facet distractor may further include a holder including an elongated body and a tip that extends through the opening and is engaged with the contour. The tip may be provided with a screw thread that is engaged with the contour or may engage the contour in an interference fit.

公开(公告)号：US08595595B1

公开(公告)日：2013-11-26

申请号：US12979130

申请日：2010-12-27

申请人： Tomislav Grcanac ,  Atul Goel ,  Jagadish Vasudeva ,  Gururaj MJ

发明人： Tomislav Grcanac ,  Atul Goel ,  Jagadish Vasudeva ,  Gururaj MJ

IPC分类号： G11C29/00

CPC分类号： G06F11/1088 ,  G06F11/1092 ,  G06F2211/104 ,  G06F2211/1088

摘要： A storage server stores data in a stripe of a parity group that includes a plurality of data storage devices to store data and a parity storage device to store parity information. The stripe includes a data block from each of the data storage devices and a parity block from the parity storage device. The storage server receives a data access request specifying a data block in the stripe, and a lost write detection module detects an error in the data block. The lost write detection module compares a first storage device signature stored in a metadata field associated with the data block to a second storage device signature stored in a global field of the data storage device containing the data block. If the first storage device signature matches the second storage device signature, the lost write detection module compares a consistency point count stored in the metadata field to a reconstructed consistency point count. If the reconstructed consistency point count is greater than the consistency point count stored in the metadata field, the lost write detection module identifies the error as a lost write error for the data block. Accurately detecting and identifying the location of a lost write allows the storage server to correct the error and provide a user with a complete and accurate set of data.

摘要翻译： 存储服务器将数据存储在包括多个数据存储设备的奇偶校验组的条带中以存储数据，并且奇偶校验存储设备存储奇偶校验信息。 条带包括来自每个数据存储设备的数据块和来自奇偶校验存储设备的奇偶校验块。 存储服务器接收指定条带中的数据块的数据访问请求，并且丢失写入检测模块检测数据块中的错误。 丢失的写入检测模块将存储在与数据块相关联的元数据字段中的第一存储设备签名与存储在包含数据块的数据存储设备的全局字段中的第二存储设备签名进行比较。 如果第一存储设备签名与第二存储设备签名匹配，则丢失写入检测模块将存储在元数据字段中的一致性点数与重建的一致性点数进行比较。 如果重建的一致性点数大于存储在元数据字段中的一致性点数，则丢失的写入检测模块将错误识别为数据块的丢失写入错误。 准确检测和识别丢失写入的位置允许存储服务器纠正错误，并为用户提供完整和准确的数据集。

公开(公告)号：US08429514B1

公开(公告)日：2013-04-23

申请号：US12237138

申请日：2008-09-24

申请人： Atul Goel

发明人： Atul Goel

IPC分类号： G11C29/42 ,  G11C29/56

CPC分类号： G06F12/00 ,  G06F11/1076 ,  G06F2211/1028

摘要： A parity pattern defines a repeated distribution of parity blocks within a distributed parity disk array (“DPDA”). The parity pattern identifies on which disks the parity block or blocks for a stripe are located. When a new disk is added to the DPDA, the parity pattern is modified so that the distribution of parity blocks within the parity pattern is even. Parity blocks within the DPDA are then redistributed to conform with the modified parity pattern.

摘要翻译： 奇偶校验模式定义了分布式奇偶校验磁盘阵列（“DPDA”）内奇偶校验块的重复分布。 奇偶校验模式标识了条带的奇偶校验块或块所在的磁盘。 当新的磁盘被添加到DPDA时，奇偶校验模式被修改，使得奇偶校验模式内的奇偶校验块的分布是均匀的。 然后将DPDA中的奇偶校验块重新分配，以符合修改的奇偶校验模式。

公开(公告)号：US08402346B2

公开(公告)日：2013-03-19

申请号：US12536063

申请日：2009-09-25

申请人： Atul Goel ,  Peter F. Corbett

发明人： Atul Goel ,  Peter F. Corbett

IPC分类号： G11C29/00

CPC分类号： G06F11/1076

摘要： An n-way parity protection technique enables recovery of up to n storage device (e.g., disk) failures in a parity group of a storage array encoded to protect against n-way disk failures. The storage array is created by first configuring the array with m data disks, where m=p−1 and p is a prime number and a row parity disk. n−1 diagonal parity disks are then added to the array. Each diagonal parity set (i.e., diagonal) is associated with a slope that defines the data and row parity blocks of the array that are included in the diagonal. All diagonals having a common slope within a parity group are organized as a diagonal parity class. For each diagonal parity class, a diagonal parity storage disk is provided to store the diagonal parity.

摘要翻译： n路奇偶校验保护技术使得能够恢复存储阵列的奇偶校验组中的多达n个存储设备（例如，磁盘）故障，其被编码以防止n路盘故障。 存储阵列是通过首先使用m个数据磁盘配置阵列创建的，其中m = p-1，p是素数和行奇偶校验磁盘。 然后将n-1个对角线奇偶校验磁盘添加到阵列中。 每个对角奇偶校验集（即对角线）与定义包括在对角线中的阵列的数据和行奇偶校验块的斜率相关联。 在奇偶校验组内具有公共斜率的所有对角线被组织为对角奇偶校验类。 对于每个对角奇偶校验类，提供对角奇偶校验存储盘以存储对角奇偶校验。

公开(公告)号：US08369555B2

公开(公告)日：2013-02-05

申请号：US11588752

申请日：2006-10-27

申请人： R. Shane Fazzio ,  Atul Goel

发明人： R. Shane Fazzio ,  Atul Goel

IPC分类号： H04R25/00

CPC分类号： H04R3/005 ,  H04R3/04 ,  H04R17/02 ,  H04R19/005 ,  H04R19/016 ,  H04R31/00 ,  H04R2410/05 ,  H04R2499/11

摘要： Electronic devices and microphone devices are described.

摘要翻译： 描述电子设备和麦克风设备。

公开(公告)号：US08275939B2

公开(公告)日：2012-09-25

申请号：US13310252

申请日：2011-12-02

申请人： Ratnesh Gupta ,  James Leong ,  Atul Goel

发明人： Ratnesh Gupta ,  James Leong ,  Atul Goel

IPC分类号： G06F11/14 ,  G06F12/00 ,  G06F13/00

CPC分类号： G06F11/1435

摘要： Storage servers use a fast, non-volatile or persistent memory to store data until it can be written to slower mass storage devices such as disk drives. If the server crashes before a write can complete, the data remains safely stored in non-volatile memory. If the data cannot be committed to disk when the server reboots (e.g. because the destination mass storage device is unavailable), it is stored in a file. When the disk reappears, the data in the file may be used to restore a file or filesystem on the disk to a consistent state.

摘要翻译： 存储服务器使用快速，非易失性或永久性存储器来存储数据，直到它可以写入较慢的大容量存储设备（如磁盘驱动器）。 如果服务器在写入完成之前崩溃，数据将保持安全地存储在非易失性存储器中。 如果服务器重新启动（例如由于目标大容量存储设备不可用）而无法将数据提交到磁盘，则将其存储在文件中。 当磁盘重新出现时，文件中的数据可能用于将磁盘上的文件或文件系统还原到一致状态。

公开(公告)号：US08099623B1

公开(公告)日：2012-01-17

申请号：US12247877

申请日：2008-10-08

申请人： Yan Li ,  Atul Goel

发明人： Yan Li ,  Atul Goel

IPC分类号： G06F11/00

CPC分类号： G06F11/1084 ,  G06F11/1092 ,  G06F11/2094 ,  G06F2211/1011

摘要： A network storage server implements a method to maintain a parity declustered RAID organization with distributed hot sparing. The parity declustered RAID organization, which provides data redundancy for a network storage system, is configured as a RAID organization with a plurality of logical drives. The RAID organization is then distributed in a parity declustered fashion to a plurality of physical drives in the network storage system. The RAID organization also has a spare space pre-allocating on each of the plurality of physical drives. Upon failure of one of the plurality of physical drives, data stored in the failed physical drives can be reconstructed and stored to spare space of the surviving physical drives. After reconstruction, the plurality of logical drives remains parity-declustered on the plurality of surviving physical drives.

摘要翻译： 网络存储服务器实现一种方法来维护具有分布式热备份的奇偶校验分簇RAID组织。 为网络存储系统提供数据冗余的奇偶校验分簇RAID组织被配置为具有多个逻辑驱动器的RAID组织。 然后，RAID组织以奇偶校验方式分发到网络存储系统中的多个物理驱动器。 RAID组织还具有在多个物理驱动器中的每一个上预先分配的备用空间。 在多个物理驱动器中的一个发生故障时，存储在故障物理驱动器中的数据可以被重建和存储以存储幸存的物理驱动器的空间。 在重建之后，多个逻辑驱动器在多个幸存的物理驱动器上保持奇偶校验解聚。