公开(公告)号：US06670450B1

公开(公告)日：2003-12-30

申请号：US09684579

申请日：2000-10-06

申请人： Renu Wadhwa ,  Sunil C. Kaul ,  Roger R. Reddel

发明人： Renu Wadhwa ,  Sunil C. Kaul ,  Roger R. Reddel

IPC分类号： C07K100

CPC分类号： C07K14/4703 ,  A61K38/00 ,  C07K16/18

摘要： A gene was unexpectedly isolated in an attempt to isolate a gene specifically expressed in immortalized cells via antibody screening using an antibody raised against a protein occurring specifically in immortalized cells. The gene thus isolated shares no sequence homology with the entries deposited in the database and was strongly expressed in skeletal muscles and undifferentiated cells. The protein encoded by this gene inhibits the differentiation of myoblasts into myotubes. It also inhibits the transactivation function of p53, a transcription factor involved in tumor suppression.

摘要翻译： 试图通过使用针对在永生化细胞中特异性发生的蛋白产生的抗体通过抗体筛选来分离在永生化细胞中特异性表达的基因的基因。 这样分离的基因与保藏在数据库中的条目没有序列同源性，并且在骨骼肌和未分化细胞中强烈表达。 由该基因编码的蛋白质抑制成肌细胞分化成肌管。 它还抑制参与肿瘤抑制的转录因子p53的反式激活功能。

公开(公告)号：US07288635B2

公开(公告)日：2007-10-30

申请号：US11192374

申请日：2005-07-29

申请人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

发明人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

IPC分类号： C07K16/18

CPC分类号： C07K14/4702

摘要： A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis and to encode a protein, Tesmin, which may regulate the differentiation of spermatogeneous cells into primary spermatocytes. Tesmin proteins are described herein, as are antibodies that bind to such proteins.

摘要翻译： 在研究编码引发细胞死亡的未知蛋白质的基因的表达过程中，已经意外地分离了在睾丸中特异表达的基因。 分离的基因是一个新的基因序列，在数据库中没有显着的同源物。 该基因也被发现参与睾丸分化的调节和编码一种蛋白质Tesmin，其可以调节精原细胞分化为原始精母细胞。 本文描述了Tesmin蛋白质，以及与这些蛋白质结合的抗体。

公开(公告)号：US06835813B1

公开(公告)日：2004-12-28

申请号：US09743237

申请日：2001-06-04

申请人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

发明人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

IPC分类号： C07K1447

CPC分类号： C07K14/4702

摘要： A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis.

摘要翻译： 在研究编码引发细胞死亡的未知蛋白质的基因的表达过程中，已经意外地分离了在睾丸中特异表达的基因。 分离的基因是一个新的基因序列，在数据库中没有显着的同源物。 该基因也被发现参与睾丸分化的调节。

公开(公告)号：US06949364B2

公开(公告)日：2005-09-27

申请号：US10876841

申请日：2004-06-28

申请人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

发明人： Takashi Sugihara ,  Renu Wadhwa ,  Sunil C. Kaul ,  Youji Mitsui

IPC分类号： C07K14/47 ,  C12N15/09 ,  C12N15/12 ,  C12P21/06 ,  C12P21/02 ,  C07H21/04 ,  C12N5/10 ,  C12N15/63

CPC分类号： C07K14/4702

摘要： A gene expressed specifically in the testis has been unexpectedly isolated in the course of studies of the expression of a gene encoding an unknown protein that triggers cell death. The isolated gene was a novel gene sequence that had no significant homologue in the database. This gene was also found to be involved in the regulation of differentiation in the testis.

摘要翻译： 在研究编码引发细胞死亡的未知蛋白质的基因的表达过程中，已经意外地分离了在睾丸中特异表达的基因。 分离的基因是一个新的基因序列，在数据库中没有显着的同源物。 该基因也被发现参与睾丸分化的调节。