公开(公告)号：US20050169979A1

公开(公告)日：2005-08-04

申请号：US11036690

申请日：2005-01-14

申请人： Dov Michaeli ,  Stephen Grimes ,  Yechezkel Barenholz ,  Simcha Even-Chen ,  Susan Hagan

发明人： Dov Michaeli ,  Stephen Grimes ,  Yechezkel Barenholz ,  Simcha Even-Chen ,  Susan Hagan

IPC分类号： A61K9/127 ,  A61K39/00 ,  C12N5/02 ,  C12N15/88

CPC分类号： A61K9/127 ,  A61K38/09 ,  A61K38/2207 ,  A61K38/27

摘要： The invention provides liposomal vehicles for encapsulating relatively high levels of immunogenic protein substances including immunogens directed against hormones and hormone receptors, such as gastrin and gonadotropin releasing hormone and their receptors. The liposome encapsulating large amounts of immunogens can be injected parenterally to induce effective immune responses without exhibiting significant adverse tissue reactogenicity. Methods for production of the liposomal vaccines and methods of their administration for treatment of diseases and conditions associated with the cognate hormones are also provided.

摘要翻译： 本发明提供用于包封相对高水平的免疫原性蛋白质物质的脂质体载体，包括针对激素和激素受体的免疫原，例如胃泌素和促性腺激素释放激素及其受体。 包封大量免疫原的脂质体可以肠胃外注射以诱导有效的免疫应答，而不显示显着的不利组织反应原性。 还提供了用于生产脂质体疫苗的方法及其用于治疗与同类激素相关的疾病和病症的施用方法。