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公开(公告)号：US20050169979A1
公开(公告)日：2005-08-04
申请号：US11036690
申请日：2005-01-14
CPC分类号： A61K9/127 , A61K38/09 , A61K38/2207 , A61K38/27
摘要： The invention provides liposomal vehicles for encapsulating relatively high levels of immunogenic protein substances including immunogens directed against hormones and hormone receptors, such as gastrin and gonadotropin releasing hormone and their receptors. The liposome encapsulating large amounts of immunogens can be injected parenterally to induce effective immune responses without exhibiting significant adverse tissue reactogenicity. Methods for production of the liposomal vaccines and methods of their administration for treatment of diseases and conditions associated with the cognate hormones are also provided.
摘要翻译： 本发明提供用于包封相对高水平的免疫原性蛋白质物质的脂质体载体，包括针对激素和激素受体的免疫原，例如胃泌素和促性腺激素释放激素及其受体。 包封大量免疫原的脂质体可以肠胃外注射以诱导有效的免疫应答，而不显示显着的不利组织反应原性。 还提供了用于生产脂质体疫苗的方法及其用于治疗与同类激素相关的疾病和病症的施用方法。
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公开(公告)号：US20070065454A1
公开(公告)日：2007-03-22
申请号：US11489775
申请日：2006-07-20
CPC分类号： A61K38/24 , A61K9/127 , A61K38/09 , A61K38/2207 , A61K38/27 , A61K39/0005 , A61K2039/55555 , A61K2039/6031
摘要： The invention provides liposomal vehicles for encapsulating relatively high levels of water-soluble substances including immunogens directed against gastrin and gonadotropin releasing hormone. The liposome encapsulating large amounts of immunogens can be injected parentally to induce effective immune responses without exhibiting significant adverse tissue reactogenicity.
摘要翻译： 本发明提供用于包封相对高水平的水溶性物质的脂质体载体，包括针对胃泌素和促性腺激素释放激素的免疫原。 包封大量免疫原的脂质体可以亲本注射以诱导有效的免疫应答，而不显示显着的不利组织反应原性。
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公开(公告)号：US20070082043A1
公开(公告)日：2007-04-12
申请号：US11492695
申请日：2006-07-25
CPC分类号： A61K9/127 , A61K38/09 , A61K38/2207 , A61K38/24 , A61K38/27 , A61K39/0005 , A61K2039/55555 , A61K2039/6031
摘要： The invention provides liposomal vehicles for encapsulating relatively high levels of water-soluble substances including immunogens directed against gastrin and gonadotropin releasing hormone. The liposome encapsulating large amounts of immunogens can be injected parentally to induce effective immune responses without exhibiting significant adverse tissue reactogenicity.
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公开(公告)号：US10085940B2
公开(公告)日：2018-10-02
申请号：US14232332
申请日：2012-07-12
申请人： Alberto A. Gabizon , Yechezkel Barenholz , Hilary Shmeeda , John Maher , Ana Catarina Parente Pereira
发明人： Alberto A. Gabizon , Yechezkel Barenholz , Hilary Shmeeda , John Maher , Ana Catarina Parente Pereira
IPC分类号： A61K31/704 , A61K9/127 , A61K31/663 , A61K38/20 , A61K45/06 , A61K35/15 , A61K35/17 , A61K47/55 , A61K47/69 , A61K39/00
摘要： The present disclosure provides liposomes comprising a membrane and an intraliposomal aqueous water phase, the membrane comprising at least one liposome forming lipid and the intraliposomal aqueous water phase comprises a salt of a bisphosphonate together with an amphipathic weak base agent (PLAD). An example of a liposome is one comprising co encapsulated in the intraliposomal aqueous water phase N-containing bisphosphonate, such as alendronate, and an anthracycline such as doxorubicin which was shown to increase survival as compared to Doxil or to administrations of liposomal alendronate (PLA) and Doxil (separate liposomes). Such liposomes may carry a targeting moiety exposed at the liposome's outer surface, for example, conjugate of folic acid as a targeting moiety to folate receptor (FT-PLAD). Also provided by the present disclosure is a method of preparing the liposomes and methods of use of the liposomes, at times, in combination with additional active ingredients, such as γδ T-cells.
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公开(公告)号：US07985417B2
公开(公告)日：2011-07-26
申请号：US11246340
申请日：2005-10-07
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , A61K9/1277 , A61K47/6907 , A61K47/6913 , C07K16/32 , C07K2317/622
摘要： A method of inserting a lipid-linked moiety into a lipid assembly, such as a planar lipid monolayer or bilayer, a spherical lipid vesicle, a micelle, or an emulsion envelope monolayer is described. In the method, the lipid assembly and the lipid-linked moiety are contacted in the presence of microwave irradiation to permit the lipid-linked moiety to become associated with the lipid assembly. In one embodiment, the lipid assembly is a liposome and the lipid-linked moiety is a lipid-polymer. Compositions comprised of a lipid layer and of a lipid-linked moiety, prepared in accord with the method, are also described.
摘要翻译： 描述了将脂质连接的部分插入脂质组合物，例如平面脂质单层或双层，球形脂质囊泡，胶束或乳剂包膜单层中的方法。 在该方法中，脂质组装和脂质连接部分在微波照射的存在下接触以允许脂质连接部分与脂质组装相关联。 在一个实施方案中，脂质组合物是脂质体，脂质连接部分是脂质聚合物。 还描述了根据该方法制备的由脂质层和脂质连接部分组成的组合物。
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公开(公告)号：US20070087047A1
公开(公告)日：2007-04-19
申请号：US11633129
申请日：2006-12-01
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/00 , A61K38/12 , A61K38/1774 , A61K47/61 , A61K47/62 , A61K47/6911 , Y10S424/812 , A61K2300/00
摘要： A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
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公开(公告)号：US20050090478A1
公开(公告)日：2005-04-28
申请号：US10487154
申请日：2002-08-21
IPC分类号： C07D295/02 , A61K9/127 , A61K31/555 , A61P35/00 , A61P43/00 , C07D211/46 , C07D211/58 , C07F15/00
CPC分类号： C07F15/0093
摘要： The present invention concerns novel platinum complexes in which at least one of the amine ligand is a non-planar heterocyclic aliphatic amine. The platinum complexes may be in a trans or cis configuration and were found to posses therapeutic activites. Thus, the present concerns novel platinum complexes, pharmaceutical compositions comprising them and other uses thereof.
摘要翻译： 本发明涉及其中至少一种胺配体是非平面杂环脂族胺的新型铂络合物。 铂络合物可以是反式或顺式构型，并被发现具有治疗活性。 因此，本发明涉及新颖的铂络合物，包含它们的药物组合物和其它用途。
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公开(公告)号：US06696080B1
公开(公告)日：2004-02-24
申请号：US09711991
申请日：2000-11-13
IPC分类号： A61K9127
CPC分类号： A61K9/127 , A61K31/445
摘要： Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
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公开(公告)号：US06586002B2
公开(公告)日：2003-07-01
申请号：US09877978
申请日：2001-06-08
IPC分类号： A61K9127
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/00 , A61K38/12 , A61K38/1774 , A61K47/61 , A61K47/62 , A61K47/6911 , Y10S424/812 , A61K2300/00
摘要： A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
摘要翻译： 公开了包含小的表面结合效应分子的脂质体组合物。 脂质体具有亲水性聚合物链的表面层，用于增强血流中的循环时间。 效应分子连接到聚合物链的末端。 在一个实施方案中，效应物是多粘菌素B，用于治疗败血性休克。
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公开(公告)号：US6165501A
公开(公告)日：2000-12-26
申请号：US167403
申请日：1998-10-06
IPC分类号： A61K8/14 , A61K9/127 , A61Q17/04 , C07F9/10 , C08G65/335
CPC分类号： C08G65/3353 , A61K8/14 , A61K9/1272 , A61Q17/04 , C07F9/10
摘要： Ether-linked phospholipids, derivatized at the polar head group with polyethylene glycol chains having molecular weights greater than 2,000 daltons, are disclosed. Lipid bilayers containing these phospholipids show high oxidative stability. Also disclosed is the use of PEG-derivatized ether-linked lipids in moisturizing and radiation-protective cosmetic compositions.
摘要翻译： 公开了在极性头基衍生的分子量大于2,000道尔顿的聚乙二醇链的醚连接的磷脂。 含有这些磷脂的脂质双层显示出高的氧化稳定性。 还公开了在保湿和辐射保护的化妆品组合物中使用PEG衍生的醚连接的脂质。
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