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公开(公告)号：US20190142866A1
公开(公告)日：2019-05-16
申请号：US15811007
申请日：2017-11-13
Applicant: Carol Angela Howell , Sergey Victorovich Mikhalovsky , Susan Rachel Sandeman , Rajiv Jalan , Jane MacNaughtan
Inventor： Carol Angela Howell , Sergey Victorovich Mikhalovsky , Susan Rachel Sandeman , Rajiv Jalan , Jane MacNaughtan
Abstract: The invention provides porous carbon particles for use in the treatment or prevention of liver disease, wherein at least 20% of the total pore volume is made up of pores having a mean diameter of from 2 to 200 nm and/or wherein the particles comprise micropores of diameter 2 nm or less and small macropores of diameter 50 nm to 500 nm, but substantially no mesopores of diameter greater than 2 nm and less than 50 nm, and substantially no large macropores of diameter greater than 500 nm.
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公开(公告)号：US20130072845A1
公开(公告)日：2013-03-21
申请号：US13513340
申请日：2010-12-09
Applicant: Stephen Robert Tennison , Oleksandr Prokopovyeh Kozynchenko , Anthony Paul Rawlinson , Gary James Phillips , Carol Angela Howell , Susan Rachel Sandeman , Sergey Victorovich Mikhalovsky
Inventor： Stephen Robert Tennison , Oleksandr Prokopovyeh Kozynchenko , Anthony Paul Rawlinson , Gary James Phillips , Carol Angela Howell , Susan Rachel Sandeman , Sergey Victorovich Mikhalovsky
IPC: A61M1/34
CPC classification number: A61M1/34 , A61M1/3486 , A61M1/3496 , A61M1/362 , A61M2202/0057 , A61M2202/0407 , A61M2202/07 , A61M2202/08 , A61M2202/203
Abstract: Whole blood is treated extracorporeally to remove substances contrary to health using mesoporous/microporous or macroporopus/microporous carbon in the form of beads or a channel monolith. The carbon may be the result of carbonising a mesoporous or macroporous phenolic resin. Substances contrary to health include externally introduced toxins such as bacterially derived staphylococcus enterotoxins A, B, TSST-1 or autologous, biologically active molecules with harmful, systemic effects when their activity is excessive or unregulated. Examples include the removal of inappropriate amounts of pro- or anti-inflammatory molecules and toxic mediators of systemic inflammatory response syndrome related to sepsis, cardio-pulmonary by-pass surgery, ischaemic reperfusioninjury; the removal of larger molecular weight and protein bound uremic toxins related to kidney and hepatic toxins related to liver failure and the removal of toxins relevant to biological and chemical warfare.
Abstract translation: 使用球形或通道整体形式的介孔/微孔或大孔/微孔碳体外处理全血以除去与健康相反的物质。 碳可能是中孔或大孔酚醛树脂碳化的结果。 与健康相反的物质包括外来引入的毒素，如细菌衍生的葡萄球菌肠毒素A，B，TSST-1或自身的生物活性分子，当其活性过度或不受调节时，具有有害的全身作用。 实例包括去除与脓毒症，心肺旁路手术，缺血性再灌注损伤有关的全身炎症反应综合征的不利量的促炎或抗炎分子和毒性介质; 去除与肝衰竭有关的肾脏和肝脏毒素相关的较大分子量和蛋白质结合的尿毒症毒素以及与生物和化学战争相关的毒素的去除。
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公开(公告)号：US09278170B2
公开(公告)日：2016-03-08
申请号：US13513340
申请日：2010-12-09
Applicant: Stephen Robert Tennison , Oleksandr Prokopovyeh Kozynchenko , Anthony Paul Rawlinson , Gary James Phillips , Carol Angela Howell , Susan Rachel Sandeman , Sergey Victorovich Mikhalovsky
Inventor： Stephen Robert Tennison , Oleksandr Prokopovyeh Kozynchenko , Anthony Paul Rawlinson , Gary James Phillips , Carol Angela Howell , Susan Rachel Sandeman , Sergey Victorovich Mikhalovsky
CPC classification number: A61M1/34 , A61M1/3486 , A61M1/3496 , A61M1/362 , A61M2202/0057 , A61M2202/0407 , A61M2202/07 , A61M2202/08 , A61M2202/203
Abstract: Whole blood is treated extracorporeally to remove substances contrary to health using mesoporous/microporous or macroporopus/microporous carbon in the form of beads or a channel monolith. The carbon may be the result of carbonizing a mesoporous or macroporous phenolic resin. Substances contrary to health include externally introduced toxins such as bacterially derived staphylococcus enterotoxins A, B, TSST-1 or autologous, biologically active molecules with harmful, systemic effects when their activity is excessive or unregulated. Examples include the removal of inappropriate amounts of pro- or anti-inflammatory molecules and toxic mediators of systemic inflammatory response syndrome related to sepsis, cardio-pulmonary by-pass surgery, ischaemic reperfusion injury; the removal of larger molecular weight and protein bound uremic toxins related to kidney and hepatic toxins related to liver failure and the removal of toxins relevant to biological and chemical warfare.
Abstract translation: 使用球形或通道整体形式的介孔/微孔或大孔/微孔碳体外处理全血以除去与健康相反的物质。 碳可以是中孔或大孔酚醛树脂碳化的结果。 与健康相反的物质包括外来引入的毒素，如细菌衍生的葡萄球菌肠毒素A，B，TSST-1或自身的生物活性分子，当其活性过度或不受调节时，具有有害的全身作用。 实例包括去除与脓毒症，心肺旁路手术，缺血再灌注损伤相关的全身炎症反应综合征的不利量的促炎或抗炎分子和毒性介质; 去除与肝衰竭有关的肾脏和肝脏毒素相关的较大分子量和蛋白质结合的尿毒症毒素以及与生物和化学战争相关的毒素的去除。
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