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1.发明申请USE OF CATECHOLAMINES AND RELATED COMPOUNDS AS ANTI-ANGIOGENIC AGENTS 有权使用CATECHOLAMINES和相关化合物作为抗生素公开(公告)号：US20100069401A1
公开(公告)日：2010-03-18
申请号：US12448981
申请日：2008-01-29
IPC分类号： A61K31/137 , A61P9/00 , A61K31/445 , A61K31/522 , A61K31/4965
CPC分类号： A61K31/137 , A61K9/0048 , A61K31/216 , A61K31/222 , A61K31/36 , A61K31/445 , A61K31/495 , A61K31/522
摘要： A catecholamine or related compound of formula (I) having (S)-configuration at β-carbon and having a lipophilicity greater than (S)-noradrenalme, a physiologically tolerated salt thereof, a prodrug thereof, a physiologically functional derivative thereof or any mixture thereof is useful as an anti-angiogemc agent A catecholamine or related compound of formula (II) in which a β-hydroxy group has been modified is also anti-angiogemc
摘要翻译： 具有（S） - 构型并具有大于（S） - 肾上腺素的亲脂性的儿茶酚胺或其相关化合物，其生理学耐受的盐，其前药，其生理功能衍生物或任何 其混合物可用作抗血管生成剂A.已经修饰了＆bgr-羟基的儿茶酚胺或式（II）的相关化合物也是抗血管生成素
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2.发明授权公开(公告)号：US09351947B2
公开(公告)日：2016-05-31
申请号：US12448981
申请日：2008-01-29
IPC分类号： A61K31/137 , A61K31/216 , A61K31/222 , A61K31/36 , A61K31/445 , A61K31/495 , A61K31/522
CPC分类号： A61K31/137 , A61K9/0048 , A61K31/216 , A61K31/222 , A61K31/36 , A61K31/445 , A61K31/495 , A61K31/522
摘要： A catecholamine or related compound having (S)-configuration at β-carbon, a physiologically tolerated salt thereof, a prodrug thereof, a physiologically functional derivative thereof or any mixture thereof and having a lipophilicity greater than (S)-noradrenaline has use as an anti-angiogenic agent. A catecholamine or related compound in which a β-hydroxy group has been modified are also anti-angiogenic. The anti-angiogenic agent is preferably a compound of formula (I) or (II) a physiologically tolerated salt thereof, a prodrug thereof, a physiologically functional derivative thereof or any mixture thereof.
摘要翻译： 具有（S）构型的碳原子数为1〜8的碳原子数为1〜4的烷氧基苯基或其相应的化合物，其生理学上可接受的盐，其前体药物，其生理功能衍生物或其任何混合物的亲油性大于（S） - 非 - 抗血管生成剂。 已经修饰了＆bgr-羟基的儿茶酚胺或相关化合物也是抗血管生成的。 抗血管生成剂优选为式（I）或（II）的化合物，其生理学上耐受的盐，其前药，其生理功能衍生物或其任何混合物。
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