公开(公告)号：US20120328708A1

公开(公告)日：2012-12-27

申请号：US13579577

申请日：2011-02-18

申请人： Suzette Veronica Van Der Waal ,  Stanley Brul ,  Johannes Jacob De Soet ,  Lucas Wilhelmus Maria Van Der Sluis

发明人： Suzette Veronica Van Der Waal ,  Stanley Brul ,  Johannes Jacob De Soet ,  Lucas Wilhelmus Maria Van Der Sluis

IPC分类号： A61K31/19 ,  C07C57/10 ,  A61P31/00 ,  C07C53/06 ,  A61K33/00 ,  C07C53/10 ,  C07C59/08

CPC分类号： A61K9/006 ,  A61K6/0035 ,  A61K47/12 ,  A61K47/26

摘要： The present invention concerns a disinfectant or antimicrobial composition for use in dental treatment, such as treatment and/or prevention of periodontitis, gingivitis or other forms of oral infection. The present Inventor found that microorganisms that infect the dental tissues and cause inflammation thereof, are susceptible to osmotic stress, to such extent that the application of a hypertonic composition is effective in curing or preventing infection and/or inflammations. It was furthermore found that these microorganisms are also susceptible to acidic stress. The present invention therefore provides compositions that induce osmotic stress in microorganisms causing infection of dental tissue when topically applied thereto, preferably osmotic as well as acidic stress. The present invention also concerns the methods and uses involving the compositions of the invention.

摘要翻译： 本发明涉及用于牙科治疗的消毒剂或抗微生物组合物，例如治疗和/或预防牙周炎，牙龈炎或其它形式的口腔感染。 本发明人发现感染牙科组织并引起其炎症的微生物易渗透压力，使得高渗组合物的施用有效地治愈或预防感染和/或炎症。 此外，还发现这些微生物也易受酸性胁迫。 因此，本发明提供了当在局部施用于其上时诱导牙科组织感染的微生物诱导渗透胁迫的组合物，优选渗透性和酸性应激。 本发明还涉及涉及本发明组合物的方法和用途。

公开(公告)号：US08808718B2

公开(公告)日：2014-08-19

申请号：US13579577

申请日：2011-02-18

申请人： Suzette Veronica Van Der Waal ,  Stanley Brul ,  Johannes Jacob De Soet ,  Lucas Wilhelmus Maria Van Der Sluis

发明人： Suzette Veronica Van Der Waal ,  Stanley Brul ,  Johannes Jacob De Soet ,  Lucas Wilhelmus Maria Van Der Sluis

IPC分类号： A61K8/02 ,  A61K47/26 ,  A61K9/00 ,  A61K6/00 ,  A61K47/12

CPC分类号： A61K9/006 ,  A61K6/0035 ,  A61K47/12 ,  A61K47/26

摘要： The present invention concerns a disinfectant or antimicrobial composition for use in dental treatment, such as treatment and/or prevention of periodontitis, gingivitis or other forms of oral infection. The present Inventor found that microorganisms that infect the dental tissues and cause inflammation thereof, are susceptible to osmotic stress, to such extent that the application of a hypertonic composition is effective in curing or preventing infection and/or inflammations. It was furthermore found that these microorganisms are also susceptible to acidic stress. The present invention therefore provides compositions that induce osmotic stress in microorganisms causing infection of dental tissue when topically applied thereto, preferably osmotic as well as acidic stress. The present invention also concerns the methods and uses involving the compositions of the invention.

摘要翻译： 本发明涉及用于牙科治疗的消毒剂或抗微生物组合物，例如治疗和/或预防牙周炎，牙龈炎或其它形式的口腔感染。 本发明人发现感染牙科组织并引起其炎症的微生物易渗透压力，使得高渗组合物的施用有效地治愈或预防感染和/或炎症。 此外，还发现这些微生物也易受酸性胁迫。 因此，本发明提供了当在局部施用于其上时诱导牙科组织感染的微生物诱导渗透胁迫的组合物，优选渗透性和酸性应激。 本发明还涉及涉及本发明组合物的方法和用途。