公开(公告)号：US20120328708A1

公开(公告)日：2012-12-27

申请号：US13579577

申请日：2011-02-18

申请人： Suzette Veronica Van Der Waal ,  Stanley Brul ,  Johannes Jacob De Soet ,  Lucas Wilhelmus Maria Van Der Sluis

发明人： Suzette Veronica Van Der Waal ,  Stanley Brul ,  Johannes Jacob De Soet ,  Lucas Wilhelmus Maria Van Der Sluis

IPC分类号： A61K31/19 ,  C07C57/10 ,  A61P31/00 ,  C07C53/06 ,  A61K33/00 ,  C07C53/10 ,  C07C59/08

CPC分类号： A61K9/006 ,  A61K6/0035 ,  A61K47/12 ,  A61K47/26

摘要： The present invention concerns a disinfectant or antimicrobial composition for use in dental treatment, such as treatment and/or prevention of periodontitis, gingivitis or other forms of oral infection. The present Inventor found that microorganisms that infect the dental tissues and cause inflammation thereof, are susceptible to osmotic stress, to such extent that the application of a hypertonic composition is effective in curing or preventing infection and/or inflammations. It was furthermore found that these microorganisms are also susceptible to acidic stress. The present invention therefore provides compositions that induce osmotic stress in microorganisms causing infection of dental tissue when topically applied thereto, preferably osmotic as well as acidic stress. The present invention also concerns the methods and uses involving the compositions of the invention.

摘要翻译： 本发明涉及用于牙科治疗的消毒剂或抗微生物组合物，例如治疗和/或预防牙周炎，牙龈炎或其它形式的口腔感染。 本发明人发现感染牙科组织并引起其炎症的微生物易渗透压力，使得高渗组合物的施用有效地治愈或预防感染和/或炎症。 此外，还发现这些微生物也易受酸性胁迫。 因此，本发明提供了当在局部施用于其上时诱导牙科组织感染的微生物诱导渗透胁迫的组合物，优选渗透性和酸性应激。 本发明还涉及涉及本发明组合物的方法和用途。

公开(公告)号：US20090035288A1

公开(公告)日：2009-02-05

申请号：US11989059

申请日：2006-06-29

申请人： Ruud Albers ,  Stanley Brul ,  Adrianus Marinus Ledeboer ,  Willem Maarten Meijer

发明人： Ruud Albers ,  Stanley Brul ,  Adrianus Marinus Ledeboer ,  Willem Maarten Meijer

IPC分类号： A61K35/74

CPC分类号： A23C9/12 ,  A23G9/00 ,  A23G2200/02

摘要： The present invention provides a method of preparing an edible product comprising non-viable bacteria providing a health benefit, the method comprising subjecting viable bacteria to at least two sub-lethal treatments to obtain the non-viable bacteria providing a health benefit, each sub-lethal treatment on its own not being sufficient to render the bacteria non-viable. The method porvides non-viable bacteria providing health benefits but which can conveniently be incorporated into a range of edible products.

摘要翻译： 本发明提供一种制备包含提供健康益处的非活细菌的食用产品的方法，所述方法包括将活细菌经受至少两次次致死处理以获得提供健康益处的非存活细菌， 致命的治疗本身不足以使细菌不可行。 该方法培养提供健康益处的非活细菌，但可方便地并入一系列可食用产品中。

公开(公告)号：US06280725B1

公开(公告)日：2001-08-28

申请号：US09484748

申请日：2000-01-18

申请人： Isaac Bom ,  Stanley Brul

发明人： Isaac Bom ,  Stanley Brul

IPC分类号： A61K3843

CPC分类号： A23L3/3562 ,  A01N43/16 ,  A23L3/34635 ,  A23L3/3472 ,  A23L3/349 ,  A23L3/3508 ,  A23L3/3526 ,  A01N63/02 ,  A01N61/00 ,  A01N43/90 ,  A01N37/46 ,  A01N37/06 ,  A01N31/08 ,  A01N2300/00

摘要： A composition suitable for inhibiting the outgrowth of fungi is provided comprising a first ingredient which inhibits the biogenesis of a normal fungal cell wall and a second ingredient which is capable of perturbing the structure of the cellular membrane of said fungi, so that either the cellular integrity is essentially lost or cell division cannot take place, or both. The first ingredient preferably inhibits the anchorage of cell wall proteins in the cell wall of the fungi and is suitably a &bgr;-(1,6)-glucose polysaccharide, preferably &bgr;-gentiobiose or a pustulan fragment. The second ingredient is suitably a natural microbial membrane affecting substance (MMAS), preferably MB-21. The composition is particularly suitable as a preservative for inhibiting the outgrowth of fungi in food products, such as sauces, dressings, ketchups, and soups, but is also useful for preventing or inhibiting undesired fungal growth on other products such as personal health care products, e.g. soap bars.

摘要翻译： 提供了适合抑制真菌生长的组合物，其包含抑制正常真菌细胞壁的生物发生的第一成分和能够扰乱所述真菌细胞膜结构的第二成分，使得细胞完整性 基本上丢失或细胞分裂不能发生，或两者兼而有之。 第一成分优选抑制真菌细胞壁中细胞壁蛋白质的锚定，并且适宜地是β-（1,6） - 葡萄糖多糖，优选β-龙胆糖或脓疱疮片段。 第二种成分适宜是天然的微生物膜影响物质（MMAS），最好是MB-21。 该组合物特别适合作为防止食品中调味汁，酱料，番茄酱，汤等真菌生长的防腐剂，但也可用于预防或抑制其他产品如个人保健品， 例如 肥皂条。

公开(公告)号：US20090123608A1

公开(公告)日：2009-05-14

申请号：US11989062

申请日：2006-06-27

申请人： Ruud Albers ,  Adrianus Marinus Ledeboer ,  Stanley Brul

发明人： Ruud Albers ,  Adrianus Marinus Ledeboer ,  Stanley Brul

IPC分类号： A23L1/30 ,  A23L1/28

CPC分类号： A23G9/00 ,  A23C9/12 ,  A23G2200/02

摘要： The present invention provides a method of preparing an edible product comprising non-viable moulds and/or yeasts that are substantially structurally intact and which provide a health benefit, the method comprising subjecting viable moulds and/or yeasts to at least two sub-lethal treatments to obtain the non-viable moulds and/or yeasts providing a health benefit, each sub-lethal treatment on its own not being sufficient to render the moulds and/or yeasts non-viable.

摘要翻译： 本发明提供了一种制备可食用产品的方法，所述食用产品包含基本上在结构上完整无损并且提供健康益处的非存活霉菌和/或酵母，所述方法包括将存活霉菌和/或酵母经受至少两种次致死处理 为了获得提供健康益处的不可行的霉菌和/或酵母，其本身的每种亚致死治疗不足以使霉菌和/或酵母不能存活。

公开(公告)号：US08808718B2

公开(公告)日：2014-08-19

申请号：US13579577

申请日：2011-02-18

申请人： Suzette Veronica Van Der Waal ,  Stanley Brul ,  Johannes Jacob De Soet ,  Lucas Wilhelmus Maria Van Der Sluis

发明人： Suzette Veronica Van Der Waal ,  Stanley Brul ,  Johannes Jacob De Soet ,  Lucas Wilhelmus Maria Van Der Sluis

IPC分类号： A61K8/02 ,  A61K47/26 ,  A61K9/00 ,  A61K6/00 ,  A61K47/12

CPC分类号： A61K9/006 ,  A61K6/0035 ,  A61K47/12 ,  A61K47/26

摘要： The present invention concerns a disinfectant or antimicrobial composition for use in dental treatment, such as treatment and/or prevention of periodontitis, gingivitis or other forms of oral infection. The present Inventor found that microorganisms that infect the dental tissues and cause inflammation thereof, are susceptible to osmotic stress, to such extent that the application of a hypertonic composition is effective in curing or preventing infection and/or inflammations. It was furthermore found that these microorganisms are also susceptible to acidic stress. The present invention therefore provides compositions that induce osmotic stress in microorganisms causing infection of dental tissue when topically applied thereto, preferably osmotic as well as acidic stress. The present invention also concerns the methods and uses involving the compositions of the invention.

摘要翻译： 本发明涉及用于牙科治疗的消毒剂或抗微生物组合物，例如治疗和/或预防牙周炎，牙龈炎或其它形式的口腔感染。 本发明人发现感染牙科组织并引起其炎症的微生物易渗透压力，使得高渗组合物的施用有效地治愈或预防感染和/或炎症。 此外，还发现这些微生物也易受酸性胁迫。 因此，本发明提供了当在局部施用于其上时诱导牙科组织感染的微生物诱导渗透胁迫的组合物，优选渗透性和酸性应激。 本发明还涉及涉及本发明组合物的方法和用途。

公开(公告)号：US5888504A

公开(公告)日：1999-03-30

申请号：US742730

申请日：1996-11-01

申请人： Stanley Brul ,  Peter Coote ,  Shanti Dielbanhoesing ,  Suzanna Oomes ,  Wilma M. Stam ,  Geke Naaktgeboren-Stoffels ,  Malcolm Stratford

发明人： Stanley Brul ,  Peter Coote ,  Shanti Dielbanhoesing ,  Suzanna Oomes ,  Wilma M. Stam ,  Geke Naaktgeboren-Stoffels ,  Malcolm Stratford

IPC分类号： A01N63/00 ,  A23L3/3463 ,  A23L3/3526 ,  A23L3/3571 ,  A61K8/64 ,  A61K8/66 ,  A61P31/10 ,  A61Q5/02 ,  A61Q17/00 ,  A61K38/43 ,  A61K38/47 ,  A61K38/54

CPC分类号： A61K8/66 ,  A01N63/00 ,  A23L3/34635 ,  A23L3/3571 ,  A61K8/64 ,  A61Q17/005 ,  A61Q5/02

摘要： Composition suitable for combatting fungi characterized in that it comprises at least one fungi cell wall lytic enzyme and a natural microbial cell membrane affecting substance in an effective concentration. Preferably the composition is a food product.

摘要翻译： 其特征在于它包含至少一种真菌细胞壁溶解酶和有效浓度影响物质的天然微生物细胞膜。 优选地，组合物是食品。