公开(公告)号：US20170029443A1

公开(公告)日：2017-02-02

申请号：US15293511

申请日：2016-10-14

申请人： AMGEN, INC.

发明人： David BAUER ,  Matthew BIO ,  Melanie COOKE ,  Katrina W. COPELAND ,  Matthew PETERSON ,  Michele POTASHMAN ,  Roman SHIMANOVICH ,  Helming TAN

IPC分类号： C07D519/00 ,  C07C275/02 ,  C07C57/10 ,  C07C55/12 ,  C07C57/145 ,  C07C55/10

CPC分类号： C07D519/00 ,  A61K31/52 ,  C07B2200/13 ,  C07C55/10 ,  C07C55/12 ,  C07C57/10 ,  C07C57/145 ,  C07C275/02

摘要： Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the invention provides polymorphs and co-crystals of 6-{(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, which is an inhibitor of c-Met.

摘要翻译： 本文提供了可用于治疗，预防或改善癌症的化合物的新型多晶型物和共晶体。 特别地，本发明提供了6 - {（1R）-1- [8-氟-6-（1-甲基-1H-吡唑-4-基）[1,2,4]三唑并[ 4,3-a]吡啶-3-基]乙基} -3-（2-甲氧基乙氧基）-1,6-萘啶-5（6H） - 酮，其是c-Met的抑制剂。

公开(公告)号：US4207350A

公开(公告)日：1980-06-10

申请号：US848665

申请日：1977-11-04

申请人： Ryuzo Ueno ,  Toshio Matsuda ,  Shigeo Inamine

发明人： Ryuzo Ueno ,  Toshio Matsuda ,  Shigeo Inamine

IPC分类号： A23L3/34 ,  A23C19/082 ,  A23C19/10 ,  A23K1/16 ,  A23K3/00 ,  A23L1/00 ,  A23L3/3508 ,  C07C51/00 ,  C07C51/50 ,  C07C57/10 ,  C07C67/00 ,  A23C19/12

CPC分类号： A23C19/082 ,  A23C19/10 ,  A23K30/00 ,  A23L3/3508 ,  A23P10/47

摘要： A process for preserving process cheese which comprises admixing with natural cheese during the steps of preparing process cheese from natural cheese sorbic acid-containing powder or granules having particle diameter of 300 microns or more comprising 5-90% by weight of finely divided sorbic acid and 10-95% by weight of an easily water-soluble substance which is a solid at normal temperature.

摘要翻译： 一种保存加工干酪的方法，其包括在由具有300微米或更大粒度的天然干酪含山梨酸的粉末或颗粒制备加工干酪的步骤中与天然干酪混合，其包含5-90重量％的细碎山梨酸和 10-95重量％的常温下为固体的易溶于水的物质。

公开(公告)号：US3586714A

公开(公告)日：1971-06-22

申请号：US3586714D

申请日：1968-06-10

申请人： MONTEDISON SPA

发明人： DUBINI MARIO ,  FERRARIS MARIO ,  MERZONI SERGIO ,  CHIUSOLI GIAN PAOLO

IPC分类号： C07C51/09 ,  C07C51/353 ,  C07C57/10

CPC分类号： C07C51/09 ,  C07C51/353 ,  C07C57/10

摘要： DESCRIBED IS A PROCESS FOR PREPARING 2-TRANS-4-TRANS SORBIC ACID FROM PURE METHYL 2-CIS-5,2-TRANS-5,3-TRANS-5, HEXADIENOATE OR FORM MIXTURES THEREOF. THE PROCESS IS CHARACTERIZED BY THE FOLLOWING STEPS: METHYL HEXADIENOATE IS DISSOLVED IN METHANOL, USING 0.5 TO 1 PART OF METHANOL PER 1 PART OF ESTER; SOLID SODIUM HYDROXIDE IS ADDED IN AMOUNT FROM 0.5 TO 3% BY WEIGHT IN RESPECT OF THE ESTER AND THE WHOLE IS AGITATED AT 20-40*C. FOR 60-120 MINUTES (STEP A); SODIUM HYDROXIDE IS ADDED IN STOICHIOMETRIC AMOUNT FOR THE SAPONIFICATION AND THE WHOLE IS HEATED TO 60-80*C. FOR 60-120 MINUTES UNDER STIRRING (STEP B); WATER IS ADDED IN AMOUNT FROM 0.5 TO 1.5 VOLUMES OF WATER PER VOLUME OF SOLUTION IN ORDER TO DISSOLVE THE SALTS, AND THE METHANOL IS DISTILLED (STEP C); THE SOLUTION IS ACIDIFIED TO PH OF 3.5 WITH 5-15% SULFURIC ACID (STEP D); AFTER FILTRATION AT BETWEEN 30 AND 40*C. (STEP E), THE FILTER CAKE IS WASHED WITH WATER AND WITH AQUEOUS METHANOL (STEP F) THUS OBTAINING 2-TRANS-4-TRANS SORBIC ACID, WITH A PURITY HIGHER THAN 99%.

公开(公告)号：US20210061783A1

公开(公告)日：2021-03-04

申请号：US16734413

申请日：2020-01-06

申请人： Yunnan Xike Science & Technology Co., Ltd.

发明人： Zheng Chen ,  Yinghui Cao ,  Ningning Yan ,  Songfeng Wang ,  Yong Zhang ,  Yuefeng Chen ,  Zhennan Huang ,  Shenghong Yuan

IPC分类号： C07D401/04 ,  C07D207/04 ,  C07D241/04 ,  C07D233/58 ,  C07D235/06 ,  C07C25/08 ,  C07C233/07 ,  C07C53/02 ,  C07C53/08 ,  C07C59/265 ,  C07C59/08 ,  C07C53/126 ,  C07C57/10 ,  C07C57/12 ,  C07C63/06 ,  C07C59/185 ,  C07C237/22

摘要： A synthetic nicotine composition comprising synthetic nicotine, a synthetic nicotine salt and a synthetic nicotine derivative, wherein the synthetic nicotine, the synthetic nicotine salt, and the synthetic nicotine derivative are in mass percentage; the synthetic nicotine accounts for 1-20%, the synthetic nicotine salt accounts for 30-70%, and the synthetic nicotine derivative accounts for 20-50%; and the synthetic nicotine is one or more of S-nicotine and a mixture of R-nicotine containing a racemate and S-nicotine. The synthetic nicotine, synthetic nicotine salt and synthetic nicotine derivative according to the present invention are proportionally mixed to prepare an existing synthetic nicotine product, which relieves the problem of the impact of impurities in natural extracted nicotine products causing an unpleasant smell, a bitter taste and a strong volatility, and can be used in the fields of low temperature heat-not-burn products, snuff, electronic cigarettes, nicotine release patches, insecticides, herbicides, microbicides, drug synthesis, etc.

公开(公告)号：US10815184B2

公开(公告)日：2020-10-27

申请号：US16309370

申请日：2017-06-13

申请人： SyneuRx International (Taiwan) Corp.

发明人： Guochuan Emil Tsai ,  Ching-Cheng Wang ,  Tien-Lan Hsieh ,  Yuan-Chun Lo

IPC分类号： A61K33/14 ,  C07C63/08 ,  A61P35/00 ,  C07C215/54 ,  C07D213/80 ,  A61P25/28 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  C07C57/10

摘要： The present disclosure provides co-crystals of a lithium benzoate compound and a co-former compound of Formula (I) Also provided herein are methods of preparing the co-crystals and uses thereof in treating and/or reducing the risk for a neuropsychiatric disorder (e.g., schizophrenia, psychotic disorders, depressive disorders, bipolar disorders, or neurodegenerative disorders).

公开(公告)号：US10016734B2

公开(公告)日：2018-07-10

申请号：US15263354

申请日：2016-09-12

申请人： NINGBO WANGLONG TECH CO.,LTD

发明人： Handong Wang ,  Gongnian Xiao ,  Guojun Wang ,  Lijun Chen ,  Anna Lu ,  Yuanzhe Chen ,  Conghui Huang

IPC分类号： C07C57/10 ,  B01J2/02 ,  B01J2/16 ,  B01J2/18

CPC分类号： B01J2/16 ,  C07C45/89 ,  C07C51/09 ,  C07C51/412 ,  C07C51/43 ,  C07C51/50 ,  C07C57/10 ,  C07C49/90

摘要： The present invention discloses a method of producing potassium sorbate particles, comprising the steps of: (1) preparing a potassium sorbate solution; (2) spray drying; (3) spray forming; (4) indirectly drying with steam on a vibration fluidized bed; and (5) swing-type sifting; in step (3), a binder is obtained by spray drying after adding sorbitol to the potassium sorbate solution prepared in step (1), and the binder is mixed with the potassium sorbate powder obtained by spray drying in step (2) to undergo the spray forming process; based on weight ratio, the weight ratio of the sorbitol required to prepare the binder to the potassium sorbate solution required to prepare the binder is 0.05-0.1%:1. The beneficial effects of the present invention are: an appropriate binding effect of the powder particles, a good breaking effect and a good spheronization effect of the powder particles, and uniformity of granulation.

公开(公告)号：US08404890B2

公开(公告)日：2013-03-26

申请号：US12943433

申请日：2010-11-10

申请人： James A. Dumesic ,  Mei Chia

发明人： James A. Dumesic ,  Mei Chia

IPC分类号： C07C57/10 ,  C07C45/60 ,  C07C5/48

CPC分类号： C07C1/213 ,  C07C51/09 ,  C07C2531/10 ,  C07C11/20 ,  C07C57/10

摘要： Described is a method of making sorbic acid, pentadiene, or 3-penten-2-one. The method includes partially hydrogenating 4-hydroxy-6-methyl-2-pyrone (HMP) to yield 5,6-dihydro-4-hydroxy-6-methyl-2H-pyran-2-one (4-DHMMP). Then, if 3-penten-2-one is desired, thermally decomposing the 4-DHMMP to yield 3-penten-2-one. If sorbic acid or pentadiene are desired, the 4-DHMMP is hydrogenated to yield 4-hydroxy-6-methyltetrahydro-2-pyrone (4-HMTHP). The 4-HMTHP is then dehydrated by contacting it with a solid acid catalyst to yield parasorbic acid (PSA). The PSA can then be ring-opened by contacting it with a solid acid catalyst. The reaction conditions of the ring-opening reaction can be controlled to yield sorbic acid and/or pentadiene.

摘要翻译： 描述了制备山梨酸，戊二烯或3-戊烯-2-酮的方法。 该方法包括部分氢化4-羟基-6-甲基-2-吡喃酮（HMP），得到5,6-二氢-4-羟基-6-甲基-2H-吡喃-2-酮（4-DHMMP）。 然后，如果需要3-戊烯-2-酮，则热分解4-DHMMP以得到3-戊烯-2-酮。 如果需要山梨酸或戊二烯，则将4-DHMMP氢化，得到4-羟基-6-甲基四氢-2-吡喃酮（4-HMTHP）。 然后通过使其与固体酸催化剂接触来脱水4-HMTHP以得到异烟酸（PSA）。 然后可以通过使其与固体酸催化剂接触来使PSA开环。 可以控制开环反应的反应条件以产生山梨酸和/或戊二烯。

公开(公告)号：US20080051453A1

公开(公告)日：2008-02-28

申请号：US11895071

申请日：2007-08-22

申请人： Annette Bak ,  Drazen Ostovic

发明人： Annette Bak ,  Drazen Ostovic

IPC分类号： A61K31/19 ,  C07C57/03 ,  C07C57/10

CPC分类号： A61K9/2004 ,  C07C57/03 ,  C07C57/10 ,  C07C57/13 ,  C30B7/00

摘要： The present invention relates to a pharmaceutical co-crystal comprising an active pharmaceutical ingredient and a co-crystal agent having the structure R1—C(═O)XH.

摘要翻译： 本发明涉及包含活性药物成分和具有结构R 1 -C（-O）XH的共结晶剂的药用共晶体。

公开(公告)号：US5200559A

公开(公告)日：1993-04-06

申请号：US760196

申请日：1991-09-16

申请人： Masahiro Nakajima

发明人： Masahiro Nakajima

IPC分类号： B01J31/08 ,  B01J31/10 ,  C07B61/00 ,  C07C51/09 ,  C07C57/10 ,  C08G63/00 ,  C08G63/88

CPC分类号： C08G63/88 ,  B01J31/10 ,  C07C51/09 ,  C08G63/005

摘要： A process for producing sorbic acid from a polyester obtained by reaction of crotonaldehyde with ketene using an organic acid zinc salt as catalyst is provided, which process comprises dissolving the polyester in an aromatic hydrocarbon solvent having an azeotropic temperature of the solvent with water of 92.degree. to 100.degree. C., followed by washing the polyester solution with water or a mineral acid water to remove zinc matter and continuously contacting the solution with a strongly acidic porous ion exchange resin, the process being simple, commercially profitable, making possible a long term operation of the polyester decomposition apparatus, capable of easily purifying sorbic acid and affording sorbic acid with a good yeild.

摘要翻译： 提供了一种通过使用有机酸锌盐作为催化剂使巴豆醛与乙烯酮反应获得的聚酯生产山梨酸的方法，该方法包括将聚酯溶解在溶剂的共沸温度为92℃的芳族烃溶剂中 至100℃，然后用水或无机酸水洗涤聚酯溶液以除去锌物质，并使该溶液与强酸性多孔离子交换树脂连续接触，该方法简单，商业上有利可图，使得长期可能 聚酯分解装置的操作，能够容易地纯化山梨酸并提供良好的山梨酸。

公开(公告)号：US4822913A

公开(公告)日：1989-04-18

申请号：US546410

申请日：1983-10-28

申请人： Gary P. Hagen

发明人： Gary P. Hagen

IPC分类号： C07C27/02 ,  C07C29/09 ,  C07C51/09 ,  C07C53/08 ,  C07C57/04 ,  C07C57/10 ,  C07C57/44

CPC分类号： C07C51/09 ,  C07C29/09

摘要： Esters of carboxylic acids of the formula RCH.sub.2 COOR"' and R'CH:C(R")COOR"' are reacted to form a carboxylic acid and an aliphatic alcohol R"'OH wherein R, R', and R" are individually selected from the group consisting of --H, alkyl moieties of from 1 to 18 carbon atoms and aralkyl moieties, cycloalkyl moieties and alkylaryl moieties of 3 to 18 carbon atoms and R"' is an alkyl moiety of 1 to 18 carbon atoms in the presence of an AMS-1B borosilicate crystalline molecular sieve catalyst under reaction conditions.

摘要翻译： 使式RCH 2 COOR“'和R'CH：C（R”）COOR“的羧酸酯反应形成羧酸和脂族醇R”OH，其中R，R'和R “分别选自-H，1至18个碳原子的烷基部分和3至18个碳原子的芳烷基部分，环烷基部分和烷基芳基部分，”R“是1至18的烷基部分 在AMS-1B硼硅酸盐结晶分子筛催化剂存在下，在反应条件下进行。