Functionalized Nanoceria Composition For Ophthalmic Treatment
    1.
    发明申请
    Functionalized Nanoceria Composition For Ophthalmic Treatment 有权
    功能性纳米组合物用于眼科治疗

    公开(公告)号:US20100221344A1

    公开(公告)日:2010-09-02

    申请号:US12147759

    申请日:2008-06-27

    IPC分类号: A61K9/14 A61P27/02

    摘要: The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing said plurality of nanoceria particles with associated inhibitor. One preferred inhibitor of human carbonic anhydrase II comprises 4-carboxybenzene sulfonamide. The disclosed composition is useful in treatment of glaucoma.

    摘要翻译: 本发明提供一种组合物,其包含多个纳米颗粒,足量的至少一种与所述多个纳米颗粒相关联的人碳酸酐酶II抑制剂,以及含有所述多个具有相关抑制剂的纳米颗粒的药学上可接受的载体。 人碳酸酐酶II的一种优选抑制剂包括4-羧基苯磺酰胺。 所公开的组合物可用于治疗青光眼。

    Functionalized nanoceria composition for ophthalmic treatment
    2.
    发明授权
    Functionalized nanoceria composition for ophthalmic treatment 有权
    用于眼科治疗的功能性纳米组合物

    公开(公告)号:US08795737B2

    公开(公告)日:2014-08-05

    申请号:US13724750

    申请日:2012-12-21

    IPC分类号: A61K33/34

    摘要: The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing said plurality of nanoceria particles with associated inhibitor. One preferred inhibitor of human carbonic anhydrase II comprises 4-carboxybenzene sulfonamide. The disclosed composition is useful in treatment of glaucoma.

    摘要翻译: 本发明提供一种组合物,其包含多个纳米颗粒,足量的至少一种与所述多个纳米颗粒相关联的人碳酸酐酶II抑制剂,以及含有所述多个具有相关抑制剂的纳米颗粒的药学上可接受的载体。 人碳酸酐酶II的一种优选抑制剂包括4-羧基苯磺酰胺。 所公开的组合物可用于治疗青光眼。

    FUNCTIONALIZED NANOCERIA COMPOSITION FOR OPHTHALMIC TREATMENT
    3.
    发明申请
    FUNCTIONALIZED NANOCERIA COMPOSITION FOR OPHTHALMIC TREATMENT 有权
    功能性纳米组合物用于眼科治疗

    公开(公告)号:US20130123515A1

    公开(公告)日:2013-05-16

    申请号:US13724750

    申请日:2012-12-21

    IPC分类号: C07F5/00

    摘要: The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing said plurality of nanoceria particles with associated inhibitor. One preferred inhibitor of human carbonic anhydrase II comprises 4-carboxybenzene sulfonamide. The disclosed composition is useful in treatment of glaucoma.

    摘要翻译: 本发明提供一种组合物,其包含多个纳米颗粒,足量的至少一种与所述多个纳米颗粒相关联的人碳酸酐酶II抑制剂,以及含有所述多个具有相关抑制剂的纳米颗粒的药学上可接受的载体。 人碳酸酐酶II的一种优选抑制剂包括4-羧基苯磺酰胺。 所公开的组合物可用于治疗青光眼。

    Functionalized nanoceria composition for ophthalmic treatment
    4.
    发明授权
    Functionalized nanoceria composition for ophthalmic treatment 有权
    用于眼科治疗的功能性纳米组合物

    公开(公告)号:US08337898B2

    公开(公告)日:2012-12-25

    申请号:US13154849

    申请日:2011-06-07

    IPC分类号: A61K9/14 A01N59/16

    摘要: The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing said plurality of nanoceria particles with associated inhibitor. One preferred inhibitor of human carbonic anhydrase II comprises 4-carboxybenzene sulfonamide. The disclosed composition is useful in treatment of glaucoma.

    摘要翻译: 本发明提供一种组合物,其包含多个纳米颗粒,足量的至少一种与所述多个纳米颗粒相关联的人碳酸酐酶II抑制剂,以及含有所述多个具有相关抑制剂的纳米颗粒的药学上可接受的载体。 人碳酸酐酶II的一种优选抑制剂包括4-羧基苯磺酰胺。 所公开的组合物可用于治疗青光眼。

    Surfactant incorporated nanostructure for pressure drop reduction in oil and gas lines
    5.
    发明授权
    Surfactant incorporated nanostructure for pressure drop reduction in oil and gas lines 失效
    表面活性剂纳入了油气管线压降降低的纳米结构

    公开(公告)号:US08252259B2

    公开(公告)日:2012-08-28

    申请号:US12290501

    申请日:2008-10-31

    IPC分类号: C01F17/00

    CPC分类号: F17D1/16 Y10T137/0391

    摘要: Nano-sized rare earth metal oxide particles are prepared from aqueous reverse micelles. The engineered nanoparticles have large surface area to volume ratios, and uniformly incorporate a surfactant in each particle, so that when applied to the inner surface of a pipeline or sprayed onto a fluid stream in a pipeline, the particles reduce the roughness of the inside surface of pipe being used to transport fluid. The application of a nanolayer of this novel nanoceria mixture causes a significant reduction in pressure drops, friction, and better recovery and yield of fluid flowing through a pipeline.

    摘要翻译: 由水性反胶束制备纳米级稀土金属氧化物颗粒。 工程纳米颗粒具有大的表面积与体积比,并且在每个颗粒中均匀地加入表面活性剂,使得当施用到管道的内表面或喷射到管道中的流体流时,颗粒减小了内表面的粗糙度 的管道用于运输流体。 这种新型纳米碳混合物的纳米层的应用导致压降,摩擦力以及流过管道的流体的更好的回收率和产量的显着降低。

    Functionalized nanoceria composition for ophthalmic treatment
    7.
    发明授权
    Functionalized nanoceria composition for ophthalmic treatment 有权
    用于眼科治疗的功能性纳米组合物

    公开(公告)号:US07959949B2

    公开(公告)日:2011-06-14

    申请号:US12147759

    申请日:2008-06-27

    IPC分类号: A61K9/14 A61K33/24

    摘要: The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing said plurality of nanoceria particles with associated inhibitor. One preferred inhibitor of human carbonic anhydrase II comprises 4-carboxybenzene sulfonamide. The disclosed composition is useful in treatment of glaucoma.

    摘要翻译: 本发明提供一种组合物,其包含多个纳米颗粒,足量的至少一种与所述多个纳米颗粒相关联的人碳酸酐酶II抑制剂,以及含有所述多个具有相关抑制剂的纳米颗粒的药学上可接受的载体。 人碳酸酐酶II的一种优选抑制剂包括4-羧基苯磺酰胺。 所公开的组合物可用于治疗青光眼。

    Surfactant incorporated nanostructure for pressure drop reduction in oil and gas lines
    8.
    发明申请
    Surfactant incorporated nanostructure for pressure drop reduction in oil and gas lines 失效
    表面活性剂纳入了油气管线压降降低的纳米结构

    公开(公告)号:US20090127505A1

    公开(公告)日:2009-05-21

    申请号:US12290501

    申请日:2008-10-31

    IPC分类号: C09K3/00

    CPC分类号: F17D1/16 Y10T137/0391

    摘要: Nano-sized rare earth metal oxide particles are prepared from aqueous reverse micelles. The engineered nanoparticles have large surface area to volume ratios, and uniformly incorporate a surfactant in each particle, so that when applied to the inner surface of a pipeline or sprayed onto a fluid stream in a pipeline, the particles reduce the roughness of the inside surface of pipe being used to transport fluid. The application of a nanolayer of this novel nanoceria mixture causes a significant reduction in pressure drops, friction, and better recovery and yield of fluid flowing through a pipeline.

    摘要翻译: 由水性反胶束制备纳米级稀土金属氧化物颗粒。 工程纳米颗粒具有大的表面积与体积比,并且在每个颗粒中均匀地加入表面活性剂,使得当施用到管道的内表面或喷射到管道中的流体流时,颗粒减小了内表面的粗糙度 的管道用于运输流体。 这种新型纳米碳混合物的纳米层的应用导致压降,摩擦力以及流过管道的流体的更好的回收率和产量的显着降低。