公开(公告)号：US20060088565A1

公开(公告)日：2006-04-27

申请号：US10496399

申请日：2002-03-27

申请人： Ulrich Kohnert ,  Sylke Pohling ,  Klaus Hellerbrand ,  Peter Happersberger

发明人： Ulrich Kohnert ,  Sylke Pohling ,  Klaus Hellerbrand ,  Peter Happersberger

IPC分类号： A61K38/17 ,  A61K8/96 ,  A61K31/7012

CPC分类号： A61L27/227 ,  A61L24/02 ,  A61L24/108 ,  A61L27/12 ,  A61L27/34

摘要： The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein said carrier is homogenously coated with said protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and osteoconductive properties in vivo. The invention encompasses a pharmaceutical composition comprising the device of the invention or a device which is obtainable by the method of the invention and relates to the use of said device for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the device of the invention or a device which is obtainable by the method of the invention.

摘要翻译： 本发明涉及一种在体内具有骨诱导和骨传导性质的装置，其包含含有磷酸钙和骨诱导蛋白的载体，其中所述载体均匀地涂覆有所述蛋白质。 此外，本发明涉及在体内制造具有骨诱导性和骨传导性的装置的方法。 本发明包括药物组合物，其包含本发明的装置或可通过本发明的方法获得的装置，并且涉及所述装置用于制备用于骨增大的药物组合物用于治疗骨缺损的用途 用于治疗退行性和创伤性椎间盘疾病，用于治疗骨开裂或用于窦底抬高。 最后，本发明涉及包含本发明的装置或可通过本发明的方法获得的装置的试剂盒。

公开(公告)号：US08546334B2

公开(公告)日：2013-10-01

申请号：US10496399

申请日：2002-03-27

申请人： Ulrich Kohnert ,  Sylke Pohling ,  Klaus Hellerbrand ,  Peter Happersberger

发明人： Ulrich Kohnert ,  Sylke Pohling ,  Klaus Hellerbrand ,  Peter Happersberger

IPC分类号： A61K38/19 ,  A61K47/02 ,  C07K14/51 ,  A61P19/08

CPC分类号： A61L27/227 ,  A61L24/02 ,  A61L24/108 ,  A61L27/12 ,  A61L27/34

摘要： The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein the carrier is homogenously coated with the protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and osteoconductive properties in vivo. The invention encompasses a pharmaceutical composition comprising the device of the invention or a device which is obtainable by the method of the invention and relates to the use of the device for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the device of the invention or a device which is obtainable by the method of the invention.

摘要翻译： 本发明涉及一种在体内具有骨诱导和骨传导性质的装置，其包含含有磷酸钙和骨诱导蛋白的载体，其中载体均匀地被蛋白质包被。 此外，本发明涉及在体内制造具有骨诱导性和骨传导性的装置的方法。 本发明包括药物组合物，其包含本发明的装置或可通过本发明的方法获得的装置，涉及该装置用于制备用于骨增大的药物组合物的用途，用于治疗骨缺损 用于治疗退行性和创伤性椎间盘疾病，用于治疗骨开裂或用于窦底抬高。 最后，本发明涉及包含本发明的装置或可通过本发明的方法获得的装置的试剂盒。