公开(公告)号：US20050119279A1

公开(公告)日：2005-06-02

申请号：US10957255

申请日：2004-10-01

申请人： T. G. Dhar ,  Edwin Iwanowicz ,  Michele Launay ,  Dominique Potin ,  Magali Blandine Maillet ,  Eric Nicolai

发明人： T. G. Dhar ,  Edwin Iwanowicz ,  Michele Launay ,  Dominique Potin ,  Magali Blandine Maillet ,  Eric Nicolai

IPC分类号： C07D498/20 ,  C07D513/20 ,  A61K31/519 ,  A61K31/4188 ,  A61K31/4747 ,  C07D487/12

CPC分类号： C07D498/20 ,  C07D513/20

摘要： The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is —C(═O)— or optionally substituted C1-6alkylene; Ar is optionally-substituted aryl or heteroaryl; J1, J2, J3 and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; R1 is N or C(R9); and R2, and R3, are as defined in the specification.

摘要翻译： 本发明涉及具有式（I）的化合物：可用于治疗其中K和L独立地为O或S的炎症和免疫疾病; Q是-C（-O） - 或任选取代的C 1-6 - 亚烷基; Ar是任选取代的芳基或杂芳基; 选择J 1，J 2，J 3和Y，使得环A为5至6元任选取代的环烯基或 具有0至2个氮杂原子的杂环; R 1是N或C（R 9）; 和R 2 R 3和R 3'如说明书中所定义。

公开(公告)号：US20060052434A1

公开(公告)日：2006-03-09

申请号：US11206558

申请日：2005-08-18

申请人： T. G. Dhar ,  Dharmpal Dodd ,  Dominique Potin ,  Michele Launay

发明人： T. G. Dhar ,  Dharmpal Dodd ,  Dominique Potin ,  Michele Launay

IPC分类号： A61K31/407 ,  C07D487/02

CPC分类号： C07D487/04 ,  A61K31/407

摘要： Pyrrolizine compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective in treating inflammatory or immune diseases, where A is a four- to seven-membered saturated ring, K is O or S, and R1, R2, R3 n, and M are defined in the specification.

摘要翻译： 具有式（I）的吡咯烷化合物，