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公开(公告)号：US08105805B2
公开(公告)日：2012-01-31
申请号：US13184603
申请日：2011-07-18
申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikluka
发明人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikluka
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.
摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR） ，29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列 ，删除或添加。
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公开(公告)号：US20100034833A1
公开(公告)日：2010-02-11
申请号：US12577788
申请日：2009-10-13
申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
发明人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.
摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离的抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR） ，29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列 ，删除或添加。
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公开(公告)号：US20110269187A1
公开(公告)日：2011-11-03
申请号：US13184603
申请日：2011-07-18
申请人： TAMMY H. HUANG , SEAN STEVENS , JOEL H. MARTIN , JEANETTE L. FAIRHURST , KEVIN J. POBURSKY , MARGARET KAROW , JOAN A. WINDSOR , WARREN R. MIKLUKA
发明人： TAMMY H. HUANG , SEAN STEVENS , JOEL H. MARTIN , JEANETTE L. FAIRHURST , KEVIN J. POBURSKY , MARGARET KAROW , JOAN A. WINDSOR , WARREN R. MIKLUKA
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.
摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR） ，29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列 ，删除或添加。
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公开(公告)号：US08003103B2
公开(公告)日：2011-08-23
申请号：US12577788
申请日：2009-10-13
申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
发明人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.
摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR） ，29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列 ，删除或添加。
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公开(公告)号：US07615220B2
公开(公告)日：2009-11-10
申请号：US11784308
申请日：2007-04-06
申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
发明人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.
摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离的抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR） ，29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列 ，删除或添加。
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