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公开(公告)号:US20160327558A1
公开(公告)日:2016-11-10
申请号:US15108655
申请日:2015-01-20
申请人: Helmholtz Zentrum Munchen Deutches Forschungszentrum fur Gesundheit und Umwelt (GmbH) , TECHNISCHE UNIVERSITÄT MÜNCHE
IPC分类号: G01N33/573
CPC分类号: G01N33/573 , C07K2319/43 , C07K2319/60 , C12N9/6472 , G01N33/532 , G01N2333/96466 , G01N2800/00 , G01N2800/52
摘要: The present invention provides means and methods for selectively detecting activated MALT1 in a sample. Moreover, the present invention provides a method for diagnosing diseases, which are characterized by an increased MALT1 activity. Finally, the present invention provides methods for identifying patients which are amenable to treatment with a therapeutic agent capable of inhibiting MALT1 activity.
摘要翻译: 本发明提供用于选择性地检测样品中活化的MALT1的方法和方法。 此外,本发明提供一种诊断疾病的方法,其特征在于MALT1活性升高。 最后,本发明提供了用于鉴定适于用能够抑制MALT1活性的治疗剂治疗的患者的方法。