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公开(公告)号：US08337850B2
公开(公告)日：2012-12-25
申请号：US13228532
申请日：2011-09-09
申请人： Bianca Ahrens , Sangita M. Baxi , Timothy Scott Fisher , Richard Michael Jerome , Kathrin Ladetzki-Baehs , Theodore Oliphant , Leslie Lynne Sharp , Michael Tesar , Libbey Anne Yates , Moritz Zulley
发明人： Bianca Ahrens , Sangita M. Baxi , Timothy Scott Fisher , Richard Michael Jerome , Kathrin Ladetzki-Baehs , Theodore Oliphant , Leslie Lynne Sharp , Michael Tesar , Libbey Anne Yates , Moritz Zulley
IPC分类号： A61K39/395 , C07K16/28 , C12P21/02
CPC分类号： C07K16/2878 , A61K38/02 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/2887 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/74 , C07K2317/75 , C07K2317/92 , C12N5/06 , C12N15/62
摘要： The present disclosure provides isolated binding molecules that bind to human 4-1BB, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
摘要翻译： 本公开提供了结合人4-1BB的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，药物组合物 含有结合分子的方法和使用结合分子或组合物的方法。
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公开(公告)号：US20120237498A1
公开(公告)日：2012-09-20
申请号：US13228532
申请日：2011-09-09
申请人： Bianca AHRENS , Sangita M. BAXI , Timothy Scott FISHER , Richard Michael JEROME , Kathrin LADETZKI-BAEHS , Theodore OLIPHANT , Leslie Lynne SHARP , Michael TESAR , Libbey Anne YATES , Moritz ZULLEY
发明人： Bianca AHRENS , Sangita M. BAXI , Timothy Scott FISHER , Richard Michael JEROME , Kathrin LADETZKI-BAEHS , Theodore OLIPHANT , Leslie Lynne SHARP , Michael TESAR , Libbey Anne YATES , Moritz ZULLEY
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/2878 , A61K38/02 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/2887 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/74 , C07K2317/75 , C07K2317/92 , C12N5/06 , C12N15/62
摘要： The present disclosure provides isolated binding molecules that bind to human 4-1BB, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
摘要翻译： 本公开提供了结合人4-1BB的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，药物组合物 含有结合分子的方法和使用结合分子或组合物的方法。
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3.发明申请ANTIBODIES AGAINST WEST NILE VIRUS AND THERAPEUTIC AND PROPHYLACTIC USES THEREOF 审中-公开抗西兰病毒的抗体及其治疗和预防用途公开(公告)号：US20120076758A1
公开(公告)日：2012-03-29
申请号：US13097337
申请日：2011-04-29
IPC分类号： A61K38/21 , C12N15/13 , C12N15/63 , A61K39/42 , C12N1/19 , C12P21/08 , C12Q1/70 , C12N1/21 , C12N5/10 , C07K16/10 , A61P31/14
CPC分类号： C07K16/1081 , A61K2039/505 , C07K2317/734 , C07K2317/76 , Y02A50/394
摘要： The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV), infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.
摘要翻译： 本发明涉及包含免疫特异性结合黄病毒，特别是西尼罗病毒（WNV）的一种或多种抗原的抗体或其片段的组合物，以及用于预防，治疗或改善黄病毒特别是西尼罗病毒症状的方法 病毒（WNV），利用所述组合物的感染。 特别地，本发明涉及用于预防，治疗或改善与WNV感染相关的症状的方法，所述方法包括向人类受试者施用有效量的一种或多种免疫特异性结合WNV抗原的抗体或其片段。 本发明还涉及包含免疫特异性结合WNV抗原的抗体或其片段的可检测或诊断组合物，以及利用所述组合物检测或诊断WNV感染的方法。
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4.发明授权Antibodies against West Nile Virus and therapeutic and prophylactic uses thereof 有权抗西尼罗病毒抗体及其治疗和预防用途公开(公告)号：US07981422B2
公开(公告)日：2011-07-19
申请号：US12385346
申请日：2009-04-06
IPC分类号： A61K39/42
CPC分类号： C07K16/1081 , A61K2039/505 , C07K2317/734 , C07K2317/76 , Y02A50/394
摘要： The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV), infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.
摘要翻译： 本发明涉及包含免疫特异性结合黄病毒，特别是西尼罗病毒（WNV）的一种或多种抗原的抗体或其片段的组合物，以及用于预防，治疗或改善黄病毒特别是西尼罗病毒症状的方法 病毒（WNV），利用所述组合物的感染。 特别地，本发明涉及用于预防，治疗或改善与WNV感染相关的症状的方法，所述方法包括向人类受试者施用有效量的一种或多种免疫特异性结合WNV抗原的抗体或其片段。 本发明还涉及包含免疫特异性结合WNV抗原的抗体或其片段的可检测或诊断组合物，以及利用所述组合物检测或诊断WNV感染的方法。
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5.发明申请Antibodies against west nile virus and therapeutic and prophylactic uses thereof 有权抗西尼罗病毒的抗体及其治疗和预防用途公开(公告)号：US20090258011A1
公开(公告)日：2009-10-15
申请号：US12385346
申请日：2009-04-06
CPC分类号： C07K16/1081 , A61K2039/505 , C07K2317/734 , C07K2317/76 , Y02A50/394
摘要： The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV), infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.
摘要翻译： 本发明涉及包含免疫特异性结合黄病毒，特别是西尼罗病毒（WNV）的一种或多种抗原的抗体或其片段的组合物，以及用于预防，治疗或改善黄病毒特别是西尼罗病毒症状的方法 病毒（WNV），利用所述组合物的感染。 特别地，本发明涉及用于预防，治疗或改善与WNV感染相关的症状的方法，所述方法包括向人类受试者施用有效量的一种或多种免疫特异性结合WNV抗原的抗体或其片段。 本发明还涉及包含免疫特异性结合WNV抗原的抗体或其片段的可检测或诊断组合物，以及利用所述组合物检测或诊断WNV感染的方法。
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6.发明授权Antibodies against West Nile Virus and therapeutic and prophylactic uses thereof 有权抗西尼罗病毒抗体及其治疗和预防用途公开(公告)号：US07527973B2
公开(公告)日：2009-05-05
申请号：US11159046
申请日：2005-06-21
IPC分类号： C12N5/06 , C12N5/10 , C12P21/01 , A61K49/00 , A61K39/395 , A61K39/42 , A61K39/12 , A61K39/193
CPC分类号： C07K16/1081 , A61K2039/505 , C07K2317/734 , C07K2317/76 , Y02A50/394
摘要： The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV), infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.
摘要翻译： 本发明涉及包含免疫特异性结合黄病毒，特别是西尼罗病毒（WNV）的一种或多种抗原的抗体或其片段的组合物，以及用于预防，治疗或改善黄病毒特别是西尼罗病毒症状的方法 病毒（WNV），利用所述组合物的感染。 特别地，本发明涉及用于预防，治疗或改善与WNV感染相关的症状的方法，所述方法包括向人类受试者施用有效量的一种或多种免疫特异性结合WNV抗原的抗体或其片段。 本发明还涉及包含免疫特异性结合WNV抗原的抗体或其片段的可检测或诊断组合物，以及利用所述组合物检测或诊断WNV感染的方法。
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公开(公告)号：US20060067940A1
公开(公告)日：2006-03-30
申请号：US11159046
申请日：2005-06-21
CPC分类号： C07K16/1081 , A61K2039/505 , C07K2317/734 , C07K2317/76 , Y02A50/394
摘要： The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV), infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.
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