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公开(公告)号：US20240175072A1
公开(公告)日：2024-05-30
申请号：US18254135
申请日：2021-12-09
发明人： Michael Stadnisky , Craig LaBODA , Nicholas PINKIN , Ivan GODINEZ
IPC分类号： C12Q1/6804
CPC分类号： C12Q1/6804
摘要： Provided herein are multimodal methods and compositions that combine sequence-tagged antibodies and fluorescent labels in a single reagent. Combined with optimal panel design, high-purity sorting of cells before sequencing has been demonstrated, and furthermore, truly quantitative information on the cell surface markers used for sorting.
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公开(公告)号：USD1020785S1
公开(公告)日：2024-04-02
申请号：US29870227
申请日：2023-01-19
摘要： The sole FIGURE is a front view of our new display screen of a biological safety cabinet with graphical user interface design.
The outer rectangle shown in broken lines illustrates the display screen of a biological safety cabinet. The remaining broken lines illustrate features of the graphical user interface applied thereto that are excluded from the claim. The broken-line subject matter forms no part of the claimed design.-
公开(公告)号：USD1007525S1
公开(公告)日：2023-12-12
申请号：US29870218
申请日：2023-01-19
摘要： The sole FIGURE is a front view of a display screen of a biological safety cabinet with graphical user interface design.
The outer rectangle shown in broken lines illustrates the display screen of a biological safety cabinet. The remaining broken lines illustrate features of the graphical user interface applied thereto that are excluded from the claim. The broken-line subject matter forms no part of the claimed design.-
公开(公告)号：US20220315922A1
公开(公告)日：2022-10-06
申请号：US17520530
申请日：2021-11-05
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113 , A61K31/713 , C12N15/10 , C12N15/11 , A61K48/00
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
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公开(公告)号：US20190233829A1
公开(公告)日：2019-08-01
申请号：US16378629
申请日：2019-04-09
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N2310/122 , C12N2310/141
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for COX-2.
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公开(公告)号：US10288555B2
公开(公告)日：2019-05-14
申请号：US15786238
申请日：2017-10-17
IPC分类号： G01N21/00 , G01N21/29 , B65D55/02 , G01N21/01 , G01N21/63 , G09F3/00 , G09F3/03 , B07C5/00 , B65B51/00 , B65B57/00 , G01N21/90 , G01N21/956
摘要： A tamper seal detection system for detecting a sealing sticker on a packaging box includes a housing at least partially bounding an inspection zone, the inspection zone being configured to receive the packaging box. A first sensor is configured to detect the presence of the first sealing sticker located on the packaging box when the packaging box is received within the inspection zone. A push guide is movable relative to the inspection floor between a first position and a spaced apart second position and can be used to push the packaging box out of the inspection zone.
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公开(公告)号：US10035617B1
公开(公告)日：2018-07-31
申请号：US15421721
申请日：2017-02-01
发明人： Martin Shipp
摘要： A method for detecting sealing stickers on a packaging box includes placing a first packaging box onto a conveyor belt of a conveyor belt system at an inspection zone, the first packaging box having a first sealing sticker thereon that at least partially seals the first packaging box closed; and activating a first optical sensor to detect whether the first sealing sticker is located on a first side of the first packaging box while the packaging box is in the inspection zone.
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公开(公告)号：US09719094B2
公开(公告)日：2017-08-01
申请号：US15255973
申请日：2016-09-02
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , A61K31/713
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/14
摘要： Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for SEC61G.
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9.发明申请公开(公告)号：US20160201058A1
公开(公告)日：2016-07-14
申请号：US14965816
申请日：2015-12-10
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对TTR的核苷酸序列的那些。
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公开(公告)号：US09360406B2
公开(公告)日：2016-06-07
申请号：US13864459
申请日：2013-04-17
发明人： Alex Kulik , Michael George Brosseau , Hai Wang
摘要： A process and system for self-calibration of a density profiler is disclosed. The process may include measuring a density profile of a fluid in a vessel using a plurality of sensors or a single sensor, and measuring a density profile of the fluid in the vessel using a plurality of sample ports. A density of the fluid proximate a location of at least one of the plurality of sample ports based on the sensor measured density profile may then be interpolated. A density of the fluid proximate a location of at least one of the plurality of sensors based on the sample port measured density profile may also be interpolated. Adjustment of a calibration of at least one of the plurality of sensors may then be made based on both the interpolated sample port density and the interpolated sensor density.
摘要翻译： 公开了用于密度分析器的自校准的过程和系统。 该过程可以包括使用多个传感器或单个传感器来测量容器中的流体的密度分布，并且使用多个样品端口测量容器中的流体的密度分布。 然后可以内插基于传感器测量密度分布的多个采样端口中至少一个的位置附近的流体的密度。 基于样本端口测量的密度分布，接近于多个传感器中的至少一个的位置的流体的密度也可被内插。 然后可以基于插值的采样端口密度和内插的传感器密度来对多个传感器中的至少一个的校准进行调整。
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