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1.发明申请Prostate Cancer-Specific Alternations in ERG Gene Expression and Detection and Treatment Methods Based on Those Alterations 有权前列腺癌特异性的ERG基因表达改变和基于这些变化的检测和治疗方法公开(公告)号：US20100144832A1
公开(公告)日：2010-06-10
申请号：US12444903
申请日：2007-10-09
申请人： Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
发明人： Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
IPC分类号： A61K31/7105 , C12Q1/68 , C07H21/02 , C07K14/00 , C07K16/00 , A61K31/711 , C07H21/04 , A61P35/00
CPC分类号： C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The disclosure further provides therapeutic compositions and methods of detecting, diagnosing, prognosing, and treating prostate cancer, including biomarkers for detecting the expression of two or more of the following genes: PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG.
摘要翻译： 本公开描述了ERG基因表达的改变。 提供参与或与前列腺癌相关的ERG同种型和ERG基因的启动子序列。 本发明还提供了检测，诊断，预后和治疗前列腺癌的治疗组合物和方法，包括用于检测以下两种或更多基因表达的生物标志物：PSA / KLK3，PMEPA1，NKX3.1，ODC1，AMD1和 尔格。
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2.发明授权Prostate cancer-specific alternations in ERG gene expression and detection and treatment methods based on those alterations 有权前列腺癌特异性的ERG基因表达变化和基于这些改变的检测和治疗方法公开(公告)号：US08541169B2
公开(公告)日：2013-09-24
申请号：US12444903
申请日：2007-10-09
申请人： Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
发明人： Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
IPC分类号： C12Q1/68
CPC分类号： C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The disclosure further provides therapeutic compositions and methods of detecting, diagnosing, prognosing, and treating prostate cancer, including biomarkers for detecting the expression of two or more of the following genes: PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG.
摘要翻译： 本公开描述了ERG基因表达的改变。 提供参与或与前列腺癌相关的ERG同种型和ERG基因的启动子序列。 本发明还提供了检测，诊断，预后和治疗前列腺癌的治疗组合物和方法，包括用于检测以下两种或更多基因表达的生物标志物：PSA / KLK3，PMEPA1，NKX3.1，ODC1，AMD1和 尔格。
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3.发明申请Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those alterations 有权前列腺癌特异性改变ERG基因表达和基于这些改变的检测和治疗方法公开(公告)号：US20080269157A1
公开(公告)日：2008-10-30
申请号：US12081101
申请日：2008-04-10
申请人： Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
发明人： Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
CPC分类号： C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： Alterations in ERG gene expression can be observed in patients with prostate cancer. Specific ERG isoforms are associated with, or involved in, prostate cancer. Compositions comprising these isoforms provide therapeutic benefit and can be used in methods of detecting, diagnosing, prognosing, and treating prostate cancer. These compositions provide biomarkers for detecting the expression of combinations of the PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG genes.
摘要翻译： ERG基因表达的改变可以在前列腺癌患者中观察到。 特异性ERG同种型与前列腺癌相关或涉及前列腺癌。 包含这些同种型的组合物提供治疗益处，并且可用于检测，诊断，预后和治疗前列腺癌的方法。 这些组合物提供用于检测PSA / KLK3，PMEPA1，NKX3.1，ODC1，AMD1和ERG基因组合的表达的生物标志物。
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4.发明授权Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those alterations 有权前列腺癌特异性改变ERG基因表达和基于这些改变的检测和治疗方法公开(公告)号：US09206481B2
公开(公告)日：2015-12-08
申请号：US12081101
申请日：2008-04-10
申请人： Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
发明人： Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
IPC分类号： C12Q1/68
CPC分类号： C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： Alterations in ERG gene expression can be observed in patients with prostate cancer. Specific ERG isoforms are associated with, or involved in, prostate cancer. Compositions comprising these isoforms provide therapeutic benefit and can be used in methods of detecting, diagnosing, prognosing, and treating prostate cancer. These compositions provide biomarkers for detecting the expression of combinations of the PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG genes.
摘要翻译： ERG基因表达的改变可以在前列腺癌患者中观察到。 特异性ERG同种型与前列腺癌相关或涉及前列腺癌。 包含这些同种型的组合物提供治疗益处，并且可用于检测，诊断，预后和治疗前列腺癌的方法。 这些组合物提供用于检测PSA / KLK3，PMEPA1，NKX3.1，ODC1，AMD1和ERG基因组合的表达的生物标志物。
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