公开(公告)号：US07868196B2

公开(公告)日：2011-01-11

申请号：US11989074

申请日：2006-07-18

申请人： Tae-Suk Lee ,  Jin-Soo Yook ,  Jong-Soo Lee ,  Chang-Hyun Yoo ,  Ju-Cheol Lee ,  Cheol-Min Lee ,  Wan-Hee Lee

发明人： Tae-Suk Lee ,  Jin-Soo Yook ,  Jong-Soo Lee ,  Chang-Hyun Yoo ,  Ju-Cheol Lee ,  Cheol-Min Lee ,  Wan-Hee Lee

IPC分类号： C07F9/02

CPC分类号： C11C3/04

摘要： Disclosed is a process for the regioselective preparation of glycerol derivative in a high efficiency and yield. The process for the regioselective preparation of 1-R1-2-R2-3-acetyl-glycerol derivative comprises the steps of: obtaining 1-R1-3-protecting group-glycerol by introducing a protecting group to 3-position of 1-R1-glycerol; obtaining 1-R1-2-R2-3-protecting group-glycerol by introducing R2 group into 2-position of 1-R1-3-protecting group-glycerol; and carrying out the deprotection reaction and the acetylation reaction of 1-R1-2-R2-3-protecting group-glycerol at the same time. Wherein, R1 and R2 are fatty acid groups having 16 to 22 carbon atoms, and are different from each other; and the protecting group is trityl group or trialkylsilyl group.

摘要翻译： 公开了以高效率和高产率区域选择性制备甘油衍生物的方法。 1-R1-2-R2-3-乙酰基 - 甘油衍生物的区域选择性制备方法包括以下步骤：通过将保护基引入1-R1的3-位获得1-R1-3保护基 - 甘油 甘油 通过将R2基团引入1-R1-3保护基 - 甘油的2-位获得1-R1-2-R2-3-保护基 - 甘油; 并同时进行1-R1-2-R2-3-保护基 - 甘油的去保护反应和乙酰化反应。 其中R1和R2是具有16-22个碳原子的脂肪酸基团，并且彼此不同; 保护基为三苯甲基或三烷基甲硅烷基。

公开(公告)号：US20090253923A1

公开(公告)日：2009-10-08

申请号：US11989074

申请日：2006-07-18

申请人： Tae-Suk Lee ,  Jin-Soo Yook ,  Jong-Soo Lee ,  Chang-Hyun Yoo ,  Ju-Cheol Lee ,  Cheol-Min Lee ,  Wan-Hee Lee

发明人： Tae-Suk Lee ,  Jin-Soo Yook ,  Jong-Soo Lee ,  Chang-Hyun Yoo ,  Ju-Cheol Lee ,  Cheol-Min Lee ,  Wan-Hee Lee

IPC分类号： C07F9/02

CPC分类号： C11C3/04

摘要： Disclosed is a process for the regioselective preparation of glycerol derivative in a high efficiency and yield. The process for the regioselective preparation of 1-R1-2-R2-3-acetyl-glycerol derivative comprises the steps of: obtaining 1-R1-3-protecting group-glycerol by introducing a protecting group to 3-position of 1-R1-glycerol; obtaining 1-R1-2-R2-3-protecting group-glycerol by introducing R2 group into 2-position of 1-R1-3-protecting group-glycerol; and carrying out the deprotection reaction and the acetylation reaction of 1-R1-2-R2-3-protecting group-glycerol at the same time. Wherein, R1 and R2 are fatty acid groups having 16 to 22 carbon atoms, and are different from each other; and the protecting group is trityl group or trialkylsilyl group.

摘要翻译： 公开了以高效率和高产率区域选择性制备甘油衍生物的方法。 1-R1-2-R2-3-乙酰基 - 甘油衍生物的区域选择性制备方法包括以下步骤：通过将保护基引入1-R1的3-位获得1-R1-3-保护基 - 甘油 甘油 通过将R2基团引入1-R1-3保护基 - 甘油的2-位获得1-R1-2-R2-3-保护基 - 甘油; 并同时进行1-R1-2-R2-3-保护基 - 甘油的去保护反应和乙酰化反应。 其中R1和R2是具有16-22个碳原子的脂肪酸基团，并且彼此不同; 保护基为三苯甲基或三烷基甲硅烷基。

公开(公告)号：US20120004838A1

公开(公告)日：2012-01-05

申请号：US12954473

申请日：2010-11-24

申请人： Tae Suk Lee ,  Jin Ho Ha

发明人： Tae Suk Lee ,  Jin Ho Ha

IPC分类号： G06F19/00

CPC分类号： G08G1/096844 ,  G01C21/3469 ,  G01F9/023

摘要： The invention provides a system for calculating a fuel amount of a travel route that may estimate and calculate a fuel consumption amount by road sections according to a traffic situation, and a method thereof.

摘要翻译： 本发明提供一种用于计算可以根据交通情况估计并计算路段的燃料消耗量的行驶路线的燃料量的系统及其方法。

公开(公告)号：US06600025B1

公开(公告)日：2003-07-29

申请号：US09856383

申请日：2001-09-06

申请人： Tae Suk Lee ,  Chang Hyun Yoo ,  Kyoung Soo Kim ,  Hyun Suk An ,  Jung Young Kim ,  Wan Joo Kim

发明人： Tae Suk Lee ,  Chang Hyun Yoo ,  Kyoung Soo Kim ,  Hyun Suk An ,  Jung Young Kim ,  Wan Joo Kim

IPC分类号： C07H100

CPC分类号： C07H17/08 ,  Y02P20/55

摘要： An erythromycin A 9-O-benzodithiol oxime intermediate represented by the following formula (III) useful for synthesis of clarthromycin and crystalline solvate thereof: Wherein, Y1 and Y2 are independently a hydrogen atoms or trimethylsilyl groups. And, a process for the preparation of clarithromycin using the erythromycin A 9-O-benzodithiol oxime intermediate as described in the specification.

摘要翻译： 用于合成克拉霉素及其结晶溶剂化物的下式（III）表示的红霉素A 9-O-苯并二硫醇肟中间体：其中Y1和Y2独立地为氢原子或三甲基甲硅烷基。 而且，如本说明书所述，使用红霉素A 9-O-苯并二硫醇肟中间体制备克拉霉素的方法。

公开(公告)号：US06506886B1

公开(公告)日：2003-01-14

申请号：US09786636

申请日：2001-03-07

申请人： Tae-Suk Lee ,  Ju-Cheol Lee ,  Kyoung-Ik Lee ,  Gwan-Sun Lee ,  Wan-Joo Kim

发明人： Tae-Suk Lee ,  Ju-Cheol Lee ,  Kyoung-Ik Lee ,  Gwan-Sun Lee ,  Wan-Joo Kim

IPC分类号： C07M100

CPC分类号： C07H17/08

摘要： Form II crystals of clarithromycin can be easily prepared by treating clarithromycin of different crystal forms with water or with a mixture of water and a water-immiscible organic solvent and isolating treated crystals by filtration.

摘要翻译： 克拉霉素II型晶体可以通过用水或水与水不混溶的有机溶剂的混合物处理不同晶型的克拉霉素并通过过滤分离处理的晶体来容易地制备。