Preparation of glycerol derivatives and intermediates therefor
    2.
    发明授权
    Preparation of glycerol derivatives and intermediates therefor 有权
    甘油衍生物及其中间体的制备

    公开(公告)号:US07868196B2

    公开(公告)日:2011-01-11

    申请号:US11989074

    申请日:2006-07-18

    IPC分类号: C07F9/02

    CPC分类号: C11C3/04

    摘要: Disclosed is a process for the regioselective preparation of glycerol derivative in a high efficiency and yield. The process for the regioselective preparation of 1-R1-2-R2-3-acetyl-glycerol derivative comprises the steps of: obtaining 1-R1-3-protecting group-glycerol by introducing a protecting group to 3-position of 1-R1-glycerol; obtaining 1-R1-2-R2-3-protecting group-glycerol by introducing R2 group into 2-position of 1-R1-3-protecting group-glycerol; and carrying out the deprotection reaction and the acetylation reaction of 1-R1-2-R2-3-protecting group-glycerol at the same time. Wherein, R1 and R2 are fatty acid groups having 16 to 22 carbon atoms, and are different from each other; and the protecting group is trityl group or trialkylsilyl group.

    摘要翻译: 公开了以高效率和高产率区域选择性制备甘油衍生物的方法。 1-R1-2-R2-3-乙酰基 - 甘油衍生物的区域选择性制备方法包括以下步骤:通过将保护基引入1-R1的3-位获得1-R1-3保护基 - 甘油 甘油 通过将R2基团引入1-R1-3保护基 - 甘油的2-位获得1-R1-2-R2-3-保护基 - 甘油; 并同时进行1-R1-2-R2-3-保护基 - 甘油的去保护反应和乙酰化反应。 其中R1和R2是具有16-22个碳原子的脂肪酸基团,并且彼此不同; 保护基为三苯甲基或三烷基甲硅烷基。

    Preparation of glycerol derivatives ad intermediates therefor
    3.
    发明申请
    Preparation of glycerol derivatives ad intermediates therefor 有权
    甘油衍生物的制备及其中间体

    公开(公告)号:US20090253923A1

    公开(公告)日:2009-10-08

    申请号:US11989074

    申请日:2006-07-18

    IPC分类号: C07F9/02

    CPC分类号: C11C3/04

    摘要: Disclosed is a process for the regioselective preparation of glycerol derivative in a high efficiency and yield. The process for the regioselective preparation of 1-R1-2-R2-3-acetyl-glycerol derivative comprises the steps of: obtaining 1-R1-3-protecting group-glycerol by introducing a protecting group to 3-position of 1-R1-glycerol; obtaining 1-R1-2-R2-3-protecting group-glycerol by introducing R2 group into 2-position of 1-R1-3-protecting group-glycerol; and carrying out the deprotection reaction and the acetylation reaction of 1-R1-2-R2-3-protecting group-glycerol at the same time. Wherein, R1 and R2 are fatty acid groups having 16 to 22 carbon atoms, and are different from each other; and the protecting group is trityl group or trialkylsilyl group.

    摘要翻译: 公开了以高效率和高产率区域选择性制备甘油衍生物的方法。 1-R1-2-R2-3-乙酰基 - 甘油衍生物的区域选择性制备方法包括以下步骤:通过将保护基引入1-R1的3-位获得1-R1-3-保护基 - 甘油 甘油 通过将R2基团引入1-R1-3保护基 - 甘油的2-位获得1-R1-2-R2-3-保护基 - 甘油; 并同时进行1-R1-2-R2-3-保护基 - 甘油的去保护反应和乙酰化反应。 其中R1和R2是具有16-22个碳原子的脂肪酸基团,并且彼此不同; 保护基为三苯甲基或三烷基甲硅烷基。