公开(公告)号：US4602031A

公开(公告)日：1986-07-22

申请号：US741935

申请日：1985-06-06

申请人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

发明人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

IPC分类号： A61K31/415 ,  A61K31/445 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D521/00

CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/445 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： An antidepressive imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts.

摘要翻译： 一种下式的抗抑郁咪唑化合物：其中R1是低级烷基，R2是氢或低级烷基，R3，R4和R5是氢，低级烷基，三氟甲基，氨基，一或二低级烷基氨基，杂环氨基 ，卤素或 - - （其中R6是氢，低级烷基或低级烷基磺酰基，A是羰基或磺酰基，R7是低级烷基，卤代低级烷基，一或二低级烷基氨基，一或二 低级烷基，低级烷氧基或三氟甲基，苯基氨基或苯基氨基，具有卤素，低级烷基，低级烷氧基或三氟甲基）; 及其药学上可接受的酸加成盐。

公开(公告)号：US4402966A

公开(公告)日：1983-09-06

申请号：US252674

申请日：1981-04-09

申请人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

发明人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

IPC分类号： A61K31/415 ,  A61K31/445 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D521/00

CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/445 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： An imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts.The compounds are useful for treating patients suffering from depression.

摘要翻译： 下式的咪唑化合物：其中R1是低级烷基，R2是氢或低级烷基，R3，R4和R5是氢，低级烷基，三氟甲基，氨基，一或二低级烷基氨基，杂环氨基， 卤素或（其中R6是氢，低级烷基或低级烷基磺酰基，A是羰基或磺酰基，R7是低级烷基，卤代低级烷基，一或二低级烷基氨基，一或二低级烷基氨基烷基， 未取代的苯基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基，苯基氨基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基氨基）; 及其药学上可接受的酸加成盐。 该化合物可用于治疗患有抑郁症的患者。

公开(公告)号：US4533669A

公开(公告)日：1985-08-06

申请号：US469548

申请日：1983-02-25

申请人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

发明人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

IPC分类号： A61K31/415 ,  A61K31/445 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D521/00

CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/445 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： An anti-depressant imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts. These compounds are useful as agents for treating depression and depressive states.

摘要翻译： 一种下式的抗抑郁咪唑化合物：其中R1是低级烷基，R2是氢或低级烷基，R3，R4和R5是氢，低级烷基，三氟甲基，氨基，一或二低级烷基氨基， 杂环氨基，卤素或者其中R6是氢，低级烷基或低级烷基磺酰基，A是羰基或磺酰基，R7是低级烷基，卤代低级烷基，一或二低级烷基氨基，单 - 或二 - 低级烷基氨基烷基，未取代的苯基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基，苯基氨基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基氨基）。 及其药学上可接受的酸加成盐。 这些化合物可用作治疗抑郁和抑郁状态的药剂。

公开(公告)号：US4301169A

公开(公告)日：1981-11-17

申请号：US93469

申请日：1979-11-13

申请人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

发明人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

IPC分类号： A61K31/415 ,  A61K31/445 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D521/00

CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/445 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： An imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts.

摘要翻译： 下式的咪唑化合物：其中R1是低级烷基，R2是氢或低级烷基，R3，R4和R5是氢，低级烷基，三氟甲基，氨基，一或二低级烷基氨基，杂环氨基， 卤素或（其中R6是氢，低级烷基或低级烷基磺酰基，A是羰基或磺酰基，R7是低级烷基，卤代低级烷基，一或二低级烷基氨基，一或二低级烷基氨基烷基， 未取代的苯基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基，苯基氨基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基氨基）; 及其药学上可接受的酸加成盐。