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公开(公告)号：US20070167500A1
公开(公告)日：2007-07-19
申请号：US10562126
申请日：2004-06-25
IPC分类号： A61K31/426 , A61K31/195 , A61K31/18
CPC分类号： A61K45/06 , A61K31/195 , A61K31/277 , A61K2300/00
摘要： A preventive and/or a remedy for urinary tract diseases with symptoms such as urgency of urination, bladder pain, frequent urination or urine incontinence which comprises a combination of compound having antagonism to EP1 with another compound having antagonism to EP3 each selected from among prostaglandin E2 receptors. The combination of an EP1 antagonist with an EP3 antagonist is useful in preventing and/or treating urinary tract diseases with symptoms such as urgency of urination, bladder pain, frequent urination or urine incontinence, because of showing effect of improving urine retaining ability, improving bladder compliance, relieving hypertonic detrusor muscle and normalizing bladder perception.
摘要翻译： 具有诸如排尿紧急，膀胱疼痛，尿频排尿或尿失禁等症状的尿路疾病的预防和/或补救措施，其包括与具有拮抗作用的另一化合物的化合物的组合 至每个选自前列腺素E 2受体的EP 3。 EP 1拮抗剂与EP 3拮抗剂的组合可用于预防和/或治疗尿路疾病，其症状如排尿紧急，膀胱疼痛，尿频 或尿失禁，因为具有改善尿液保留能力，改善膀胱顺应性，缓解高渗性逼尿肌和正常化膀胱感觉的作用。
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公开(公告)号：US20100076038A1
公开(公告)日：2010-03-25
申请号：US12527340
申请日：2008-02-15
IPC分类号： A61K31/426 , A61P13/12
CPC分类号： C07D213/71 , A61K31/426 , A61K31/4402 , A61K45/06 , C07D277/20 , C07D277/36 , A61K2300/00
摘要： Disclosed is an EP1 antagonist, particularly a compound represented by the formula (I): wherein all symbols are as defined in the description, a salt thereof, a solvate thereof or a prodrug thereof. The compound, a salt thereof, a solvate thereof or a prodrug thereof is effective for prevention, treatment and/or symptom improvement of a dysuria (e.g., slow stream, splitting or spraying of the urine stream, intermittent stream, hesitancy, straining to void or terminal dribble).
摘要翻译： 公开了EP1拮抗剂，特别是由式（I）表示的化合物：其中所有符号如说明书中所定义，其盐，其溶剂化物或其前药。 该化合物，其盐，其溶剂合物或其前体药物对于排尿困难的预防，治疗和/或症状改善（例如，缓慢的流，尿流的分裂或喷雾，间歇流，犹豫，紧张到空隙中是有效的 或终点运球）。
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公开(公告)号：US09181187B2
公开(公告)日：2015-11-10
申请号：US12527340
申请日：2008-02-15
IPC分类号： A61K31/426 , C07D213/71 , A61K31/4402 , A61K45/06 , C07D277/20 , C07D277/36
CPC分类号： C07D213/71 , A61K31/426 , A61K31/4402 , A61K45/06 , C07D277/20 , C07D277/36 , A61K2300/00
摘要： Disclosed is an EP1 antagonist, particularly a compound represented by the formula (I): wherein all symbols are as defined in the description, a salt thereof, a solvate thereof or a prodrug thereof. The compound, a salt thereof, a solvate thereof or a prodrug thereof is effective for prevention, treatment and/or symptom improvement of a dysuria (e.g., slow stream, splitting or spraying of the urine stream, intermittent stream, hesitancy, straining to void or terminal dribble).
摘要翻译： 公开了EP1拮抗剂，特别是由式（I）表示的化合物：其中所有符号如说明书中所定义，其盐，其溶剂化物或其前药。 该化合物，其盐，其溶剂合物或其前体药物对于排尿困难的预防，治疗和/或症状改善（例如，缓慢的流，尿流的分裂或喷雾，间歇流，犹豫，紧张到空隙中是有效的 或终点运球）。
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