公开(公告)号：US09181187B2

公开(公告)日：2015-11-10

申请号：US12527340

申请日：2008-02-15

申请人： Takayuki Maruyama ,  Hiroki Okada ,  Takashi Konemura

发明人： Takayuki Maruyama ,  Hiroki Okada ,  Takashi Konemura

IPC分类号： A61K31/426 ,  C07D213/71 ,  A61K31/4402 ,  A61K45/06 ,  C07D277/20 ,  C07D277/36

CPC分类号： C07D213/71 ,  A61K31/426 ,  A61K31/4402 ,  A61K45/06 ,  C07D277/20 ,  C07D277/36 ,  A61K2300/00

摘要： Disclosed is an EP1 antagonist, particularly a compound represented by the formula (I): wherein all symbols are as defined in the description, a salt thereof, a solvate thereof or a prodrug thereof. The compound, a salt thereof, a solvate thereof or a prodrug thereof is effective for prevention, treatment and/or symptom improvement of a dysuria (e.g., slow stream, splitting or spraying of the urine stream, intermittent stream, hesitancy, straining to void or terminal dribble).

摘要翻译： 公开了EP1拮抗剂，特别是由式（I）表示的化合物：其中所有符号如说明书中所定义，其盐，其溶剂化物或其前药。 该化合物，其盐，其溶剂合物或其前体药物对于排尿困难的预防，治疗和/或症状改善（例如，缓慢的流，尿流的分裂或喷雾，间歇流，犹豫，紧张到空隙中是有效的 或终点运球）。

公开(公告)号：US20100076038A1

公开(公告)日：2010-03-25

申请号：US12527340

申请日：2008-02-15

申请人： Takayuki Maruyama ,  Hiroki Okada ,  Takashi Konemura

发明人： Takayuki Maruyama ,  Hiroki Okada ,  Takashi Konemura

IPC分类号： A61K31/426 ,  A61P13/12

CPC分类号： C07D213/71 ,  A61K31/426 ,  A61K31/4402 ,  A61K45/06 ,  C07D277/20 ,  C07D277/36 ,  A61K2300/00

摘要： Disclosed is an EP1 antagonist, particularly a compound represented by the formula (I): wherein all symbols are as defined in the description, a salt thereof, a solvate thereof or a prodrug thereof. The compound, a salt thereof, a solvate thereof or a prodrug thereof is effective for prevention, treatment and/or symptom improvement of a dysuria (e.g., slow stream, splitting or spraying of the urine stream, intermittent stream, hesitancy, straining to void or terminal dribble).

摘要翻译： 公开了EP1拮抗剂，特别是由式（I）表示的化合物：其中所有符号如说明书中所定义，其盐，其溶剂化物或其前药。 该化合物，其盐，其溶剂合物或其前体药物对于排尿困难的预防，治疗和/或症状改善（例如，缓慢的流，尿流的分裂或喷雾，间歇流，犹豫，紧张到空隙中是有效的 或终点运球）。

公开(公告)号：US20070167500A1

公开(公告)日：2007-07-19

申请号：US10562126

申请日：2004-06-25

申请人： Takayuki Maruyama ,  Michiyoshi Kobayashi ,  Shigeyuki Nonaka ,  Hiroki Okada ,  Takashi Konemura

发明人： Takayuki Maruyama ,  Michiyoshi Kobayashi ,  Shigeyuki Nonaka ,  Hiroki Okada ,  Takashi Konemura

IPC分类号： A61K31/426 ,  A61K31/195 ,  A61K31/18

CPC分类号： A61K45/06 ,  A61K31/195 ,  A61K31/277 ,  A61K2300/00

摘要： A preventive and/or a remedy for urinary tract diseases with symptoms such as urgency of urination, bladder pain, frequent urination or urine incontinence which comprises a combination of compound having antagonism to EP1 with another compound having antagonism to EP3 each selected from among prostaglandin E2 receptors. The combination of an EP1 antagonist with an EP3 antagonist is useful in preventing and/or treating urinary tract diseases with symptoms such as urgency of urination, bladder pain, frequent urination or urine incontinence, because of showing effect of improving urine retaining ability, improving bladder compliance, relieving hypertonic detrusor muscle and normalizing bladder perception.

摘要翻译： 具有诸如排尿紧急，膀胱疼痛，尿频排尿或尿失禁等症状的尿路疾病的预防和/或补救措施，其包括与具有拮抗作用的另一化合物的化合物的组合 至每个选自前列腺素E 2受体的EP 3。 EP 1拮抗剂与EP 3拮抗剂的组合可用于预防和/或治疗尿路疾病，其症状如排尿紧急，膀胱疼痛，尿频 或尿失禁，因为具有改善尿液保留能力，改善膀胱顺应性，缓解高渗性逼尿肌和正常化膀胱感觉的作用。

公开(公告)号：US20080021021A1

公开(公告)日：2008-01-24

申请号：US11660043

申请日：2005-08-09

申请人： Hiroki Okada ,  Takayuki Maruyama

发明人： Hiroki Okada ,  Takayuki Maruyama

IPC分类号： A61K31/535 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/5375 ,  A61P13/02 ,  A61K31/54 ,  A61K31/426 ,  A61K31/433 ,  A61K31/495 ,  A61K31/505

CPC分类号： A61K9/2054 ,  A61K31/5575 ,  A61K31/559 ,  A61K45/06 ,  A61K2300/00

摘要： (1) A preventive and/or a remedy for lower urinary tract diseases such as inflammation in the lower urinary tract, cystitis (interstitial cystitis, etc.) and urethritis; (2) an agent for improving bladder compliance and/or bladder capacity; and (3) an agent for protecting bladder mucosa and/or bladder epithelial cells and/or promoting the regeneration thereof; each containing an EP4 agonist. An EP4 agonist is useful in ameliorating symptoms of lower urinary tract diseases such as (1) frequent urination, (2) urgency of urination, (3) pain in the reproductive organs and/or lower urinary tract (for example, bladder pain, urinary tract pain, vulvar pain, vaginal pain, scrotal pain, perineal pain, pelvic pain, etc.) and/or (4) discomfort in the reproductive organs and/or lower urinary tract. Among all, a selective EP4 agonist is useful as a preventive and/or remedy for lower urinary tract diseases having no side effect.

摘要翻译： （1）下泌尿道疾病如下泌尿道炎症，膀胱炎（间质性膀胱炎等）和尿道炎的预防和/或补救措施; （2）改善膀胱依从性和/或膀胱容量的药剂; 和（3）用于保护膀胱粘膜和/或膀胱上皮细胞和/或促进其再生的药剂; 每个含有EP 4激动剂。 EP 4激动剂可用于改善下尿路疾病的症状，例如（1）尿频，（2）排尿紧急，（3）生殖器官和/或下泌尿道疼痛 （例如，膀胱疼痛，尿路疼痛，外阴疼痛，阴道疼痛，阴囊疼痛，会阴疼痛，骨盆疼痛等）和/或（4）生殖器官和/或下尿路中的不适。 其中，选择性EP 4激动剂可用作不具有副作用的下尿路疾病的预防和/或补救措施。

公开(公告)号：US07858610B2

公开(公告)日：2010-12-28

申请号：US11660043

申请日：2005-08-09

申请人： Hiroki Okada ,  Takayuki Maruyama

发明人： Hiroki Okada ,  Takayuki Maruyama

IPC分类号： A61K31/54 ,  A61K31/535

CPC分类号： A61K9/2054 ,  A61K31/5575 ,  A61K31/559 ,  A61K45/06 ,  A61K2300/00

摘要： (1) A preventive and/or a remedy for lower urinary tract diseases such as inflammation in the lower urinary tract, cystitis (interstitial cystitis, etc.) and urethritis; (2) an agent for improving bladder compliance and/or bladder capacity; and (3) an agent for protecting bladder mucosa and/or bladder epithelial cells and/or promoting the regeneration thereof; each containing an EP4 agonist.An EP4 agonist is useful in ameliorating symptoms of lower urinary tract diseases such as (1) frequent urination, (2) urgency of urination, (3) pain in the reproductive organs and/or lower urinary tract (for example, bladder pain, urinary tract pain, vulvar pain, vaginal pain, scrotal pain, perineal pain, pelvic pain, etc.) and/or (4) discomfort in the reproductive organs and/or lower urinary tract. Among all, a selective EP4 agonist is useful as a preventive and/or remedy for lower urinary tract diseases having no side effect.

摘要翻译： （1）下泌尿道疾病如下泌尿道炎症，膀胱炎（间质性膀胱炎等）和尿道炎的预防和/或补救措施; （2）改善膀胱依从性和/或膀胱容量的药剂; 和（3）用于保护膀胱粘膜和/或膀胱上皮细胞和/或促进其再生的药剂; 每个含有EP4激动剂。 EP4激动剂可用于改善下尿路疾病的症状，例如（1）尿频，（2）排尿紧急，（3）生殖器官和/或下尿路疼痛（例如膀胱疼痛，尿液 肠痛，外阴疼痛，阴道疼痛，阴囊疼痛，会阴疼痛，盆腔疼痛等）和/或（4）生殖器官和/或下泌尿道的不适。 其中，选择性EP4激动剂可用作没有副作用的下尿路疾病的预防和/或治疗。

公开(公告)号：US09709933B2

公开(公告)日：2017-07-18

申请号：US15059893

申请日：2016-03-03

申请人： Takashi Hayashi ,  Akira Yashiro ,  Kenji Sueyoshi ,  Hiroki Okada

发明人： Takashi Hayashi ,  Akira Yashiro ,  Kenji Sueyoshi ,  Hiroki Okada

IPC分类号： G03G15/20 ,  G03G15/00

CPC分类号： G03G15/2039 ,  G03G15/5004 ,  G03G15/80

摘要： A heating device includes: a heater; and a power distribution controller. The heater heats a predetermined heating target. The power distribution controller controls supply of AC power to the heater. The power distribution controller performs power distribution to the heater in units of AC half wave, and controls the power supply to the heater in accordance with power distribution control patterns respectively corresponding to a first time period as a power distribution start period, a third time period as a power distribution stop period, and a second time period between the first time period and the third time period.

公开(公告)号：US20130292156A1

公开(公告)日：2013-11-07

申请号：US13978313

申请日：2011-12-26

申请人： Hiroki Okada ,  Masayuki Sato ,  Toshimitsu Kamiya

发明人： Hiroki Okada ,  Masayuki Sato ,  Toshimitsu Kamiya

IPC分类号： H01B5/02

CPC分类号： H01B5/02 ,  H01R25/14 ,  H01R43/16 ,  H02B1/20

摘要： A bus bar includes a body having at least one bent portion and a plate-shaped or bar-like terminal located on at least one end of the body and formed of a material identical with a material of the body integrally with the body in a seamless manner. The terminal has a higher hardness than the bent portion.

摘要翻译： 汇流条包括具有至少一个弯曲部分的主体和位于主体的至少一个端部上的板状或棒状端子，并且由与主体的材料相同的材料形成为与主体一体的无缝 方式。 端子具有比弯曲部更高的硬度。

公开(公告)号：US08443552B2

公开(公告)日：2013-05-21

申请号：US12515140

申请日：2007-11-19

申请人： Kouji Kinoshita ,  Kazuhisa Chiba ,  Yukihito Suzuki ,  Hiroki Okada

发明人： Kouji Kinoshita ,  Kazuhisa Chiba ,  Yukihito Suzuki ,  Hiroki Okada

IPC分类号： B60J5/04

CPC分类号： B60J5/0426 ,  B60J5/045 ,  E05B85/12

摘要： A vehicle has a mounting structure for mounting a door guard bar. An insertion hole is formed in an upper portion of a trim pad, and a lever-handle accommodating hole is formed in a side portion of the trim pad below the insertion hole. An end portion of a lever handle is inserted into the lever-handle accommodating hole. A cover portion of a bezel is disposed on the inner side of the lever-handle accommodating hole, and covers a part of the lever-handle accommodating hole while exposing an operation portion of the lever handle to the inner side of the vehicle. A door guard bar is inserted into the insertion hole, and fixed to the inner door panel of the vehicle door. The cover portion of the bezel covers the portion of the door guard bar.

摘要翻译： 车辆具有用于安装门保护杆的安装结构。 在修剪衬垫的上部形成有插入孔，并且在插入孔下方的修剪衬垫的侧部形成有杠杆把手容纳孔。 杠杆手柄的端部插入杠杆柄手柄容纳孔中。 边框的盖部设置在杠杆把手容纳孔的内侧，并且在将手柄的操作部分暴露于车辆的内侧的同时覆盖杠杆把手容纳孔的一​​部分。 门锁杆插入插入孔中，并固定在车门的内门板上。 挡板的盖部分覆盖门保护条的一部分。

公开(公告)号：US08382170B2

公开(公告)日：2013-02-26

申请号：US12670594

申请日：2008-07-25

申请人： Kiyokazu Ieda ,  Eiji Mushiake ,  Kai Nakamura ,  Tomoo Kakegawa ,  Junzo Ooe ,  Hiroki Okada

发明人： Kiyokazu Ieda ,  Eiji Mushiake ,  Kai Nakamura ,  Tomoo Kakegawa ,  Junzo Ooe ,  Hiroki Okada

IPC分类号： E05B3/00 ,  E05B65/10

CPC分类号： B60R25/00 ,  E05B77/34 ,  E05B81/77 ,  E05B81/78 ,  E05B85/16 ,  Y10T16/458 ,  Y10T292/57

摘要： A door handle device for a vehicle is arranged in a door thereof. The door handle device includes a support member, door handle, lock detection electrode, and capacitance sensor. The door handle includes a first end, second end, pivot portion, and operation portion. A capacitance sensor detects issuance of a door lock command from a change in capacitance between an outer panel and lock detection electrode. The door handle includes a first handle case and second handle case covering the first handle case. The lock detection electrode is proximal to and faces an inner surface of at least one of an upper wall and lower wall of the second handle case. The lock detection includes an electrode end face facing the outer panel and formed to be non-planar.

摘要翻译： 用于车辆的门把手装置设置在其门中。 门把手装置包括支撑构件，门把手，锁定检测电极和电容传感器。 门把手包括第一端，第二端，枢转部分和操作部分。 电容式传感器根据外板和锁定检测电极之间的电容变化来检测门锁指令的发出。 门把手包括第一把手壳体和第二把手壳体，其覆盖第一把手壳体。 锁定检测电极靠近并面向第二把手壳体的上壁和下壁中的至少一个的内表面。 锁定检测包括面向外板并且形成为非平面的电极端面。

公开(公告)号：US08311473B2

公开(公告)日：2012-11-13

申请号：US12385746

申请日：2009-04-17

申请人： Takeshi Sasaki ,  Hiroki Okada ,  Junichi Iida ,  Shingo Matsushita

发明人： Takeshi Sasaki ,  Hiroki Okada ,  Junichi Iida ,  Shingo Matsushita

IPC分类号： G03G15/00 ,  B42B9/00

CPC分类号： G03G15/6544 ,  B26D5/16 ,  B26D5/32 ,  B26D7/015 ,  B26F1/02 ,  B42B5/103 ,  B42C1/12 ,  G03G2215/00818 ,  G03G2215/00822 ,  G03G2215/00936

摘要： A bookbinding device receives a sheet on which an image is formed from an image forming apparatus. In the bookbinding device, a punching unit performs a punching process on a sheet; an aligning unit aligns a plurality of sheets on which holes are punched; and a ring binding unit mounts, in the holes of the sheets aligned by the aligning unit, a ring-shaped binding tool to create a booklet. A prohibiting unit, if a sheet received from the image forming apparatus is a punched sheet having a hole thereon, causes the punching unit not to perform the punching process on the punched sheet.

摘要翻译： 装订装置从图像形成装置接收其上形成有图像的片材。 在装订装置中，冲压单元对片材进行冲压加工; 对齐单元排列穿孔的多个片材; 并且环形装订单元安装在由对准单元对准的片材的孔中，形成环形装订工具以创建小册子。 禁止单元，如果从图像形成装置接收到的片材是其上具有孔的冲压片材，则使冲孔单元不对冲压片材进行冲压加工。