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    Phenoxyacetic acid derivatives, pharmaceutical compositions and methods
    3.
    发明授权
    Phenoxyacetic acid derivatives, pharmaceutical compositions and methods 失效
    苯氧乙酸衍生物，药物组合物和方法

    公开(公告)号：US4948810A

    公开(公告)日：1990-08-14

    申请号：US306867

    申请日：1989-02-06

    申请人： Takeo Iwakuma ,  Takayuki Kawaguchi ,  Toyoharu Yamashita ,  Yasuhiko Sasaki ,  Tamotu Shimazaki

    发明人： Takeo Iwakuma ,  Takayuki Kawaguchi ,  Toyoharu Yamashita ,  Yasuhiko Sasaki ,  Tamotu Shimazaki

    IPC分类号： C07C311/17 ,  C07D333/34

    CPC分类号： C07C311/17 ,  C07D333/34

    摘要： Novel phenoxyacetic acid derivative of the formula: ##STR1## wherein R is a substituted or unsubstituted phenyl group, naphthyl group or a sulfur-containing 5-membered hetero-monocyclic group, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen atom, a lower alkyl group, a phenyl-lower alkyl group or phenyl group, R.sup.5 is hydrogen atom or a lower alkyl group, R.sup.6 is carboxyl group, a protected carboxyl group, hydroxy group or a di(lower alkyl)-amino group, Ring A is a substituted or unsubstituted phenylene group, m is 0 or 1 and n is an integer 0 to 5, provided that, when m is 0,(1) at least either one of R.sup.1 to R.sup.4 is or/are a phenyl-lower alkyl group or phenyl group,(2) at least either one of R.sup.1 to R.sup.4 is or/are a lower alkyl group, and R.sup.6 is hydroxy group, or(3) all of R.sup.1 to R.sup.4 are hydrogen atom, and Ring A is a substituted phenylene group,or a pharmaceutically acceptable salt thereof are disclosed. Said derivative (I) and a pharmaceutically acceptable salt thereof have a potent platelet aggregation-inhibiting activity.

    Indan derivatives used for treating thromboses or asthma
    5.
    发明授权
    Indan derivatives used for treating thromboses or asthma 失效
    用于治疗血栓形成或哮喘的Indan衍生物

    公开(公告)号：US5190975A

    公开(公告)日：1993-03-02

    申请号：US897412

    申请日：1992-06-12

    申请人： Takeo Iwakuma ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

    发明人： Takeo Iwakuma ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

    IPC分类号： C07C233/52 ,  C07C311/20 ,  C07C311/29 ,  C07D257/06 ,  C07D333/34 ,  C07D333/36

    CPC分类号： C07D333/36 ,  C07C233/52 ,  C07C311/20 ,  C07C311/29 ,  C07D257/06 ,  C07D333/34 ,  C07C2101/14 ,  C07C2102/08

    摘要： Method for the treatment or prophylaxis of thromboses or asthma in warm-blooded animal which comprises administering an effective amount of a compound having the formula: ##STR1## wherein R.sup.1 is phenyl group or phenyl group substituted by a member selected from the group consisting of C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, halogen atom, trifluoromethyl, and nitro, or naphthyl group, and R.sup.2 is hydroxymethyl or a group of the formula: ##STR2## wherein R.sup.3 is hydrogen atom or C.sub.1 -C.sub.5 alkyl and R.sup.4 is C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkoxycarbonyl-phenyl, carboxy-phenyl, C.sub.1 -C.sub.5 alkyl, or C.sub.1 -C.sub.5 alkyl having a substituent selected from C.sub.1 -C.sub.5 alkoxycarbonyl, carboxy, C.sub.2 -C.sub.6 alkoxycarbonyl-phenyl, carboxy-phenyl, C.sub.2 -C.sub.6 alkoxycarbonyl-(C.sub.3 -C.sub.6) cycloalkyl and carboxy-(C.sub.3 -C.sub.6) cycloalkyl, or a pharmaceutically acceptable salt thereof to said warm blooded animal.

    摘要翻译： 用于治疗或预防温血动物血栓形成或哮喘的方法，其包括给予有效量的具有下式的化合物：其中R 1是苯基或被选自C1的成员所取代的苯基 -C 5烷基，C 1 -C 5烷氧基，卤素原子，三氟甲基，硝基或萘基，R 2是羟甲基或下式的基团：其中R 3是氢原子或C 1 -C 5烷基， C 6环烷基，C 2 -C 6烷氧基羰基 - 苯基，羧基 - 苯基，C 1 -C 5烷基或具有选自C 1 -C 5烷氧基羰基，羧基，C 2 -C 6烷氧基羰基 - 苯基，羧基 - 苯基，C 2 -C 6 烷氧基羰基 - （C 3 -C 6）环烷基和羧基 - （C 3 -C 6）环烷基或其药学上可接受的盐。

    Phenoxyacetic acid derivatives and preparation thereof
    7.
    发明授权
    Phenoxyacetic acid derivatives and preparation thereof 失效
    苯氧乙酸衍生物及其制备

    公开(公告)号：US4866196A

    公开(公告)日：1989-09-12

    申请号：US141403

    申请日：1988-01-04

    申请人： Takeo Iwakuma ,  Takayuki Kawaguchi ,  Toyoharu Yamashita ,  Yasuhiko Sasaki ,  Tamotu Shimazaki

    发明人： Takeo Iwakuma ,  Takayuki Kawaguchi ,  Toyoharu Yamashita ,  Yasuhiko Sasaki ,  Tamotu Shimazaki

    IPC分类号： A61K31/18 ,  C07C311/15 ,  C07C311/19 ,  C07C311/25

    CPC分类号： C07C311/15

    摘要： Novel phenoxyacetic acid of the formula: ##STR1## wherein Ring A is phenylene group or a phenylene group having 1 to 2 substituent(s) selected from a lower alkyl group, a lower alkoxy group and a halogen atom; either one or two group(s) of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are a lower alkyl group, and the other groups are hydrogen atom; R.sup.5 is phenyl group or a phenyl group having 1 to 3 substituent(s) selected from a lower alkyl group, a halogen atom a lower alkoxy group and nitro group; and --COOR.sup.6 is carboxyl group or a protected carboxyl group, or a salt thereof are disclosed. Said derivative (I) and a salt thereof have a potent platelet aggregration-inhibiting activity.

    摘要翻译： 下式的新型苯氧基乙酸：其中环A是亚苯基或具有1至2个选自低级烷基，低级烷氧基和卤素原子的取代基的亚苯基; R1，R2，R3和R4中的一个或两个基团是低级烷基，其它基团是氢原子; R5是苯基或具有1〜3个选自低级烷基，卤素原子，低级烷氧基和硝基的取代基的苯基; -COOR6为羧基或被保护的羧基，或其盐。 所述衍生物（I）及其盐具有有效的血小板聚集抑制活性。