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    5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxycarbostyril derivatives
    7.
    发明授权
    5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxycarbostyril derivatives 失效
    5- {8-羟基-2-（取代的 - 氨基）{9乙基-8-羟基卡波特他尔衍生物

    公开(公告)号：US4022776A

    公开(公告)日：1977-05-10

    申请号：US536705

    申请日：1974-12-26

    申请人： Kazuyuki Nakagawa ,  Shiro Yoshizaki ,  Kaoru Tanimura ,  Shigeharu Tamada

    发明人： Kazuyuki Nakagawa ,  Shiro Yoshizaki ,  Kaoru Tanimura ,  Shigeharu Tamada

    IPC分类号： A61K31/47 ,  C07D215/20 ,  C07D215/22 ,  C07D215/24 ,  C07D215/26 ,  C07D215/32 ,  C07D401/06 ,  C07D413/06

    CPC分类号： C07C255/00 ,  A61K31/47 ,  C07D215/22 ,  C07D215/26 ,  C07D215/32 ,  Y10S514/826 ,  Y10S514/929

    摘要： 5-[Hydroxy-2-(substituted-amino)]ethyl-8-hydroxy-carbostyril derivatives represented by the formula (I) ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group containing a straight or branched chain alkyl moiety having 1 to 4 carbon atoms or a cycloalkyl group having 4 to 6 carbon atoms, or R.sup.1 and R.sup.2 may, when taken together with the nitrogen atom to which they are attached, form a 5 or 6-membered substituted or unsubstituted heterocyclic ring containing 1 or 2 nitrogen, oxygen or sulfur atoms as hetero atoms, the pharmaceutically acceptable acid addition salts thereof and a process for preparing the above compounds.

    摘要翻译： 由式（I）表示的5- [羟基-2-（取代 - 氨基）]乙基-8-羟基喹诺酮衍生物其中R1和R2可以相同或不同，各自表示 氢原子，具有1至4个碳原子的烷基，含有1至4个碳原子的直链或支链烷基部分或具有4至6个碳原子的环烷基的芳烷基，或者R 1和R 2可以一起 与它们所连接的氮原子形成5或6元取代或未取代的杂环，该杂环含有1或2个氮原子，氧原子或硫原子作为杂原子，其药学上可接受的酸加成盐及其制备方法 化合物。

    N,N'-bis-[(.beta.-hydroxy-.beta.-phenyl)-ethyl]-polymethylenediamines and salts thereof
    8.
    发明授权
    N,N'-bis-[(.beta.-hydroxy-.beta.-phenyl)-ethyl]-polymethylenediamines and salts thereof 失效
    N，N {40-双 - {8（{62-羟基 - {62-苯基） - 乙基{9-聚亚甲基二胺及其盐

    公开(公告)号：US4021485A

    公开(公告)日：1977-05-03

    申请号：US628819

    申请日：1975-11-04

    申请人： Kurt Schromm ,  Anton Mentrup ,  Ernst-Otto Renth ,  Werner Traunecker

    发明人： Kurt Schromm ,  Anton Mentrup ,  Ernst-Otto Renth ,  Werner Traunecker

    IPC分类号： C07C229/38 ,  C07C275/24 ,  C07D215/26 ,  C07D215/32 ,  C07C91/16

    CPC分类号： C07D215/26 ,  C07C229/38 ,  C07C275/24 ,  C07D215/32 ,  Y02P20/55

    摘要： Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen or methyl, m is 0 or an integer from 1 to 8, inclusive, andAr is ##STR2## WHERE R is hydrogen or acyl, andR.sub.2 is hydrogen or --OR, as defined above, ##STR3## WHERE R has the meanings defined above, andR.sub.3 is hydroxy-lower alkyl, --NH--CO--R.sub.4, --NH--SO.sub.2 --R.sub.5, --CH.sub.2 --NH--CO--R.sub.4, --CH.sub.2 --NH--SO.sub.2 --R.sub.5 or --CH.sub.2 --NH--CO--NH--R.sub.4, whereR.sub.4 is hydrogen or lower alkyl, andR.sub.5 is lower alkyl or di-lower alkyl-amino, ##STR4## WHERE R.sub.6 is hydrogen, amino or hydroxyl,X is chlorine or bromine, andY is hydrogen, chlorine or bromine or ##STR5## WHERE R has the meanings defined above, andA is a saturated or unsaturated 5- to 6-membered ring,And their non-toxic, pharmacologically acceptable acid addition salts; the compounds as well as their salts are useful as bronchospasmolytics, uterine spasmolytics, antipruritics and antiallergics.

    摘要翻译： 式（Ⅰ）化合物其中R 1为氢或甲基，M为0或整数1至8，包含和Ar为（a）R为氢或酰基，R 2为氢 或-OR，如上所定义，（b）其中R具有上述定义，并且R 3是羟基 - 低级烷基，-NH-CO-R 4，-NH-SO 2 -R 5，-CH 2 -NH-CO -R4，-CH2-NH-SO2-R5或-CH2-NH-CO-NH-R4，其中R4是氢或低级烷基，R5是低级烷基或二 - 低级烷基 - 氨基，（c） 其中R6是氢，氨基或羟基，X是氯或溴，Y是氢，氯或溴。（d）其中R具有上述定义，A是饱和或不饱和的5-至6- 及其非毒性，药理学上可接受的酸添加剂; 化合物作为其作为BRONCHOSPASMOLYTICS，UTERINE SPASMOLYTICS，ANTIPRITICS和ANTIALLERGICS的有用的化合物。

    2-Amino-1,4-dihydropyridine derivatives
    10.
    发明授权
    2-Amino-1,4-dihydropyridine derivatives 失效

    公开(公告)号：US3971790A

    公开(公告)日：1976-07-27

    申请号：US574347

    申请日：1975-05-05

    申请人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

    发明人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

    IPC分类号： C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D215/32

    CPC分类号： C07D401/04 ,  C07D405/04 ,  C07D409/04

    摘要： 2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives are further substituted by a carbonyl group in the 3-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and an amidine.CROSS REFERENCEThis is a division of Ser. No. 438,603 filed Feb. 1, 1974, now U.S. Pat. No. 3,929,798, which in turn is a division of Ser. No. 336,639 filed Feb. 28, 1973, now U.S. Pat. No. 3,867,393.