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公开(公告)号：US06228882B1
公开(公告)日：2001-05-08
申请号：US09397765
申请日：1999-09-15
IPC分类号： A61K31351
CPC分类号： C07D309/36 , A61K31/366 , C07C45/29 , C07C45/298 , C07C45/30 , C07C47/21 , C07C57/66 , C07D309/38 , C07F7/0812 , C07F7/1804
摘要： The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
摘要翻译： 本发明提供了用于制备myxopyronins和珊瑚绿素的收敛过程，其用作抗菌治疗剂。 本发明还提供了可用于制备pyronin抗生素的新物质组合物。
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公开(公告)号：US08770589B2
公开(公告)日：2014-07-08
申请号：US13532498
申请日：2012-06-25
申请人： Taiji Hashimoto , Tao Hu , Eiji Okumachi , Masanobu Ninomiya
发明人： Taiji Hashimoto , Tao Hu , Eiji Okumachi , Masanobu Ninomiya
IPC分类号： F16J15/34
CPC分类号： F16J15/40 , F16J15/3404 , F16J15/3484
摘要： A shaft-seal device for high-temperature fluid including a seal case (2) formed as a metallic cylindrical structure of a single unit and comprised of a main body portion (2a, 2b, 2c), first and second holding portions (2d, 2e), first and second partition portions (2f, 2h), a channel formation portion (2g) forming a minute annular channel (27) with the outer circumference surface of a rotary shaft (1), and an o-ring holding portion (2i). The seal case is installed in an apparatus housing (8) with first and second o-rings (2m, 2n) in between. The intra-seal case region (A1), in which sealing rings (31, 32, 41, 42, 51, 52) of mechanical seals (3, 4, 5) are provided, and the high-temperature fluid region, which is an intra-apparatus housing region (A), are partitioned by a cooling chamber (28) into and from which coolant (82) is supplied and discharged via feed/discharge coolant paths (80, 81).
摘要翻译： 一种用于高温流体的轴封装置，包括形成为单个单元的金属圆柱形结构并由主体部分（2a，2b，2c）构成的密封壳体（2），第一和第二保持部分（2d， 2e），第一和第二分隔部分（2f，2h），形成具有旋转轴（1）的外周表面的微小环形通道（27）的通道形成部分（2g）和O形环保持部分 2i）。 密封壳体安装在其间具有第一和第二O形环（2m，2n）的装置壳体（8）中。 密封壳体区域（A1），其中设置有机械密封件（3,4,5）的密封环（31,32,31,42,51,52）和高温流体区域 装置内的壳体区域（A）被冷却室（28）分隔开并从其中供应并通过供给/排出冷却剂通道（80,81）排出冷却剂（82）。
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6.发明授权公开(公告)号：US08304413B2
公开(公告)日：2012-11-06
申请号：US12477715
申请日：2009-06-03
申请人： Karl Kossen , Scott D. Seiwert , Vladimir Serebryany , Donald Ruhrmund , Leonid Beigelman , Luca Francesco Mario Raveglia , Stefania Vallese , Ivana Bianchi , Tao Hu
发明人： Karl Kossen , Scott D. Seiwert , Vladimir Serebryany , Donald Ruhrmund , Leonid Beigelman , Luca Francesco Mario Raveglia , Stefania Vallese , Ivana Bianchi , Tao Hu
IPC分类号： A61K31/50 , A61K31/497 , A61K31/437 , A61K31/44
CPC分类号： C07D213/63 , C07D213/22 , C07D213/64 , C07D213/69 , C07D213/71 , C07D213/85 , C07D237/14 , C07D239/36 , C07D239/54 , C07D241/18 , C07D251/10 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
摘要翻译： 公开了用于治疗炎症和纤维化疾病的化合物和方法，包括用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物表现出低的抑制p38MAPK的能力; 并且其中所述接触以对所述化合物抑制p38MAPK的抑制浓度低的SAPK调节浓度进行。 还公开了吡非尼酮的衍生物和类似物，其可用于调节应激活化蛋白激酶（SAPK）系统。
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公开(公告)号：US20090258850A1
公开(公告)日：2009-10-15
申请号：US12196271
申请日：2008-08-21
申请人： James M. Frincke , Steven K. White , Yu Ge , Weicheng Liaw , Tao Hu
发明人： James M. Frincke , Steven K. White , Yu Ge , Weicheng Liaw , Tao Hu
IPC分类号： A61K31/5685
CPC分类号： A61K9/10 , A61K9/0019
摘要： The invention relates to pharmaceutically acceptable formulations comprising an active pharmaceutical ingredient such as androst-5-ene-3β,17β-diol, androst-5-ene-3β,7β,17β-triol or derivatives of either of these compounds and an air oxidizable excipient that have been stabilized with respect to efficacy. Use of the efficacy-stabilized formulations to treat a number of conditions or symptoms thereof, such as a symptom associated with exposure to radiation is described.
摘要翻译： 本发明涉及包含活性药物成分如雄甾-5-烯-3β，17β-二醇，雄甾-5-烯-3β，7beta，17β-三醇或这些化合物的衍生物的药学上可接受的制剂和可氧化的 相关功效已被稳定的赋形剂。 描述了使用功效稳定的制剂来治疗许多病症或症状，例如与暴露于辐射相关的症状。
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9.发明申请TELECOMMUNICATION AND COMPUTING PLATFORMS WITH SERIAL PACKET SWITCHED INTEGRATED MEMORY ACCESS TECHNOLOGY 有权具有串行分组交换式集成存储器访问技术的电信和计算机平台公开(公告)号：US20080052436A1
公开(公告)日：2008-02-28
申请号：US11828329
申请日：2007-07-25
申请人： Viswa Sharma , Barton Stuck , Ching-Tao Hu , Yi-chang Chou , William Chu
发明人： Viswa Sharma , Barton Stuck , Ching-Tao Hu , Yi-chang Chou , William Chu
IPC分类号： G06F13/00
CPC分类号： G06F13/4063
摘要： A computing and communication architecture utilizes a serial protocol based switched fabric among circuit cards housed in packaging arrangement. In one embodiment, each circuit card connected to the serial protocol based switched fabric in the packaging arrangement is provided with a protocol processor that enables all of the circuit cards to efficiently provide packet-based serial self-clocked communications at line speed. As a result, it is not necessary to arrange the circuit cards in a hierarchical manner in order to address the problems of switch blocking and related traffic congestion issues that would otherwise limit the implementation of the serial protocol based backplane arrangement for housing circuit cards.
摘要翻译： 计算和通信架构在包装布置中的电路卡之间使用基于串行协议的交换结构。 在一个实施例中，在封装装置中连接到基于串行协议的交换结构的每个电路卡设置有协议处理器，其使得所有电路卡能够以线速度有效地提供基于分组的串行自定时通信。 结果，不需要以分层方式布置电路卡，以便解决交换机阻塞和相关业务拥塞问题的问题，否则将限制基于串行协议的背板布置用于容纳电路卡的实现。
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公开(公告)号：US06396939B1
公开(公告)日：2002-05-28
申请号：US09321489
申请日：1999-05-27
申请人： Tao Hu , Francoys Labonté
发明人： Tao Hu , Francoys Labonté
IPC分类号： G06K900
CPC分类号： G06T7/0012 , G06T5/002 , G06T5/20 , G06T7/11 , G06T2207/10081 , G06T2207/10088 , G06T2207/30008
摘要： A segmentation method and system for medical images of a structure, including at least one substructure are described herein. Examples of such structure and substructures are a vertebra and its spinal canal or a sacrum with its two foramens. The method consists of first providing a plurality of digital images representing consecutive slices of the structure. The set of images is then divided into groups for which initial substructures center position are estimated. Using this information, the pixels corresponding to each substructure and common to all the images in the group are determined. Iterations are performed between these two last steps until the best candidates are obtained. The method consists then in estimating the substructures center position in each image of the group. After the substructures have been identified in each image, the images are then processed to remove noise in the substructures, in the rest of the structure and outside the structure.
摘要翻译： 本文描述了包括至少一个子结构的结构的医学图像的分割方法和系统。 这种结构和子结构的实例是椎骨及其椎管或具有其两个孔的骶骨。 该方法包括首先提供表示结构的连续切片的多个数字图像。 然后将该组图像划分成对其初始子结构中心位置进行估计的组。 使用该信息，确定与每个子结构相对应的像素并且对于该组中的所有图像共同的像素。 在这两个最后的步骤之间进行迭代，直到获得最佳候选者。 该方法包括估计组中每个图像中的子结构中心位置。 在每个图像中已经识别到子结构之后，然后处理图像以去除子结构中的噪声，在结构的其余部分和结构外部。
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