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1.发明授权公开(公告)号：US07368438B2
公开(公告)日：2008-05-06
申请号：US10971766
申请日：2004-10-21
申请人： Robert Plourde, Jr. , Sammy R. Shaver , José L. Boyer , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova , Chi Tu
发明人： Robert Plourde, Jr. , Sammy R. Shaver , José L. Boyer , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova , Chi Tu
CPC分类号： C07D471/04 , A61K31/00 , A61K31/519 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , C07D493/04 , C07D519/00 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formula I and III-XI, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds according to Formula I and III-XI.
摘要翻译： 本发明涉及一种预防或治疗血小板聚集相关疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XI的化合物，或其盐，水合物和溶剂合物。 本发明还提供了根据式I和III-XI的新化合物。
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2.发明授权公开(公告)号：US07335648B2
公开(公告)日：2008-02-26
申请号：US11124619
申请日：2005-05-05
申请人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
发明人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括对可用于本发明的化合物施用包括通式I和III-XII的化合物，或其盐，水合物和溶剂化物。 本发明还提供式I和III-XII的新型化合物。
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公开(公告)号：US20100197913A1
公开(公告)日：2010-08-05
申请号：US12552465
申请日：2009-09-02
申请人： Robert Plourde, JR. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
发明人： Robert Plourde, JR. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
IPC分类号： C07D473/34
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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公开(公告)号：US07943760B2
公开(公告)日：2011-05-17
申请号：US12552465
申请日：2009-09-02
申请人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
发明人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和III-XII的化合物，或其盐，水合物和溶剂合物。 本发明还提供式I和III-XII的新型化合物。
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5.发明授权公开(公告)号：US07592445B2
公开(公告)日：2009-09-22
申请号：US11969539
申请日：2008-01-04
申请人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
发明人： Robert Plourde, Jr. , Sammy R. Shaver , James G. Douglass, III , Paul S. Watson , José L. Boyer , Chi Tu , Melwyn A. Abreo , Lorenzo J. Alfaro-Lopez , Yangbo Feng , Daniel F. Harvey , Tatyana V. Khasonova
CPC分类号： C07D519/00 , A61F2250/0067 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/7076 , A61K31/727 , A61K45/06 , A61K2300/00
摘要： This invention is directed to compounds of Formulae III and V, useful for treating diseases or conditions associated with platelet aggregation.
摘要翻译： 本发明涉及式III和V的化合物，其可用于治疗与血小板聚集有关的疾病或病症。
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