公开(公告)号：US20070259949A1

公开(公告)日：2007-11-08

申请号：US11831886

申请日：2007-07-31

申请人： Yu-Hung Chiu ,  Tessie Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

发明人： Yu-Hung Chiu ,  Tessie Che ,  Alex Romero ,  Yoshi Ichikawa ,  Youe-Kong Shue

IPC分类号： A61K31/335 ,  A61P31/04 ,  C07D313/00

CPC分类号： C07H17/08 ,  C07D407/14

摘要： The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.

摘要翻译： 本发明涉及显示广谱抗生素活性的化合物的新形式，特别是结晶多晶形式和这种化合物的无定形形式，包含这种结晶多晶形式的组合物和这种化合物的无定形形式，其制备和使用方法。 本发明的化合物和组合物可用于制药工业，例如用于治疗或预防与使用抗生素，化学疗法或抗病毒疗法相关的疾病或病症，包括但不限于结肠炎，例如 ，假膜性结肠炎; 抗生素相关性腹泻; 和艰难梭菌（“艰难梭菌”），产气荚膜梭菌（“产气荚膜梭菌”），葡萄球菌属，例如耐甲氧西林葡萄球菌或包括耐万古霉素肠球菌在内的肠球菌引起的感染。