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公开(公告)号:US5039669A
公开(公告)日:1991-08-13
申请号:US566145
申请日:1990-08-10
申请人: Yasuo Isomura , Makoto Takeuchi , Tetshshi Abe
发明人: Yasuo Isomura , Makoto Takeuchi , Tetshshi Abe
IPC分类号: C07F9/6561
CPC分类号: C07F9/6561
摘要: A novel heterocyclic bisphosphonic acid derivatives represented by the following general formula (I): ##STR1## in which .circle.Het means one of the following (A) and (B): ##STR2## wherein a dotted line in (A) means that two adjacent atoms are bonded by a single bond or a double bond, ##STR3## wherein R.sup.6 and R.sup.7 may be the same or different, each represents a hydrogen atom, a lower alkyl group, a halogen atom or a hydroxyl group,R.sup.1 represents a hydrogen atom or a hydroxyl group,R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different, each represents a hydrogen atom or a lower alkyl group,"n" is 0 or 1,provided that "n" is 1 when the ring .circle.Het means (A), and "R.sup.1 " is a hydroxyl group when the ring .dotthalfcircle.Het means (B), or pharmaceutically acceptable salts thereof and bone resorption inhibitors containing the compound as an active ingredient.