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    FACTOR XIII IMMUNOASSAY
    1.
    发明申请
    FACTOR XIII IMMUNOASSAY 有权

    公开(公告)号：US20210405073A1

    公开(公告)日：2021-12-30

    申请号：US17290369

    申请日：2019-10-30

    申请人： The Research Institute at Nationwide Children's Hospital

    发明人： Bryce A. Kerlin ,  Michael A. Durda ,  Amanda P. Waller ,  Katelyn J. Wolfgang

    IPC分类号： G01N33/86 ,  G01N33/543

    摘要： A method of detecting factor XIII activity in a biological sample is described. The method includes the steps of immobilizing or having obtained a capture antibody on a solid support, wherein the capture antibody comprises an antibody or antibody fragment that specifically binds to fibrinogen; incubating the biological sample with the capture antibody; contacting the immobilized capture antibody with α-thrombin, calcium, and α2-antiplasmin (AP); contacting the immobilized capture antibody with a detection antibody or antibody fragment that specifically binds to α2-AP, wherein the detection antibody or antibody fragment includes a detection label; and determining that factor XIII activity is present if the detection label is detected. The method can be used to diagnose a subject having factor XIII deficiency, or to monitor factor XIII levels in a subject undergoing factor XIII replacement therapy.

    COMPREHENSIVE ANALYSIS PIPELINE FOR DISCOVERY OF HUMAN GENETIC VARIATION
    6.
    发明申请
    COMPREHENSIVE ANALYSIS PIPELINE FOR DISCOVERY OF HUMAN GENETIC VARIATION 审中-公开

    公开(公告)号：US20170220732A1

    公开(公告)日：2017-08-03

    申请号：US15412503

    申请日：2017-01-23

    申请人： THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL

    发明人： Peter WHITE ,  David Lawrence NEWSOM ,  Yangyiu HU

    IPC分类号： G06F19/20 ,  C12Q1/68 ,  G06F19/22 ,  G06F19/28

    CPC分类号： G16B25/00 ,  C12Q1/6874 ,  G16B15/00 ,  G16B20/00 ,  G16B30/00 ,  G16B50/00

    摘要： Systems and methods for analyzing genetic sequence data involve: (a) obtaining, by a computer system, genetic sequencing data pertaining to a subject; (b) splitting the genetic sequencing data into a plurality of segments; (c) processing the genetic sequencing data such that intra-segment reads, read pairs with both mates mapped to the same data set, are saved to a respective plurality of individual binary alignment map (BAM) files corresponding to that respective segment; (d) processing the genetic sequencing data such that inter-segment reads, read pairs with both mates mapped to different segments, are saved into at least a second BAM file; and (e) processing at least the first plurality of BAM files along parallel processing paths. The plurality of segments may correspond to any given number of genomic subregions and may be selected based upon the number of processing cores used in the parallel processing.

    ANTICANCER ROCAGLAMIDE DERIVATIVES
    10.
    发明申请
    ANTICANCER ROCAGLAMIDE DERIVATIVES 有权

    公开(公告)号：US20210346337A1

    公开(公告)日：2021-11-11

    申请号：US17284112

    申请日：2019-10-09

    申请人： The Research institute at Nationwide Children's Hospital

    发明人： Long-Sheng Chang ,  A. Douglas Kinghorn

    IPC分类号： A61K31/343 ,  A61K9/00 ,  A61P35/00

    摘要： A method of treating nervous system cancer or soft-tissue sarcoma in a subject is described. The method includes administering a therapeutically effective amount of a compound according to formula I to a subject in need thereof: wherein R1 is selected from the group consisting of —OH, —OAc, —OCHO, ═O, and ═NOH; R2 is selected from the group consisting of —CON(CH3)2, —CONHCH3, —CONH2, —COOCH3, —COOH, and —H, R3 is selected from the group consisting of —H, —OH, and —OCH3, and R4 is selected from the group consisting of —OH, —OCH3, —OCH2CH3.