Process for the preparation of 1-amino-1-methyl-3(4)-aminomethyl
cyclohexane
    1.
    发明授权
    Process for the preparation of 1-amino-1-methyl-3(4)-aminomethyl cyclohexane 失效
    1-氨基-1-甲基-3(4) - 氨基甲基环己烷的制备方法

    公开(公告)号:US5900507A

    公开(公告)日:1999-05-04

    申请号:US38331

    申请日:1998-03-11

    摘要: The present invention relates to a process for the preparation of 1-amino-1-methyl-3(4)-aminomethyl cyclohexane (AMCA) bya) catalytically hydrogenating 1-formamido-1-methyl-3(4)-cyano cyclohexane (FMC) in a first reaction stage to form 1-formamido-1-methyl-3(4)-aminomethyl cyclohexane (FMA), 1-amino-1-methyl-3(4)-formamidomethyl cyclohexane (AMF), 1-formamido-1-methyl-3(4)-formamidomethyl cyclohexane (FMF) and/or AMCA, andb) reacting FMA, AMF and/or FMF in a second reaction stage with an alkaline compound to from AMCA and a formic acid derivative, andc) separating the reaction mixture obtained in step b) into components by fractional distillation and/or by crystallization and filtration.The present invention is also relates to carrying the hydrogenation reaction of step a) in the presence of a formulating agent to form 1-formamido-1-methyl-3(4)-formamidomethyl cyclohexane (FMF).Finally, the present invention relates to the intermediate products 1-formamido-1-methyl-3(4)-aminomethyl cyclohexane (FMA) and 1-formamido-1-methyl-3(4)-formamidomethyl cyclohexane (FMF).

    摘要翻译: 本发明涉及通过以下方法制备1-氨基-1-甲基-3(4) - 氨基甲基环己烷(AMCA)的方法:a)催化氢化1-甲酰氨基-1-甲基-3(4) - 氰基环己烷 FMA),1-氨基-1-甲基-3(4) - 氨基甲基环己烷(FMA),1-氨基-1-甲基-3(4) - 甲酰胺基甲基环己烷(AMF),1-甲酰胺 使甲基-3(4) - 甲酰胺基甲基环己烷(FMF)和/或AMCA,和b)使第二反应阶段中的FMA,AMF和/或FMF与碱性化合物与AMCA和甲酸衍生物反应,以及 c)通过分步和/或通过结晶和过滤将步骤b)中获得的反应混合物分离成组分。 本发明还涉及在配制剂的存在下进行步骤a)的氢化反应以形成1-甲酰氨基-1-甲基-3(4) - 甲酰胺基甲基环己烷(FMF)。 最后,本发明涉及中间产物1-甲酰氨基-1-甲基-3(4) - 氨基甲基环己烷(FMA)和1-甲酰氨基-1-甲基-3(4) - 甲酰胺基甲基环己烷(FMF)。

    Process for the production of
1-amino-1-methyl-3(4)-aminomethylcyclohexane
    2.
    发明授权
    Process for the production of 1-amino-1-methyl-3(4)-aminomethylcyclohexane 失效
    1-氨基-1-甲基-3(4) - 氨基甲基环己烷的制备方法

    公开(公告)号:US5905170A

    公开(公告)日:1999-05-18

    申请号:US38636

    申请日:1998-03-11

    摘要: The present invention relates to a process for the production of 1-amino-1-methyl-3(4)-aminomethylcyclohexane bya) simultaneously reacting 4(5)-aminomethyl-1-methylcyclohexene (CMA), hydrocyanic acid and aqueous sulphuric acid at temperatures of 60.degree. C. to 120.degree. C., preferably 80.degree. C. to 120.degree. C. to form 1-formamido-1-methyl-3(4)-aminomethylcyclohexane (FMA) in a first stage,b) adding water and hydrolyzing 1-formamido-1-methyl-3 (4)-aminomethylcyclohexane (FMA) and unreacted hydrocyanic acid in a second stage andc) adding a base and isolating 1-amino-1-methyl-3 (4)-aminomethylcyclohexane (AMCA) by extraction from the reaction mixture obtained in the second stage of the reaction, optionally after removing of formic acid.

    摘要翻译: 本发明涉及通过以下方法生产1-氨基-1-甲基-3(4) - 氨基甲基环己烷的方法:a)同时使4(5) - 氨基甲基-1-甲基环己烯(CMA),氢氰酸和硫酸水溶液 在60℃至120℃,优选80℃至120℃的温度下,在第一阶段中形成1-甲酰胺基-1-甲基-3(4) - 氨基甲基环己烷(FMA),b)加入 水并在第二阶段水解1-甲酰氨基-1-甲基-3(4) - 氨基甲基环己烷(FMA)和未反应的氢氰酸,和c)加入碱并分离1-氨基-1-甲基-3(4) - 氨基甲基环己烷 (AMCA),通过从反应第二阶段获得的反应混合物中提取,任选地在除去甲酸之后。