公开(公告)号：US08329937B2

公开(公告)日：2012-12-11

申请号：US12682249

申请日：2009-06-18

申请人： Pietro Allegrini ,  Tiziano Scubla ,  Nicoletta Toniutti ,  Romano Rivolta ,  Thierry Delahaique

发明人： Pietro Allegrini ,  Tiziano Scubla ,  Nicoletta Toniutti ,  Romano Rivolta ,  Thierry Delahaique

IPC分类号： C07C203/04

CPC分类号： C07C203/04 ,  C07C201/02

摘要： The present invention relates to a method for purifying naproxcinod comprising the steps of: a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two phases dispersion under stirring to a temperature ranging from −20° C. to 10° C. c) optionally seeding the solution with crystals of naproxcinod d) stirring, by maintaining the temperature in the range from −40° C. to 10° C. e) collecting the formed solid by maintaining the temperature under 15° C. A further object of the invention is a crystalline form of naproxcinod.

摘要翻译： 本发明涉及一种纯化萘普生的方法，包括以下步骤：a）在溶剂中将含有高于90重量％的萘普生的混合物溶解或分散; b）在搅拌下将溶液或两相分散体冷却至-20℃至10℃的温度。c）任选地用萘普生染料的晶体接种该溶液d）搅拌，通过将温度保持在-40℃ ℃至10℃。e）通过将温度保持在15℃下收集形成的固体。本发明的另一个目的是萘普生的结晶形式。

公开(公告)号：US20100256411A1

公开(公告)日：2010-10-07

申请号：US12682249

申请日：2009-06-18

申请人： Pietro Allegrini ,  Tiziano Scubla ,  Nicoletta Toniutti ,  Romano Rivolta ,  Thierry Delahaique

发明人： Pietro Allegrini ,  Tiziano Scubla ,  Nicoletta Toniutti ,  Romano Rivolta ,  Thierry Delahaique

IPC分类号： C07C203/04

CPC分类号： C07C203/04 ,  C07C201/02

摘要： The present invention relates to a method for purifying naproxcinod comprising the steps of: a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two phases dispersion under stirring to a temperature ranging from −20° C. to 10° C. c) optionally seeding the solution with crystals of naproxcinod d) stirring, by maintaining the temperature in the range from −40° C. to 10° C. e) collecting the formed solid by maintaining the temperature under 15° C. A further object of the invention is a crystalline form of naproxcinod.

摘要翻译： 本发明涉及一种纯化萘普生的方法，包括以下步骤：a）在溶剂中将含有高于90重量％的萘普生的混合物溶解或分散; b）在搅拌下将溶液或两相分散体冷却至-20℃至10℃的温度。c）任选地用萘普生染料的晶体接种该溶液d）搅拌，通过将温度保持在-40℃ ℃至10℃。e）通过将温度保持在15℃下收集形成的固体。本发明的另一个目的是萘普生的结晶形式。