公开(公告)号：US20080070860A1

公开(公告)日：2008-03-20

申请号：US11814519

申请日：2006-02-03

Applicant: Floyd Snyder ,  Thomas Back

Inventor： Floyd Snyder ,  Thomas Back

IPC: A61K31/7076 ,  A61P33/02 ,  C07H19/16

CPC classification number: C07H19/167 ,  C07H19/173

Abstract: The present invention is directed to purine nucleoside analogs of the general Formula (I), or tautomers thereof, physiologically acceptable salts, solvents and physiologically functional derivatives thereof, and pharmaceutical compositions comprising such compounds, salts and derivatives, which are useful as anti-bacterial and anti-protozoan agents. The invention is also directed to methods for treating a bacterial or protozoan infection in a mammal and use of the compounds for inhibiting the growth of a bacteria or protozoa.

Abstract translation: 本发明涉及通式（I）的嘌呤核苷类似物或其互变异构体，其生理学上可接受的盐，溶剂和生理功能衍生物，以及包含这些化合物，盐和衍生物的药物组合物，其可用作抗细菌剂 和抗原生动物。 本发明还涉及用于治疗哺乳动物细菌或原生动物感染的方法以及用于抑制细菌或原生动物生长的化合物。

公开(公告)号：US20070123501A1

公开(公告)日：2007-05-31

申请号：US11543994

申请日：2006-10-06

Applicant: Dusan Kuzma ,  Thomas Back ,  Noah Berkowitz

Inventor： Dusan Kuzma ,  Thomas Back ,  Noah Berkowitz

IPC: C07D293/10 ,  C07D345/00 ,  A61K31/33

CPC classification number: C07D345/00 ,  C07D329/00 ,  C07D517/10

Abstract: This invention relates to novel organoselenium and tellurium compounds, processes of producing the same and methods of use thereof. The compounds function as mimetics for the catalyst selenoenzyme glutathione peroxidase, which protects cells from oxidative stress.

Abstract translation: 本发明涉及新型有机硒和碲化合物，其制备方法及其使用方法。 该化合物作为催化剂硒酶酶谷胱甘肽过氧化物酶的模拟物，其保护细胞免受氧化应激。

公开(公告)号：US20070254849A1

公开(公告)日：2007-11-01

申请号：US11728834

申请日：2007-03-26

Applicant: S.R. Chen ,  Thomas Back ,  Dawei Jiang ,  Kannan Vembaiyan

Inventor： S.R. Chen ,  Thomas Back ,  Dawei Jiang ,  Kannan Vembaiyan

IPC: C07D209/82 ,  A61K31/403 ,  A61K31/422 ,  A61K31/5377 ,  C07H15/20 ,  C07H3/08 ,  C07D413/12 ,  A61K31/7056 ,  A61P9/00

CPC classification number: C07D209/88 ,  C07D209/82 ,  C07D413/12

Abstract: The present invention provides novel ryanodine receptor type 2 (RyR2) inhibitors and methods of their use in the treatment of cardiac conditions. In general, the RyR2 inhibitors of the present invention assist in the normalization of intracellular calcium homeostasis. In certain embodiments, the RyR2 inhibitors are store-overload-induced Ca2+ release (SOICR) inhibitors that minimally inhibit or do not inhibit Ca2+-induced Ca2+ release (CICR), thereby providing beneficial effects in cardiac therapy.

Abstract translation: 本发明提供了新的兰诺定受体2型（RyR2）抑制剂及其用于治疗心脏病症的方法。 通常，本发明的RyR2抑制剂有助于细胞内钙稳态的归一化。 在某些实施方案中，RyR2抑制剂是储存过量诱导的Ca 2+释放（SOICR）抑制剂，其最低限度地抑制或不抑制Ca 2+诱导的Ca ^{2 + 释放（CICR），从而在心脏治疗中提供有益效果。}

公开(公告)号：US20150207812A1

公开(公告)日：2015-07-23

申请号：US14600885

申请日：2015-01-20

Applicant: Gregory Thomas BACK ,  Patrick Michael CLOKE ,  Stephen Ralph DICATO, JR. ,  Daniel Eugenio ESPINAL ,  Todd Aaron O'BOYLE ,  John Sheldon SERAFINI

Inventor： Gregory Thomas BACK ,  Patrick Michael CLOKE ,  Stephen Ralph DICATO, JR. ,  Daniel Eugenio ESPINAL ,  Todd Aaron O'BOYLE ,  John Sheldon SERAFINI

IPC: H04L29/06

CPC classification number: H04L63/1441 ,  H04L63/1408

Abstract: Computer-implemented systems, methods, and computer-readable media are provided for causing an action to be performed in response to a network communication, such as a malicious network communication. In accordance with some embodiments, a first network communication sent from a client device is received, and a protocol used in the first network communication is determined. Once the protocol is determined, the protocol may be implemented to enable a second network communication with the client device. An action to be performed based at least in part on the protocol may be identified, and an instruction may be sent to the client device in the second network communication.

Abstract translation: 提供了计算机实现的系统，方法和计算机可读介质，用于响应于诸如恶意网络通信的网络通信来执行动作。 根据一些实施例，接收从客户端设备发送的第一网络通信，并且确定在第一网络通信中使用的协议。 一旦确定了协议，则可以实现协议以实现与客户端设备的第二网络通信。 可以至少部分地基于协议来执行要执行的动作，并且可以在第二网络通信中向客户端设备发送指令。