公开(公告)号：US20180044364A1

公开(公告)日：2018-02-15

申请号：US15552661

申请日：2016-02-25

申请人： Conopco, Inc., d/b/a UNILEVER

发明人： Raymond John MARRIOTT ,  Paul Simon STEVENSON

IPC分类号： C07H1/08 ,  B01J20/14 ,  C07H15/06 ,  B01D15/00 ,  B01D11/04

CPC分类号： C07H1/08 ,  B01D11/0403 ,  B01D15/00 ,  B01J20/14 ,  C07H15/04 ,  C07H15/06

摘要： A method of extracting at least one rhamnolipid compound from a rhamnolipid fermentation mixture, the method comprising the steps of: (a) admixing an inert adsorbing support with a rhamnolipid fermentation mixture; (b) dissolving the mixture in an organic solvent at a temperature higher than 31° C. and at a pressure higher than 73 bars; (c) separating at least one fatty compound; (d) adding a co-solvent to said organic solvent; (e) modifying temperature and/or pressure; (f) separating a first rhamnolipid compound; and (g) separating a second rhamnolipid compound.

公开(公告)号：US09586985B2

公开(公告)日：2017-03-07

申请号：US14417487

申请日：2013-07-26

申请人： Callaghan Innovation Research Limited

发明人： Benjamin Jason Compton ,  Colin Malcolm Hayman ,  Ian Francis Hermans ,  David Samuel Larsen ,  Gavin Frank Painter ,  Regan J. Anderson

IPC分类号： C07H15/04 ,  A61K39/39 ,  C07H15/06 ,  A61K39/00

CPC分类号： C07H15/04 ,  A61K39/39 ,  A61K2039/55511 ,  C07H15/06

摘要： This invention relates to sphingoglycolipid analogs, compositions comprising these compounds, processes for preparing the compounds, and methods of treating or preventing diseases or conditions using the compounds, such as diseases or conditions relating to infection, atopic disorders, autoimmune disease, diabetes or cancer.

摘要翻译： 本发明涉及鞘糖脂类似物，包含这些化合物的组合物，用于制备化合物的方法，以及使用该化合物治疗或预防疾病或病症的方法，例如与感染，特应性疾病，自身免疫性疾病，糖尿病或癌症有关的疾病或病症。

公开(公告)号：US09464105B2

公开(公告)日：2016-10-11

申请号：US14419198

申请日：2013-08-02

申请人： RIKEN

发明人： Masao Shiozaki ,  Takuya Tashiro ,  Kenji Mori ,  Tomokuni Shigeura ,  Hiroshi Watarai ,  Masaru Taniguchi

IPC分类号： C07H15/06 ,  C07H15/04 ,  C12N5/06 ,  C12N5/0784 ,  A61K35/17 ,  A61K35/15 ,  A61K35/12

CPC分类号： C07H15/06 ,  A61K35/15 ,  A61K35/17 ,  A61K2035/122 ,  C07H15/04 ,  C12N5/064 ,  C12N2501/999

摘要： The invention provides a compound represented by the formula (I) wherein R1 is a hydrogen atom or a hydroxyl group; two R2 are the same or different and each is a hydrogen atom or a hydroxyl group; R3 is a hydrocarbon group having 8-14 carbon atoms, which optionally has substituent(s); and R4 is a hydrocarbon group having 18-24 carbon atoms, which optionally has substituent(s), or a salt thereof. The invention also provides a method of treating an autoimmune disease or suppressing immunity by administering the aforementioned compound or a salt thereof to a patient in need thereof.

公开(公告)号：US20150152128A1

公开(公告)日：2015-06-04

申请号：US14397184

申请日：2013-04-26

申请人： RIKEN

发明人： Takuya Tashiro ,  Kenji Mori ,  Masao Shiozaki ,  Masaru Taniguchi. ,  Hiroshi Watarai

IPC分类号： C07H15/04

CPC分类号： C07H15/04 ,  C07H15/06 ,  C12N5/06

摘要： The invention provides a compound effective as an antitumor active agent or vaccine adjuvant and an intermediate useful for the synthesis of the compound, as well as production methods thereof, and a medicament containing the novel compound. The compound is a carbamate glycolipid represented by the formula (I) wherein each symbol is as defined herein. The invention also provides a dendritic cell pulsed with the glycolipid.

摘要翻译： 本发明提供了作为抗肿瘤活性剂或疫苗佐剂和可用于合成化合物的中间体及其制备方法和含有该新化合物的药物有效的化合物。 化合物是由式（I）表示的氨基甲酸酯糖脂，其中每个符号如本文所定义。 本发明还提供了用糖脂脉冲的树突状细胞。

公开(公告)号：US09045514B2

公开(公告)日：2015-06-02

申请号：US13574420

申请日：2011-01-20

申请人： Flemming Vang Sparsø ,  Karsten Matthias Kragh ,  Lars Wiebe ,  Rene Mikkelsen ,  Anne Katherine Kjærsgaard Laursen

发明人： Flemming Vang Sparsø ,  Karsten Matthias Kragh ,  Lars Wiebe ,  Rene Mikkelsen ,  Anne Katherine Kjærsgaard Laursen

IPC分类号： C07H15/203 ,  C07H5/06 ,  A23K1/16 ,  A23K1/165 ,  A23L1/03 ,  A23L1/035 ,  A23L1/30 ,  A23L1/305 ,  A23L1/308 ,  A61K8/60 ,  A61Q19/00 ,  C07H15/06 ,  C11D1/42 ,  C11D1/52 ,  C11D1/66 ,  C11D3/22 ,  C11D3/48 ,  C11D7/32

CPC分类号： C07H5/06 ,  A23K20/105 ,  A23K20/189 ,  A23L29/03 ,  A23L29/10 ,  A23L33/10 ,  A23L33/17 ,  A23L33/21 ,  A61K8/60 ,  A61K2800/524 ,  A61Q19/00 ,  C07H15/06 ,  C11D1/42 ,  C11D1/525 ,  C11D1/662 ,  C11D3/227 ,  C11D3/48 ,  C11D7/329

摘要： A method of preparing a compound of formula (I): wherein: a first group selected from R1, R2 and R3 is an amino- or N-acylamino monosaccharide moiety, the acyl group having 1 to 6 carbon atoms, or an oligosaccharide chain comprising 2 to 4 monosaccharide moieties, at least one of which is an amino- or N-acylamino monosaccharide moiety; a second group selected from R1, R2 and R3 is a alkanoyl and alkenoyl acyl group having 3 to 40 carbon atoms; and a third group selected from R1, R2 and R3 is hydrogen, the method comprising contacting a monoacylglycerol, the acyl moiety thereof being a saturated or unsaturated acyl group having 3 to 40 carbon atoms, or an activated derivative thereof, with a source of amino- or N-acylamino monosaccharide moiety, or an activated derivative thereof, and, if required, a source of unsubstituted monosaccharide moiety, or an activated derivative thereof, optionally in the presence of a suitable catalyst or activating agent, is described.

摘要翻译： 一种制备式（I）化合物的方法：其中：选自R 1，R 2和R 3的第一基团是氨基或N-酰基氨基单糖部分，具有1至6个碳原子的酰基或包含 2至4个单糖部分，其中至少一个是氨基或N-酰基氨基单糖部分; 选自R1，R2和R3的第二个基团是具有3-40个碳原子的烷酰基和烯酰基酰基; 并且选自R 1，R 2和R 3的第三基团是氢，所述方法包括使具有3-40个碳原子的饱和或不饱和酰基的酰基部分或其活化衍生物与单酰基甘油与氨基来源 - 或N-酰基氨基单糖部分或其活化衍生物，并且如果需要，可任选在合适的催化剂或活化剂存在下，描述未取代的单糖部分源或其活化衍生物。

公开(公告)号：US08936793B2

公开(公告)日：2015-01-20

申请号：US12225381

申请日：2007-03-30

申请人： Dennis Sprott ,  Dennis M. Whitfield ,  Lakshmi Krishnan

发明人： Dennis Sprott ,  Dennis M. Whitfield ,  Lakshmi Krishnan

IPC分类号： A61K39/395 ,  A61K9/127 ,  A61K39/39 ,  C07H15/06 ,  A61K39/00

CPC分类号： A61K9/1272 ,  A61K39/39 ,  A61K2039/55583 ,  A61K2039/55594 ,  C07H15/06

摘要： Archaeal lipid adjuvants are synthesized by chemically coupling various carbohydrates or anionic polar groups to the free hydroxyl(s) of archaeal lipid cores. Chemically stable lipid cores such as saturated archaeol and caldarchaeol are obtained from appropriate Archaea. Archaeosome lipid vesicles are formulated from the synthetic lipids selected to serve as antigen carriers that target antigen-presenting cells and promote an appropriate immune response to the antigen.

摘要翻译： 通过将各种碳水化合物或阴离子极性基团与古细菌脂质核心的游离羟基化学偶联来合成古菌脂质佐剂。 化学稳定的脂质核，如饱和的古生物和钙质石是从适当的古菌获得的。 从选择用作靶向抗原呈递细胞并促进对抗原的适当免疫应答的抗原载体的合成脂质配制考古细胞脂质囊泡。

公开(公告)号：US20140179781A1

公开(公告)日：2014-06-26

申请号：US13797802

申请日：2013-03-12

申请人： Qualitas Health, Ltd.

发明人： Brian J. WAIBEL ,  Hans Schonemann ,  Val Krukonis ,  Michael Kagan

IPC分类号： A61K31/202 ,  A23L1/30

CPC分类号： A61K31/202 ,  A23L33/12 ,  A23V2002/00 ,  C07H15/06 ,  C11B3/006 ,  C12P7/6427 ,  A23V2250/1846 ,  A23V2250/185 ,  A23V2250/187 ,  A23V2250/2136

摘要： Provided herein are compositions comprising eicosapentaenoic acid (EPA) and polar lipids (e.g., glycolipids and phospholipids), and which do not contain any docosahexaenoic acid (DHA) or esterified fatty acids.

摘要翻译： 本文提供包含二十碳五烯酸（EPA）和极性脂质（例如糖脂和磷脂）的组合物，其不含任何二十二碳六烯酸（DHA）或酯化脂肪酸。

公开(公告)号：US20130217031A1

公开(公告)日：2013-08-22

申请号：US13729265

申请日：2012-12-28

申请人： M BIO TECHNOLOGY INC.

发明人： Kazuhiro Matsuda ,  Yuko Shingu

IPC分类号： C07H15/06 ,  G01N33/569

CPC分类号： C07H15/06 ,  C07K16/1253 ,  C12P7/6463 ,  C12P7/6472 ,  G01N33/56933 ,  G01N2333/30 ,  G01N2400/50 ,  G01N2405/00 ,  G01N2469/10 ,  G01N2469/20

摘要： The present invention provides a novel glyceroglycolipid produced by Mycoplasma pneumoniae. The glyceroglycolipid can be used as a diagnostic marker for a disease caused by Mycoplasma pneumoniae.

公开(公告)号：US20120178705A1

公开(公告)日：2012-07-12

申请号：US13344557

申请日：2012-01-05

申请人： Pi-Hui LIANG

发明人： Pi-Hui LIANG

IPC分类号： A61K31/7034 ,  A61P37/04 ,  C07D213/65 ,  A61P35/00 ,  C07H15/18 ,  C07C59/68

CPC分类号： C07H1/00 ,  A61K39/39 ,  C07B2200/07 ,  C07H15/04 ,  C07H15/06 ,  C07H15/18 ,  Y02P20/55 ,  A61K31/7028 ,  A61K31/715

摘要： Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.

摘要翻译： 提供了α-糖苷脂的合成和制备方法。 提供了α-半乳糖神经酰胺的合成方法及其药物活性类似物及其变体。 提供了新的α-糖苷脂，其中所述化合物是用作NKT（天然杀伤T）细胞配体的免疫原性化合物。

公开(公告)号：US08211859B2

公开(公告)日：2012-07-03

申请号：US12446431

申请日：2007-10-18

申请人： Didier Dubreuil ,  Muriel Pipelier ,  Laurent Micouin ,  Thomas Lecourt ,  Vivien Lacone ,  Marc Bonneville ,  Jacques Lependu ,  Anne-Laure Turcot-Dubois

发明人： Didier Dubreuil ,  Muriel Pipelier ,  Laurent Micouin ,  Thomas Lecourt ,  Vivien Lacone ,  Marc Bonneville ,  Jacques Lependu ,  Anne-Laure Turcot-Dubois

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： C07H15/06 ,  C07H15/14

摘要： The invention relates to α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the α-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize α-galactoceramide analogs by a mere metathesis reaction. The α-galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.

摘要翻译： 本发明涉及α-半乳甘油酰胺类似物，其制备方法，可用于这些方法的中间体化合物。 它还涉及含有α-半乳甘露聚糖类似物的药物组合物。 本发明的制备方法涉及使用不饱和中间体化合物，其能够通过仅仅的复分解反应合成α-半乳甘露聚糖类似物。 本发明的α-半乳糖苷类似物可用作药物组合物的活性成分，特别是在具有抗癌性质的药物组合物中。