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公开(公告)号：US20200245955A1
公开(公告)日：2020-08-06
申请号：US16591802
申请日：2019-10-03
摘要： An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity. A transducer is responsive to the sensor and is capable of creating a stimulus detectable by the subject under certain conditions. In various embodiments, a controller receives signals corresponding to a pitch angle and a roll angle of the subject's head measured by the sensor, determines if the pitch and roll angles correspond to a sleep apnea inducing position, and causes the transducer to generate a stimulus upon determining that the subject's head is in the sleep apnea inducing position more than a predetermined threshold number of times. Various parameters of the stimulus may be modified with successive stimulus generation until a non-sleep apnea inducing position is detected.
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公开(公告)号：US20160367203A1
公开(公告)日：2016-12-22
申请号：US15180579
申请日：2016-06-13
CPC分类号： A61B5/746 , A61B5/002 , A61B5/08 , A61B5/1075 , A61B5/1121 , A61B5/4818 , A61B5/6817 , A61B5/7278 , A61B5/7405 , A61B5/7455 , A61B2562/0219 , A61B2562/04 , G08B21/06 , H04B1/02
摘要： An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity. A transducer is responsive to the sensor and is capable of creating a stimulus detectable by the subject under certain conditions. In various embodiments, a controller receives signals corresponding to a pitch angle and a roll angle of the subject's head measured by the sensor, determines if the pitch and roll angles correspond to a sleep apnea inducing position, and causes the transducer to generate a stimulus upon determining that the subject's head is in the sleep apnea inducing position more than a predetermined threshold number of times. Various parameters of the stimulus may be modified with successive stimulus generation until a non-sleep apnea inducing position is detected.
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公开(公告)号：US09368016B2
公开(公告)日：2016-06-14
申请号：US14103945
申请日：2013-12-12
CPC分类号： A61B5/746 , A61B5/002 , A61B5/08 , A61B5/1075 , A61B5/1121 , A61B5/4818 , A61B5/6817 , A61B5/7278 , A61B5/7405 , A61B5/7455 , A61B2562/0219 , A61B2562/04 , G08B21/06 , H04B1/02
摘要： An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity. A transducer is responsive to the sensor and is capable of creating a stimulus detectable by the subject under certain conditions. In various embodiments, a controller receives signals corresponding to a pitch angle and a roll angle of the subject's head measured by the sensor, determines if the pitch and roll angles correspond to a sleep apnea inducing position, and causes the transducer to generate a stimulus upon determining that the subject's head is in the sleep apnea inducing position more than a predetermined threshold number of times. Various parameters of the stimulus may be modified with successive stimulus generation until a non-sleep apnea inducing position is detected.
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公开(公告)号：US20120041343A1
公开(公告)日：2012-02-16
申请号：US13207073
申请日：2011-08-10
IPC分类号： A61B5/103
CPC分类号： A61B5/746 , A61B5/002 , A61B5/08 , A61B5/1075 , A61B5/1121 , A61B5/4818 , A61B5/6817 , A61B5/7278 , A61B5/7405 , A61B5/7455 , A61B2562/0219 , A61B2562/04 , G08B21/06 , H04B1/02
摘要： An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity. A transducer is responsive to the sensor and is capable of creating a stimulus detectable by the subject under certain conditions. In various embodiments, a controller receives signals corresponding to a pitch angle and a roll angle of the subject's head measured by the sensor, determines if the pitch and roll angles correspond to a sleep apnea inducing position, and causes the transducer to generate a stimulus upon determining that the subject's head is in the sleep apnea inducing position more than a predetermined threshold number of times. Various parameters of the stimulus may be modified with successive stimulus generation until a non-sleep apnea inducing position is detected.
摘要翻译： 用于检测睡眠障碍（例如阻塞性睡眠呼吸暂停）的装置包括可插入到受试者的耳道中的壳体。 设置在壳体内的传感器测量被检者的头部相对于重心的位置。 传感器响应于传感器，并且能够在某些条件下产生可由受试者检测的刺激物。 在各种实施例中，控制器接收对应于由传感器测量的对象头部的俯仰角和侧倾角的信号，确定俯仰角和倾斜角是否对应于睡眠呼吸暂停诱导位置，并且使得换能器产生刺激 确定受试者的头部处于睡眠呼吸暂停诱导位置超过预定阈值次数。 可以用连续的刺激生成修改刺激的各种参数，直到检测到非睡眠呼吸暂停诱导位置。
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公开(公告)号：US20140225736A1
公开(公告)日：2014-08-14
申请号：US14103945
申请日：2013-12-12
IPC分类号： G08B21/06
CPC分类号： A61B5/746 , A61B5/002 , A61B5/08 , A61B5/1075 , A61B5/1121 , A61B5/4818 , A61B5/6817 , A61B5/7278 , A61B5/7405 , A61B5/7455 , A61B2562/0219 , A61B2562/04 , G08B21/06 , H04B1/02
摘要： An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity. A transducer is responsive to the sensor and is capable of creating a stimulus detectable by the subject under certain conditions. In various embodiments, a controller receives signals corresponding to a pitch angle and a roll angle of the subject's head measured by the sensor, determines if the pitch and roll angles correspond to a sleep apnea inducing position, and causes the transducer to generate a stimulus upon determining that the subjects head is in the sleep apnea inducing position more than a predetermined threshold number of times. Various parameters of the stimulus may be modified with successive stimulus generation until a non-sleep apnea inducing position is detected.
摘要翻译： 用于检测睡眠障碍（例如阻塞性睡眠呼吸暂停）的装置包括可插入到受试者的耳道中的壳体。 设置在壳体内的传感器测量被检者的头部相对于重心的位置。 传感器响应于传感器，并且能够在某些条件下产生可由受试者检测的刺激物。 在各种实施例中，控制器接收对应于由传感器测量的对象头部的俯仰角和侧倾角的信号，确定俯仰角和俯仰角是否对应于睡眠呼吸暂停诱导位置，并且使得换能器产生刺激 确定受试者头部处于睡眠呼吸暂停诱导位置超过预定阈值次数。 可以用连续的刺激生成修改刺激的各种参数，直到检测到非睡眠呼吸暂停诱导位置。
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公开(公告)号：US10433794B2
公开(公告)日：2019-10-08
申请号：US15180579
申请日：2016-06-13
摘要： An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity. A transducer is responsive to the sensor and is capable of creating a stimulus detectable by the subject under certain conditions. In various embodiments, a controller receives signals corresponding to a pitch angle and a roll angle of the subject's head measured by the sensor, determines if the pitch and roll angles correspond to a sleep apnea inducing position, and causes the transducer to generate a stimulus upon determining that the subject's head is in the sleep apnea inducing position more than a predetermined threshold number of times. Various parameters of the stimulus may be modified with successive stimulus generation until a non-sleep apnea inducing position is detected.
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公开(公告)号：US09092965B2
公开(公告)日：2015-07-28
申请号：US13207073
申请日：2011-08-10
CPC分类号： A61B5/746 , A61B5/002 , A61B5/08 , A61B5/1075 , A61B5/1121 , A61B5/4818 , A61B5/6817 , A61B5/7278 , A61B5/7405 , A61B5/7455 , A61B2562/0219 , A61B2562/04 , G08B21/06 , H04B1/02
摘要： An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity. A transducer is responsive to the sensor and is capable of creating a stimulus detectable by the subject under certain conditions. In various embodiments, a controller receives signals corresponding to a pitch angle and a roll angle of the subject's head measured by the sensor, determines if the pitch and roll angles correspond to a sleep apnea inducing position, and causes the transducer to generate a stimulus upon determining that the subject's head is in the sleep apnea inducing position more than a predetermined threshold number of times. Various parameters of the stimulus may be modified with successive stimulus generation until a non-sleep apnea inducing position is detected.
摘要翻译： 用于检测睡眠障碍（例如阻塞性睡眠呼吸暂停）的装置包括可插入到受试者的耳道中的壳体。 设置在壳体内的传感器测量被检者的头部相对于重心的位置。 传感器响应于传感器，并且能够在某些条件下产生可由受试者检测的刺激物。 在各种实施例中，控制器接收对应于由传感器测量的对象头部的俯仰角和侧倾角的信号，确定俯仰角和俯仰角是否对应于睡眠呼吸暂停诱导位置，并且使得换能器产生刺激 确定受试者的头部处于睡眠呼吸暂停诱导位置超过预定阈值次数。 可以用连续的刺激生成修改刺激的各种参数，直到检测到非睡眠呼吸暂停诱导位置。
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公开(公告)号：US20130021158A1
公开(公告)日：2013-01-24
申请号：US13627597
申请日：2012-09-26
IPC分类号： G08B21/06
CPC分类号： A61B5/746 , A61B5/002 , A61B5/08 , A61B5/1075 , A61B5/1121 , A61B5/4818 , A61B5/6817 , A61B5/7278 , A61B5/7405 , A61B5/7455 , A61B2562/0219 , A61B2562/04 , G08B21/06 , H04B1/02
摘要： An apparatus for detecting sleep disorders, such as obstructive sleep apnea, includes a housing insertable into an ear canal of a subject. A sensor disposed within the housing measures a position of the subject's head relative to an axis of gravity. A transducer is responsive to the sensor and is capable of creating a stimulus detectable by the subject under certain conditions. In various embodiments, a controller receives signals corresponding to a pitch angle and a roll angle of the subject's head measured by the sensor, determines if the pitch and roll angles correspond to a sleep apnea inducing position, and causes the transducer to generate a stimulus upon determining that the subject's head is in the sleep apnea inducing position more than a predetermined threshold number of times. Various parameters of the stimulus may be modified with successive stimulus generation until a non-sleep apnea inducing position is detected.
摘要翻译： 用于检测睡眠障碍（例如阻塞性睡眠呼吸暂停）的装置包括可插入到受试者的耳道中的壳体。 设置在壳体内的传感器测量被检者的头部相对于重心的位置。 传感器响应于传感器，并且能够在某些条件下产生可由受试者检测的刺激物。 在各种实施例中，控制器接收对应于由传感器测量的对象头部的俯仰角和侧倾角的信号，确定俯仰角和倾斜角是否对应于睡眠呼吸暂停诱导位置，并且使得换能器产生刺激 确定受试者的头部处于睡眠呼吸暂停诱导位置超过预定阈值次数。 可以用连续的刺激生成修改刺激的各种参数，直到检测到非睡眠呼吸暂停诱导位置。
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9.发明授权公开(公告)号：US08809001B2
公开(公告)日：2014-08-19
申请号：US12679753
申请日：2008-09-23
IPC分类号： G01N33/53 , C12Q1/54 , C12Q1/02 , G01N33/566 , C07K14/72
CPC分类号： G01N33/566 , C07K14/72 , G01N2333/723 , G01N2500/10
摘要： The subject invention provides methods of screening compounds or ligands that interact with human and/or non-human PAQR receptors or fungal osmotin receptors. These methods utilize a colorimetric assay to ascertain whether a compound binds to and activates a PAQR receptor or the osmotin receptor.
摘要翻译： 本发明提供了筛选与人和/或非人类PAQR受体或真菌渗透素受体相互作用的化合物或配体的方法。 这些方法利用比色测定来确定化合物是否结合并激活PAQR受体或氧化蛋白受体。
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公开(公告)号：US6050366A
公开(公告)日：2000-04-18
申请号：US232143
申请日：1999-01-15
申请人： Charles Thomas Lyons
发明人： Charles Thomas Lyons
CPC分类号： E04H3/123 , E04F11/06 , Y10S414/134
摘要： A combined stairway and lift installation has a stairway which comprises a stack of horizontally movable step members whereby the stairway is retractable to expose a lift which is installed in a cavity which is covered by the stairway when the latter is extended. Uncovering of the lift allows it to be operated to raise its load carrying platform to the level of the top of the stairway. A chain is anchored by either end in the bottom step member. The chain is led from the anchorage up through the step members, alternately clockwise and counter clockwise around guide rollers mounted in each of the movable step members, clockwise around a guide roller and a motor-driven cog wheel in the top step member, and back down through the movable step members to the other anchorage again alternately clockwise and counter clockwise around further guide rollers mounted in each of the movable step members. The motor is reversible so that in one sense it drives the movable step members to form the stairway and in the other sense it drives them to their retracted position.
摘要翻译： 组合的楼梯和升降机装置具有楼梯，该楼梯包括一堆可水平移动的台阶构件，由此楼梯可伸缩以露出安装在由楼梯延伸的空间中的楼梯的升降机。 升降机的拆卸允许其操作以将其承载平台升高到楼梯顶部的水平。 链条由底部部件中的任一端锚定。 链条从锚固件向上穿过台阶部件，交替地顺时针和逆时针方向围绕安装在每个可移动台阶部件中的引导辊顺时针绕在顶部步骤部件中的引导辊和电动驱动齿轮上，并且返回 通过可移动的踏板部件向下再次交替地顺时针和逆时针地绕安装在每个可移动台阶部件中的另外的导向辊。 电动机是可逆的，从而在某种意义上，它驱动可移动的台阶部件以形成楼梯，并且在另一方面它驱动它们到缩回位置。
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