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公开(公告)号：US08846113B2
公开(公告)日：2014-09-30
申请号：US13304604
申请日：2011-11-25
申请人： Barry Quart , David Rosenbaum , Thomas Neenan , Robert Blanks
发明人： Barry Quart , David Rosenbaum , Thomas Neenan , Robert Blanks
IPC分类号： A61K36/00 , A61K36/38 , A61K31/365 , A61K31/426 , A61K36/47
CPC分类号： A61K31/353 , A61K9/28 , A61K31/365 , A61K31/426 , A61K36/38 , A61K36/47
摘要： The present invention provides methods for treating diarrhea-predominant irritable bowel syndrome comprising administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea-predominant irritable bowel syndrome (d-IBS). Treatment of d-IBS includes the treatment of the diarrhea component of d-IBS as well as the pain, abdominal discomfort and other symptoms associated with d-IBS. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.
摘要翻译： 本发明提供了治疗腹泻型肠易激综合征综合征的方法，其包括向有需要的患者施用足以治疗腹泻型肠易激综合征（d-IBS）的氯离子转运抑制剂。 d-IBS的治疗包括治疗d-IBS的腹泻成分以及与d-IBS相关的疼痛，腹部不适和其他症状。 在一个实施方案中，氯离子转运抑制剂是疏水剂。
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2.发明申请公开(公告)号：US20150050338A1
公开(公告)日：2015-02-19
申请号：US14466089
申请日：2014-08-22
IPC分类号： A61K31/353 , A61K36/47 , A61K9/28
CPC分类号： A61K31/353 , A61K9/28 , A61K31/365 , A61K31/426 , A61K36/38 , A61K36/47
摘要： The present invention provides methods for treating diarrhea-predominant irritable bowel syndrome comprising administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea-predominant irritable bowel syndrome (d-IBS). Treatment of d-IBS includes the treatment of the diarrhea component of d-IBS as well as the pain, abdominal discomfort and other symptoms associated with d-IBS. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.
摘要翻译： 本发明提供了治疗腹泻型肠易激综合征综合征的方法，其包括向有需要的患者施用足以治疗腹泻型肠易激综合征（d-IBS）的氯离子转运抑制剂。 d-IBS的治疗包括治疗d-IBS的腹泻成分以及与d-IBS相关的疼痛，腹部不适和其他症状。 在一个实施方案中，氯离子转运抑制剂是疏水剂。
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