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1.发明申请Liposomal Composition for Convection-Enhanced Delivery to the Central Nervous Centre 有权对流增强交付给中枢神经中心的脂质体组成公开(公告)号：US20110274625A1
公开(公告)日：2011-11-10
申请号：US13130525
申请日：2009-11-23
申请人： Thomas Redelmeier , Matthias Luz
发明人： Thomas Redelmeier , Matthias Luz
CPC分类号： A61K49/0084 , A61K9/0019 , A61K9/127 , A61K31/4745 , A61K49/0023 , A61K49/0041 , A61M25/007 , A61M2025/0042
摘要： Convection-enhanced delivery (CED) is used as a method to deliver a direct infusion of therapeutic agents to the central nervous centre thus circumventing the blood-blood barrier. A non-PEGylated liposomal composition comprising at least one saturated neutral phospholipid and at least one saturated anionic phospholipid and a therapeutic or diagnostic agent encapsulated therein is used to overcome toxicity associated with high peak drug concentration delivered locally CED as well as to increase tissue distribution volume for an improved sustained drug release. In one embodiment, the liposome composition comprises a molar ratio of DSPC:DSPG:CHOL of 7:2:1 and the therapeutic or diagnostic agent is selected from topotecan, conotoxin, gadodiamide or rhodamine, and is used in the treatment of epilepsy
摘要翻译： 对流增强递送（CED）用作将治疗剂直接输注到中枢神经中枢的方法，从而绕过血液屏障。 使用包含至少一种饱和中性磷脂和至少一种饱和阴离子磷脂和其中包封的治疗或诊断剂的非PEG化脂质体组合物来克服与局部CED递送的高峰药物浓度相关的毒性以及增加组织分布体积 用于改善持续的药物释放。 在一个实施方案中，脂质体组合物包含7:2:1的DSPC：DSPG：CHOL的摩尔比，治疗或诊断剂选自拓扑替康，芋螺毒素，钆二胺或罗丹明，并且用于治疗癫痫
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2.发明授权Liposomal composition for convection-enhanced delivery to the central nervous centre 有权用于对流增强输送到中枢神经中心的脂质体组成公开(公告)号：US09295735B2
公开(公告)日：2016-03-29
申请号：US13130525
申请日：2009-11-23
申请人： Thomas Redelmeier , Matthias Luz
发明人： Thomas Redelmeier , Matthias Luz
IPC分类号： A61K9/127 , A61K49/00 , A61K9/00 , A61K31/4745 , A61M25/00
CPC分类号： A61K49/0084 , A61K9/0019 , A61K9/127 , A61K31/4745 , A61K49/0023 , A61K49/0041 , A61M25/007 , A61M2025/0042
摘要： Convection-enhanced delivery (CED) is used as a method to deliver a direct infusion of therapeutic agents to the central nervous center thus circumventing the blood-blood barrier. A non-PEGylated liposomal composition comprising at least one saturated neutral phospholipid and at least one saturated anionic phospholipid and a therapeutic or diagnostic agent encapsulated therein is used to overcome toxicity associated with high peak drug concentration delivered locally CED as well as to increase tissue distribution volume for an improved sustained drug release. In one embodiment, the liposome composition comprises a molar ratio of DSPC:DSPG:CHOL of 7:2:1 and the therapeutic or diagnostic agent is selected from topotecan, conotoxin, gadodiamide or rhodamine, and is used in the treatment of epilepsy.
摘要翻译： 对流增强递送（CED）用作将治疗剂直接输注到中枢神经中枢的方法，从而绕过血液屏障。 使用包含至少一种饱和中性磷脂和至少一种饱和阴离子磷脂和其中包封的治疗或诊断剂的非PEG化脂质体组合物来克服与局部CED递送的高峰药物浓度相关的毒性以及增加组织分布体积 用于改善持续的药物释放。 在一个实施方案中，脂质体组合物包含7:2:1的DSPC:DSPG:CHOL的摩尔比，治疗或诊断剂选自拓扑替康，芋螺毒素，钆二胺或罗丹明，并用于治疗癫痫。
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公开(公告)号：US07029695B2
公开(公告)日：2006-04-18
申请号：US09903442
申请日：2001-07-10
申请人： Thomas Redelmeier , Lawrence M. Kauvar , Robert T. Lum , Matthew H. Lyttle , Robert W. Macsata , Steven R. Schow , Hugo O. Villar , Michael R. Kozlowski
发明人： Thomas Redelmeier , Lawrence M. Kauvar , Robert T. Lum , Matthew H. Lyttle , Robert W. Macsata , Steven R. Schow , Hugo O. Villar , Michael R. Kozlowski
CPC分类号： A61K9/1075 , A61K9/127 , A61K38/063
摘要： Pharmaceutical compositions and methods of using them. Lipid formulations of a glutathione analog and methods of manufacturing them. Their use to stimulate hematopoiesis, protect hematopoietic cells from damage caused by radiation or chemotherapy, or potentiate the stimulatory action of one or a combination of cytokines on colony formation by hematopoietic progenitor cells, protect a subject from a destructive effect of a chemotherapeutic agent or irradiation, or to potentiate the effect of a chemotherapeutic agent.
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