公开(公告)号：US20050208527A1

公开(公告)日：2005-09-22

申请号：US10995011

申请日：2004-11-22

申请人： Hreinn Stefansson ,  Valgerdur Steinthorsdottir ,  Jeffrey Gulcher ,  Mark Gurney ,  Thorkell Andresson

发明人： Hreinn Stefansson ,  Valgerdur Steinthorsdottir ,  Jeffrey Gulcher ,  Mark Gurney ,  Thorkell Andresson

IPC分类号： A61K38/17 ,  A61K38/18 ,  C12Q1/68

CPC分类号： C07K14/4756 ,  A01K67/0276 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/00 ,  C07K2319/00 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172 ,  G01N2500/04 ,  G01N2800/2835

摘要： Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides; antibodies that bind to NRG1 polypeptides; methods of diagnosis of susceptibility to schizophrenia; assays for agents that alter the activity of NRG1 polypeptide or which identify NRG1 binding agents, and the agents or binding agents identified by the assays; NRG1 therapeutic agents, including the NRG1 nucleic acids, NRG1 polypeptides, or agents that alter the activity of an NRG1 polypeptides; pharmaceutical compositions comprising the NRG1 therapeutic agents; as well as methods of therapy of schizophrenia. Novel haplotypes with a common core haplotype in affected individuals are described, as well as their use in methods for screening for susceptibility to schizophrenia. Also described are hypomorphic mice for use in identifying phenotypes associated with schizophrenia, as well as for use in assessing agents of interest for neuroleptic activity and for potential therapeutic use for treatment of schizophrenia.

摘要翻译： 公开了包含神经调节蛋白1基因（NRG1）和编码NRG1多肽的核酸。 还描述了编码NRG1多肽的相关核酸; NRG1多肽; 结合NRG1多肽的抗体; 精神分裂症易感性诊断方法; 用于改变NRG1多肽的活性或鉴定NRG1结合剂的试剂的测定法和通过测定鉴定的试剂或结合剂; NRG1治疗剂，包括NRG1核酸，NRG1多肽或改变NRG1多肽活性的试剂; 包含NRG1治疗剂的药物组合物; 以及精神分裂症治疗方法。 描述了在受影响个体中具有共同核心单体型的新型单元型，以及它们在筛选易感性精神分裂症的方法中的用途。 还描述了用于鉴定与精神分裂症相关的表型的同型小鼠，以及用于评估精神兴奋活性感兴趣的药物和用于治疗精神分裂症的潜在治疗用途。

公开(公告)号：US07495147B2

公开(公告)日：2009-02-24

申请号：US10107604

申请日：2002-03-26

申请人： Hreinn Stefansson ,  Valgerdur Steinthorsdottir ,  Jeffrey R. Gulcher ,  Mark Gurney ,  Thorkell Andresson

发明人： Hreinn Stefansson ,  Valgerdur Steinthorsdottir ,  Jeffrey R. Gulcher ,  Mark Gurney ,  Thorkell Andresson

IPC分类号： G01N33/00 ,  A01K67/00 ,  A01K67/027

CPC分类号： C07K14/4756 ,  A01K67/0276 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/00 ,  A61K38/179 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2800/2835 ,  G01N2800/302

摘要： Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides; antibodies that bind to NRG1 polypeptides; methods of diagnosis of susceptibility to schizophrenia; assays for agents that alter the activity of NRG1 polypeptide or which identify NRG1 binding agents, and the gents or binding agents identified by the assays; NRG1 therapeutic agents, including the NRG1 nucleic acids, NRG1 polypeptides, or agents that alter the activity of an NRG1 polypeptides; pharmaceutical compositions comprising the NRG1 therapeutic agents; as well as methods of therapy of schizophrenia. Novel haplotypes with a common core haplotype in affected individuals are described, as well as their use in methods for screening for susceptibility to schizophrenia. Also described are hypomorphic mice for use in identifying phenotypes associated with schizophrenia, as well as for use in assessing agents of interest for neuroleptic activity and for potential therapeutic use for treatment of schizophrenia.

摘要翻译： 公开了包含神经调节蛋白1基因（NRG1）和编码NRG1多肽的核酸。 还描述了编码NRG1多肽的相关核酸; NRG1多肽; 结合NRG1多肽的抗体; 精神分裂症易感性诊断方法; 用于改变NRG1多肽的活性或鉴定NRG1结合剂的试剂的测定法，以及通过测定鉴定的口感或结合剂; NRG1治疗剂，包括NRG1核酸，NRG1多肽或改变NRG1多肽活性的试剂; 包含NRG1治疗剂的药物组合物; 以及精神分裂症治疗方法。 描述了在受影响个体中具有共同核心单体型的新型单元型，以及它们在筛选易感性精神分裂症的方法中的用途。 还描述了用于鉴定与精神分裂症相关的表型的同型小鼠，以及用于评估精神兴奋活性感兴趣的药物和用于治疗精神分裂症的潜在治疗用途。

公开(公告)号：US20080263690A1

公开(公告)日：2008-10-23

申请号：US10107604

申请日：2002-03-26

申请人： Hreinn Stefansson ,  Valgerdur Steinthorsdottir ,  Jeffrey R. Gulcher ,  Mark Gurney ,  Thorkell Andresson

发明人： Hreinn Stefansson ,  Valgerdur Steinthorsdottir ,  Jeffrey R. Gulcher ,  Mark Gurney ,  Thorkell Andresson

IPC分类号： A01K67/027 ,  C12Q1/68

CPC分类号： C07K14/4756 ,  A01K67/0276 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/00 ,  A61K38/179 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2800/2835 ,  G01N2800/302

摘要： Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides; antibodies that bind to NRG1 polypeptides; methods of diagnosis of susceptibility to schizophrenia; assays for agents that alter the activity of NRG1 polypeptide or which identify NRG1 binding agents, and the agents or binding agents identified by the assays; NRG1 therapeutic agents, including the NRG1 nucleic acids, NRG1 polypeptides, or agents that alter the activity of an NRG1 polypeptides; pharmaceutical compositions comprising the NRG1 therapeutic agents; as well as methods of therapy of schizophrenia. Novel haplotypes with a common core haplotype in affected individuals are described, as well as their use in methods for screening for susceptibility to schizophrenia. Also described are hypomorphic mice for use in identifying phenotypes associated with schizophrenia, as well as for use in assessing agents of interest for neuroleptic activity and for potential therapeutic use for treatment of schizophrenia.

摘要翻译： 公开了包含神经调节蛋白1基因（NRG1）和编码NRG1多肽的核酸。 还描述了编码NRG1多肽的相关核酸; NRG1多肽; 结合NRG1多肽的抗体; 精神分裂症易感性诊断方法; 用于改变NRG1多肽的活性或鉴定NRG1结合剂的试剂的测定法和通过测定鉴定的试剂或结合剂; NRG1治疗剂，包括NRG1核酸，NRG1多肽或改变NRG1多肽活性的试剂; 包含NRG1治疗剂的药物组合物; 以及精神分裂症治疗方法。 描述了在受影响个体中具有共同核心单体型的新型单元型，以及它们在筛选易感性精神分裂症的方法中的用途。 还描述了用于鉴定与精神分裂症相关的表型的同型小鼠，以及用于评估精神兴奋活性感兴趣的药物和用于治疗精神分裂症的潜在治疗用途。