公开(公告)号：US09133195B2

公开(公告)日：2015-09-15

申请号：US12305174

申请日：2007-06-15

申请人： Runtao Li ,  Qi Sun ,  Jia Ye ,  Caiqin Yue ,  Xin Wang ,  Zemei Ge ,  Changling Li ,  Tieming Cheng

发明人： Runtao Li ,  Qi Sun ,  Jia Ye ,  Caiqin Yue ,  Xin Wang ,  Zemei Ge ,  Changling Li ,  Tieming Cheng

IPC分类号： A61K31/55 ,  C07D471/10 ,  A61K31/438 ,  A61K31/5386 ,  C07D498/10 ,  C07D487/10 ,  C07D513/10 ,  C07D519/00

CPC分类号： C07D471/10 ,  C07D487/10 ,  C07D498/10 ,  C07D513/10 ,  C07D519/00

摘要： Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives, prodrugs or pharmaceutically acceptable salts, and their preparation methods or uses for the manufacture of a medicament of analgesics. In which R1 is selected from H, substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl; A is bond, or saturated or unsaturated straight-chain or branched-chain hydrocarbon radical; R2, R3 are each independently hydrogen or methyl, which linked with any position of spirocyclo-structure; n and m are each independently integer between 0-2, do not represent 0 at the same time; B and D are each independently C1-C3 straight-chain or branched-chain alkylene; Y is selected from —CHR4—, O, S, —S(O)—, —SO2—, —NR4— and substituted or unsubstituted phenylene, in which R4 represents H, C1-C6 saturated or unsaturated alkyl, methyl or ethyl substituted by substituted or unsubstituted aryl or heteroaryl; and X− is pharmaceutical acceptable organic or inorganic anion. These compounds can be used as muscarine receptor (M-receptor) and/or nicotine acetylcholine receptor (N-receptor) agonist or antagonist. These compounds have good analgesic effect without side effect such as addiction.

摘要翻译： 由通式（I）表示的化合物，其立体异构体，互变异构体，衍生物，前药或药学上可接受的盐，及其制备方法或用途，用于制备镇痛药物。 其中R1选自H，取代或未取代的苯基或取代或未取代的杂芳基; A是键或饱和或不饱和的直链或支链烃基; R2，R3各自独立地为氢或甲基，其与任何位置的螺环结构连接; n和m各自独立地为0-2之间的整数，不同时为0; B和D各自独立地为C1-C3直链或支链亚烷基; Y选自-CHR 4 - ，O，S，-S（O） - ， - SO 2 - ， - NR 4 - 和取代或未取代的亚苯基，其中R 4表示H，C 1 -C 6饱和或不饱和烷基，甲基或乙基取代 由取代或未取代的芳基或杂芳基取代; X-是药学上可接受的有机或无机阴离子。 这些化合物可用作毒蕈碱受体（M-受体）和/或尼古丁乙酰胆碱受体（N-受体）激动剂或拮抗剂。 这些化合物具有良好的止痛效果，无副作用，如成瘾。

公开(公告)号：US20090325929A1

公开(公告)日：2009-12-31

申请号：US12305174

申请日：2007-06-15

申请人： Runtao Li ,  Qi Sun ,  Jia Ye ,  Caiqin Yue ,  Xin Wang ,  Zemei Ge ,  Changling Li ,  Tieming Cheng

发明人： Runtao Li ,  Qi Sun ,  Jia Ye ,  Caiqin Yue ,  Xin Wang ,  Zemei Ge ,  Changling Li ,  Tieming Cheng

IPC分类号： A61K31/55 ,  C07D471/10 ,  A61K31/438 ,  A61K31/5386 ,  C07D498/10 ,  C07D487/10

CPC分类号： C07D471/10 ,  C07D487/10 ,  C07D498/10 ,  C07D513/10 ,  C07D519/00

摘要： Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives, prodrugs or pharmaceutically acceptable salts, and their preparation methods or uses for the manufacture of a medicament of analgesics. In which R1 is selected from H, substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl; A is bond, or saturated or unsaturated straight-chain or branched-chain hydrocarbon radical; R2, R3 are each independently hydrogen or methyl, which linked with any position of spirocyclo-structure; n and m are each independently integer between 0-2, do not represent 0 at the same time; B and D are each independently C1-C3 straight-chain or branched-chain alkylene; Y is selected from —CHR4—, O, S, —S(O)—, —SO2—, —NR4— and substituted or unsubstituted phenylene, in which R4 represents H, C1-C6 saturated or unsaturated alkyl, methyl or ethyl substituted by substituted or unsubstituted aryl or heteroaryl; and X− is pharmaceutical acceptable organic or inorganic anion. These compounds can be used as muscarine receptor (M-receptor) and/or nicotine acetylcholine receptor (N-receptor) agonist or antagonist. These compounds have good analgesic effect without side effect such as addiction.

摘要翻译： 由通式（I）表示的化合物，其立体异构体，互变异构体，衍生物，前药或药学上可接受的盐，及其制备方法或用途，用于制备镇痛药物。 其中R1选自H，取代或未取代的苯基或取代或未取代的杂芳基; A是键或饱和或不饱和的直链或支链烃基; R2，R3各自独立地为氢或甲基，其与螺环结构的任何位置连接; n和m各自独立地为0-2之间的整数，不同时为0; B和D各自独立地为C1-C3直链或支链亚烷基; Y选自-CHR 4 - ，O，S，-S（O） - ， - SO 2 - ， - NR 4 - 和取代或未取代的亚苯基，其中R 4表示H，C 1 -C 6饱和或不饱和烷基，甲基或乙基取代 由取代或未取代的芳基或杂芳基取代; X-是药学上可接受的有机或无机阴离子。 这些化合物可用作毒蕈碱受体（M-受体）和/或尼古丁乙酰胆碱受体（N-受体）激动剂或拮抗剂。 这些化合物具有良好的止痛效果，无副作用，如成瘾。

公开(公告)号：US08566671B1

公开(公告)日：2013-10-22

申请号：US13538927

申请日：2012-06-29

申请人： Jia Ye ,  Mrinal Kochar ,  Jianmin Huang

发明人： Jia Ye ,  Mrinal Kochar ,  Jianmin Huang

IPC分类号： G11C29/00

CPC分类号： G06F11/1048 ,  G11C16/00 ,  G11C29/42 ,  G11C2029/0409 ,  G11C2029/0411

摘要： Data errors in non-volatile memory inevitably increase with usage and with higher density of bits stored per cell. The memory is configured to have a first portion operating with less error but of lower density storage, and a second portion operating with a higher density but less robust storage. An error management provides reading and checking the copy after copying to the second portion. If the copy has excessive error bits, it is repeated in a different location either in the second or first portion. The reading and checking of the copy is accelerated by reading only a sample of it. The sample is selected from a subset of the copy having its own ECC, where the sample selected depends on the count of erase-program cycles that a block has experienced, where different count ranges can use different samples.

摘要翻译： 非易失性存储器中的数据错误不可避免地随着使用而增加，并且每个单元存储更高密度的位。 存储器被配置为具有以较小误差但是较低密度存储器操作的第一部分，以及以较高密度但较不牢固的存储器操作的第二部分。 错误管理在复制到第二部分后提供读取和检查副本。 如果副本具有过多的错误位，则在第二或第一部分的不同位置重复该复制。 通过只读取样本来读取和检查副本。 从具有其自己的ECC的副本的子集中选择样本，其中所选择的样本取决于块经历的擦除 - 编程周期的计数，其中不同的计数范围可以使用不同的样本。

公开(公告)号：US08443448B2

公开(公告)日：2013-05-14

申请号：US12544652

申请日：2009-08-20

申请人： Danny Brando ,  Joonho Lee ,  Jia Ye

发明人： Danny Brando ,  Joonho Lee ,  Jia Ye

IPC分类号： G06F21/00

CPC分类号： G06F21/56 ,  G06F8/61 ,  G06F9/44536

摘要： A system and method for performing a security check may include using at least one processor to periodically check a status of a flag, generate and store a baseline representation of modules stored on the device where the flag is determined to be set to a first state, and, where the flag is determined to be set to a second state, generate an active representation of modules stored on the first device, compare the active representation of modules to the baseline representation of modules, and, responsive to a determination in the comparing step of a difference between the baseline and active representations of modules, output an alert. The flag status may depend on an association of the device with one of a plurality of authorization policies, each mapped to one of the two states. Results of the comparison may be appended to an activity log of the device.

摘要翻译： 用于执行安全检查的系统和方法可以包括使用至少一个处理器来周期性地检查标志的状态，生成并存储存储在设备上的模块的基线表示，其中该标志被确定为设置为第一状态， 并且在所述标志被确定为被设置为第二状态的情况下，生成存储在所述第一设备上的模块的活动表示，将模块的活动表示与模块的基线表示进行比较，并且响应于所述比较步骤中的确定 模块的基线和活动表示之间的区别，输出警报。 标志状态可以取决于设备与多个授权策略之一的关联，每个映射到两个状态之一。 比较结果可以追加到设备的活动日志中。

公开(公告)号：US08898791B2

公开(公告)日：2014-11-25

申请号：US13892849

申请日：2013-05-13

申请人： Danny Brando ,  Joonho Lee ,  Jia Ye

发明人： Danny Brando ,  Joonho Lee ,  Jia Ye

IPC分类号： G06F12/00 ,  G06F9/445 ,  G06F21/56

CPC分类号： G06F21/56 ,  G06F8/61 ,  G06F9/44536

摘要： A system and method for performing a security check may include using at least one processor to periodically check a status of a flag, generate and store a baseline representation of modules stored on the device where the flag is determined to be set to a first state, and, where the flag is determined to be set to a second state, generate an active representation of modules stored on the first device, compare the active representation of modules to the baseline representation of modules, and, responsive to a determination in the comparing step of a difference between the baseline and active representations of modules, output an alert. The flag status may depend on an association of the device with one of a plurality of authorization policies, each mapped to one of the two states. Results of the comparison may be appended to an activity log of the device.

摘要翻译： 用于执行安全检查的系统和方法可以包括使用至少一个处理器来周期性地检查标志的状态，生成并存储存储在设备上的模块的基线表示，其中该标志被确定为设置为第一状态， 并且在所述标志被确定为被设置为第二状态的情况下，生成存储在所述第一设备上的模块的活动表示，将模块的活动表示与模块的基线表示进行比较，并且响应于所述比较步骤中的确定 模块的基线和活动表示之间的差异，输出警报。 标志状态可以取决于设备与多个授权策略之一的关联，每个映射到两个状态之一。 比较结果可以追加到设备的活动日志中。