公开(公告)号：US20060058550A1

公开(公告)日：2006-03-16

申请号：US10534334

申请日：2003-11-07

申请人： Thomas Domschke ,  Martin Merger ,  Georg Grobmann ,  Tillmann Faust

发明人： Thomas Domschke ,  Martin Merger ,  Georg Grobmann ,  Tillmann Faust

IPC分类号： C07C69/66

CPC分类号： C07H7/027 ,  Y02P20/127

摘要： The invention relates to a method for producing 2-keto-L-gulonic acid-C4-C10 alkyl ester by esterifying 2-keto-L-gulonic acid (KGS) with an unsaturated, branched or unbranched C4-C10 alcohol. The inventive method is characterized by the fact that an aqueous KGS solution is reacted with a C4-C10 alcohol up to an esterification degree of 20 to 70 percent in a pre-esterification process carried out under acidic catalysis conditions; and the obtained product is dehydrogenated with an unsaturated, branched or unbranched C4-C10 alcohol in a continuous rectification device, whereby the esterification reaction continues, n-butanol preferably being used as the alkyl alcohol. In a preferred embodiment, the aqueous KGS solution is concentrated up to or beyond the limit of solubility prior to the esterification process, preferably by catalyzing a homogeneous or heterogeneous catalyst, especially sulfonic acid, at temperatures of 50 to 120 ° C. In another embodiment, the produced KGS ester is reacted in one or several additional steps so as to obtain L-ascorbic acid.

摘要翻译： 本发明涉及通过酯化2-酮-L-古洛糖酸（KGS）制备2-酮-L-古洛糖酸-C 4 -C 10烷基酯的方法 ）与不饱和，支链或非支链C 4 -C 10醇。 本发明的方法的特征在于，将KGS水溶液与C 4 -C 10 - 醇反应，直到酯化程度为20至70％ 在酸性催化条件下进行酯化过程; 并将得到的产物用连续精馏装置中的不饱和支链或非支链C 4 -C 10醇脱氢，由此继续进行酯化反应，正丁醇优选为 用作烷基醇。 在优选的实施方案中，在酯化过程之前，优选通过在50至120℃的温度下催化均相或多相催化剂，特别是磺酸，将KGS水溶液浓缩至或超过溶解度的极限。在另一个实施方案中 ，所制备的KGS酯在一个或几个附加步骤中反应，以获得L-抗坏血酸。

公开(公告)号：US07091375B2

公开(公告)日：2006-08-15

申请号：US10534334

申请日：2003-11-07

申请人： Thomas Domschke ,  Martin Merger ,  Georg Grossmann ,  Tillmann Faust

发明人： Thomas Domschke ,  Martin Merger ,  Georg Grossmann ,  Tillmann Faust

IPC分类号： C07D305/12

CPC分类号： C07H7/027 ,  Y02P20/127

摘要： The invention relates to a method for producing 2-keto-L-gulonic acid-C4–C10 alkyl ester by esterifying 2-keto-L-gulonic acid (KGS) with an unsaturated, branched or unbranched C4–C10 alcohol. The inventive method is characterized by the fact that an aqueous KGS solution is reacted with a C4–C10 alcohol up to an esterification degree of 20 to 70 percent in a pre-esterification process carried out under acidic catalysis conditions; and the obtained product is dehydrogenated with an unsaturated, branched or unbranched C4–C10 alcohol in a continuous rectification device, whereby the esterification reaction continues, n-butanol preferably being used as the alkyl alcohol. In a preferred embodiment, the aqueous KGS solution is concentrated up to or beyond the limit of solubility prior to the esterification process, preferably by catalyzing a homogeneous or heterogeneous catalyst, especially sulfonic acid, at temperatures of 50 to 120° C. In another embodiment, the produced KGS ester is reacted in one or several additional steps so as to obtain L-ascorbic acid.

摘要翻译： 本发明涉及通过酯化2-酮-L-古洛糖酸（KGS）制备2-酮-L-古洛糖酸-C 4 -C 10烷基酯的方法 ）与不饱和，支链或非支链C 4 -C 10醇。 本发明的方法的特征在于，将KGS水溶液与C 4 -C 10 - 醇反应，直到酯化程度为20至70％ 在酸性催化条件下进行酯化过程; 并将得到的产物用连续精馏装置中的不饱和支链或非支链C 4 -C 10醇脱氢，由此继续进行酯化反应，正丁醇优选为 用作烷基醇。 在优选的实施方案中，在酯化过程之前，优选通过在50至120℃的温度下催化均相或多相催化剂，特别是磺酸，将KGS水溶液浓缩至或超过溶解度的极限。在另一个实施方案中 ，所制备的KGS酯在一个或几个附加步骤中反应，以获得L-抗坏血酸。

公开(公告)号：US20070123717A1

公开(公告)日：2007-05-31

申请号：US10582911

申请日：2004-12-10

申请人： Thomas Domschke ,  Martin Merger ,  Frank Haese ,  Peter Resch ,  Tillmann Faust

发明人： Thomas Domschke ,  Martin Merger ,  Frank Haese ,  Peter Resch ,  Tillmann Faust

IPC分类号： C07D307/62

CPC分类号： C07C67/08 ,  C07H7/02 ,  C07H7/027 ,  C07C69/716

摘要： A method for the production of C1-C10-alkyl 2-keto-L-gulonates by esterification of 2-keto-L-gulonic acid anhydrate with an anhydrous C1-C10-alkyl alcohol in the presence of an acidic homogeneous catalyst in a reactor cascade comprising at least two reactors, one of these reactors being a tubular reactor, without the water forming in the esterification being removed from the reaction space.

摘要翻译： 通过2-酮-L-古洛糖酸无水物与无水C的酯化制备C 1 -C 10 - 烷基2-酮-L-古洛糖化物的方法 在酸性均相催化剂存在下，在包含至少两个反应器的反应器级联中，其中一个反应器是管式反应器，没有 酯化反应中形成的水​​从反应空间中除去。

公开(公告)号：US09206348B2

公开(公告)日：2015-12-08

申请号：US13371880

申请日：2012-02-13

申请人： Sebastian Briechle ,  Tillmann Faust ,  Stephan Freyer ,  Rajan Hollmann ,  Tobias Käppler ,  Bernd Leonhardt ,  Julia Kristiane Schmidt ,  Benjamin Wenzke ,  Foppe Visser

发明人： Sebastian Briechle ,  Tillmann Faust ,  Stephan Freyer ,  Rajan Hollmann ,  Tobias Käppler ,  Bernd Leonhardt ,  Julia Kristiane Schmidt ,  Benjamin Wenzke ,  Foppe Visser

IPC分类号： C09K8/588

CPC分类号： C09K8/588

摘要： A two-stage process for mineral oil production from mineral oil deposits with a deposit temperature of more than 70° C. and a salinity of 20 000 ppm to 350 000 ppm, in which an aqueous formulation comprising at least one glucan with a β-1,3-glycosidically linked main chain, and side groups β-1,6-glycosidically bonded thereto and having a weight-average molecular weight Mw of 1.5*106 to 25*106 g/mol, are injected into a mineral oil deposit through at least one injection borehole and crude oil is withdrawn from the deposit through at least one production borehole. The aqueous formulation is prepared in two stages, by first preparing an aqueous concentrate of the glucan, and diluting the concentrate on site with water to the use concentration.

摘要翻译： 矿物油沉积物的矿物油生产的两阶段工艺，矿物油沉积物的沉积温度高于70℃，盐度为20 000ppm至350 000ppm，其中含有至少一种具有β-葡聚糖的葡聚糖的水性制剂 -1,3糖苷键连接的主链以及重量平均分子量为1.5 * 106〜25 * 106g / mol的重量平均分子量Mw与-1,6-糖基结合的侧基与bgr- 通过至少一个注入井眼沉积，原油通过至少一个生产钻孔从沉积物中排出。 通过首先制备葡聚糖的水性浓缩物，并将水浓缩物在水中稀释至使用浓度，分两步制备水性制剂。

公开(公告)号：US07038058B2

公开(公告)日：2006-05-02

申请号：US10726183

申请日：2003-12-03

申请人： Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Andre Mohry

发明人： Harald Rust ,  Kirsten Burkart ,  Tillmann Faust ,  Jochem Henkelmann ,  Alois Kindler ,  Christian Knoll ,  Andre Mohry

IPC分类号： C07D263/30

CPC分类号： B01D3/141 ,  C07D263/42

摘要： The present invention relates to a process for continuously preparing 5-alkoxy-substituted oxazoles, in particular for continuously preparing 4-methyl-5-alkoxy-substituted oxazoles and also a process for preparing pyridoxine derivatives.

公开(公告)号：US6136251A

公开(公告)日：2000-10-24

申请号：US147855

申请日：1999-03-22

申请人： Karl-Heinz Etzbach ,  Harald Keller ,  Reinhold Leyrer ,  Tillmann Faust ,  Peter Schuhmacher ,  Karl Siemensmeyer

发明人： Karl-Heinz Etzbach ,  Harald Keller ,  Reinhold Leyrer ,  Tillmann Faust ,  Peter Schuhmacher ,  Karl Siemensmeyer

IPC分类号： C09B67/20 ,  C08F2/00 ,  C09B67/00 ,  C09B67/02 ,  C09B69/10 ,  C09K19/00 ,  C09K19/38 ,  B29B9/10

CPC分类号： C09K19/00 ,  C09B67/0097 ,  C09B67/0098 ,  C09K19/38

摘要： A process for preparing pigment particles of defined size and shape comprises treating a sheetlike structure having through openings of defined shape and size with a polymerizable substance or mixture of substances in such a way that the openings are filled, removing any solvent present, polymerizing the substance or substance mixture, and isolating the resulting pigment particles from the openings. The pigments are readily varied in size and shape by variation of the substrate parameters and are useful for the known pigment applications, especially coatings, paints and inks.

摘要翻译： PCT No.PCT / EP97 / 04906 Sec。 371日期1999年3月22日 102（e）1999年3月22日PCT 1997年9月9日PCT公布。 公开号WO98 / 12265 日期1998年3月26日一种制备具有规定尺寸和形状的颜料颗粒的方法包括用可聚合物质或物质混合物处理具有规定形状和尺寸的具有开口的片状结构，使填充开口，除去任何溶剂 存在，使物质或物质混合物聚合，并从所述开口分离得到的颜料颗粒。 通过基板参数的变化，颜料的尺寸和形状容易变化，并且可用于已知的颜料应用，特别是涂料，涂料和油墨。

公开(公告)号：US08574873B2

公开(公告)日：2013-11-05

申请号：US12967099

申请日：2010-12-14

申请人： Jörg Therre ,  Hartwig Voβ ,  Julia Kristiane Schmidt ,  Tillmann Faust ,  Rajan Hollmann

发明人： Jörg Therre ,  Hartwig Voβ ,  Julia Kristiane Schmidt ,  Tillmann Faust ,  Rajan Hollmann

IPC分类号： C12N9/24

CPC分类号： C12P19/04 ,  B01D61/147 ,  B01D63/066 ,  B01D65/02 ,  B01D71/024 ,  B01D71/025 ,  B01D2321/168 ,  B01D2325/022 ,  C08B37/0024

摘要： A process for the preparation of aqueous solutions of glucans having a β-1,3-glycosidically-linked main chain and side groups having a β-1,6-glycosidic bond by fermentation of fungal strains. The fungal strains secrete the glucans into the fermentation broth, in an aqueous culture medium, and the separation of the glucans from the fermentation broth is effected using asymmetrical filter membranes.

摘要翻译： 一种通过发酵真菌菌株制备具有β-1,3-糖苷连接的主链和具有β-1,6-糖苷键的侧基的葡聚糖水溶液的方法。 真菌菌株在水性培养基中将葡聚糖分泌到发酵液中，并且使用不对称的过滤膜从发酵液中分离葡聚糖。

公开(公告)号：US5169759A

公开(公告)日：1992-12-08

申请号：US644609

申请日：1991-01-23

申请人： Tillmann Faust ,  Joachim Meyer ,  Georg Wellinghoff ,  Walter Gosele ,  Christoph Martin ,  Johannes Grimmer

发明人： Tillmann Faust ,  Joachim Meyer ,  Georg Wellinghoff ,  Walter Gosele ,  Christoph Martin ,  Johannes Grimmer

IPC分类号： C07D475/14 ,  C12P17/18 ,  C12P25/00

CPC分类号： C12P25/00

摘要： Riboflavin is removed from fermentation suspensions by them being heated at from 50.degree. to 90.degree. C. for from 1 to 3 hours, than cooled to from 0.degree. to 30.degree. C. over a period of from 1 to 5 hours, and subsequently being centrifuged to give a sediment fraction and liquid fraction in such a way that the sediment fraction contains predominantly riboflavin crystals as solid, and the liquid fraction contains virtually no crystalline riboflavin, and, where appropriate, resuspending the sediment fraction in from 0.5 to 2 parts by volume of water per part by volume of sediment fraction and repeating procedure c.

摘要翻译： 将核黄素从发酵悬浮液中除去，在50〜90℃下加热1〜3小时，冷却至0〜30℃，时间为1〜5小时，随后为 离心分离以得到沉淀物部分和液体部分，使得沉淀物部分主要含有核黄素晶体作为固体，并且液体部分几乎不含结晶核黄素，并且在适当情况下将沉降物组分重悬于0.5至2份中 每部分体积的沉淀物含量的水量和重复程序c。

公开(公告)号：US20120205099A1

公开(公告)日：2012-08-16

申请号：US13371880

申请日：2012-02-13

申请人： Sebastian Briechle ,  Tillmann Faust ,  Stephan Freyer ,  Rajan Hollmann ,  Tobias Käppler ,  Bernd Leonhardt ,  Julia Kristiane Schmidt ,  Benjamin Wenzke ,  Foppe Visser

发明人： Sebastian Briechle ,  Tillmann Faust ,  Stephan Freyer ,  Rajan Hollmann ,  Tobias Käppler ,  Bernd Leonhardt ,  Julia Kristiane Schmidt ,  Benjamin Wenzke ,  Foppe Visser

IPC分类号： E21B43/22

CPC分类号： C09K8/588

摘要： A two-stage process for mineral oil production from mineral oil deposits with a deposit temperature of more than 70° C. and a salinity of 20 000 ppm to 350 000 ppm, in which an aqueous formulation comprising at least one glucan with a β-1,3-glycosidically linked main chain, and side groups β-1,6-glycosidcally bonded thereto and having a weight-average molecular weight Mw of 1.5*106 to 25*106 g/mol, are injected into a mineral oil deposit through at least one injection borehole and crude oil is withdrawn from the deposit through at least one production borehole. The aqueous formulation is prepared in two stages, by first preparing an aqueous concentrate of the glucan, and diluting the concentrate on site with water to the use concentration.

摘要翻译： 矿物油沉积物的矿物油生产的两阶段工艺，矿物油沉积物的沉积温度高于70℃，盐度为20 000ppm至350 000ppm，其中含有至少一种具有β-葡聚糖的葡聚糖的水性制剂 -1,3糖苷键连接的主链以及重量平均分子量Mw为1.5×10 -6〜25×10 6 g / mol的侧链基团与-1,6-糖基结合的基团被注入到矿物油 通过至少一个注入井眼沉积，原油通过至少一个生产钻孔从沉积物中排出。 通过首先制备葡聚糖的水性浓缩物，并将水浓缩物在水中稀释至使用浓度，分两步制备水性制剂。

公开(公告)号：US20110151517A1

公开(公告)日：2011-06-23

申请号：US12967099

申请日：2010-12-14

申请人： Jörg Therre ,  Hartwig Voß ,  Julia Kristiane Schmidt ,  Tillmann Faust ,  Rajan Hollmann

发明人： Jörg Therre ,  Hartwig Voß ,  Julia Kristiane Schmidt ,  Tillmann Faust ,  Rajan Hollmann

IPC分类号： C12P19/44

CPC分类号： C12P19/04 ,  B01D61/147 ,  B01D63/066 ,  B01D65/02 ,  B01D71/024 ,  B01D71/025 ,  B01D2321/168 ,  B01D2325/022 ,  C08B37/0024

摘要： A process for the preparation of aqueous solutions of glucans having a β-1,3-glycosidically-linked main chain and side groups having a β-1,6-glycosidic bond by fermentation of fungal strains. The fungal strains secrete the glucans into the fermentation broth, in an aqueous culture medium, and the separation of the glucans from the fermentation broth is effected using asymmetrical filter membranes.

摘要翻译： 一种通过真菌菌株发酵制备具有β-糖苷连接的主链和具有＆bgr--1,6-糖苷键的侧基的葡聚糖水溶液的方法。 真菌菌株在水性培养基中将葡聚糖分泌到发酵液中，并且使用不对称的过滤膜从发酵液中分离葡聚糖。