公开(公告)号：US20110294876A1

公开(公告)日：2011-12-01

申请号：US13102495

申请日：2011-05-06

申请人： Thomas Küper ,  Heiko Oertling ,  Tilman Grune ,  Matthias Saathoff ,  Martina Herrmann ,  Julia Betke ,  Claudia Gömann ,  Rahim Brodhage ,  Imke Meyer

发明人： Thomas Küper ,  Heiko Oertling ,  Tilman Grune ,  Matthias Saathoff ,  Martina Herrmann ,  Julia Betke ,  Claudia Gömann ,  Rahim Brodhage ,  Imke Meyer

IPC分类号： A61K31/27 ,  C07C271/34 ,  C07D317/58 ,  A61K8/37 ,  A61Q17/04 ,  A61P17/00 ,  A61P17/18 ,  A61P5/48 ,  A61Q19/08 ,  C07C271/38 ,  A61K31/343

CPC分类号： C07C271/34 ,  A23G3/36 ,  A23G4/06 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/00 ,  A61K8/42 ,  A61K8/4973 ,  A61K2800/522 ,  A61K2800/85 ,  A61K2800/92 ,  A61Q1/02 ,  A61Q17/04 ,  A61Q19/08 ,  C07C271/36 ,  C07C271/38 ,  C07C2601/14 ,  C07C2602/42 ,  C07D307/14 ,  C07D317/58 ,  A23V2200/318

摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of compounds of formula (I) given below, in particular as anti-ageing actives. whereinA denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, whereinR1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms,R2 denotes an organic radical having 1 to 14 carbon atoms,and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring. The invention further relates to corresponding methods and to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) and one or more further anti-ageing actives. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition and to certain novel compounds of formula (I).

摘要翻译： 本发明涉及以下给出的式（I）化合物的化妆品，皮肤病学或治疗用途，特别是作为抗衰老活性物质。 其中A表示其中X，Y和Z彼此独立地表示氢，C1-C4-烷基或C2-C4-烯基，其中任选地两个基团X，Y和Z彼此共价键合，形成双环 在这种双环体系中，基团X，Y和Z中的两个一起优选形成具有1至4个碳原子的基团，优选地具有1至3个碳原子的烃基，B表示NR1R2，其中R1表示氢或 具有1至14个碳原子的有机基团，R 2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选B为3至8元环。 本发明还涉及相应的方法以及包含一种或多种式（I）化合物和一种或多种其它抗衰老活性物质的组合物和化妆品，皮肤病学或药物制剂（组合物）。 本发明还涉及作为药物的式（I）化合物，其用于制备药物组合物和某些新的式（I）化合物的用途。