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公开(公告)号:US20130108641A1
公开(公告)日:2013-05-02
申请号:US13611789
申请日:2012-09-12
申请人: Nicolas Baurin , Francis Blanche , Béatrice Cameron , Tarik Dabdoubi , Jeremy Fordham , Dorothea Kominos , Jacintha Norohna , Tim Soos
发明人: Nicolas Baurin , Francis Blanche , Béatrice Cameron , Tarik Dabdoubi , Jeremy Fordham , Dorothea Kominos , Jacintha Norohna , Tim Soos
IPC分类号: C07K16/28 , A61K31/439 , A61K31/56 , A61K38/13 , A61K39/395 , A61K31/519
CPC分类号: C07K16/2866 , A61K31/439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K39/3955 , A61K2039/505 , C07K16/2878 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要: The invention provides antibodies that specifically bind to human GITR (hGITR) with high affinity and antagonize the binding of hGITRL to hGITR. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-GITR antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies of the invention to detect hGITR or to modulate hGITR activity, either in vitro or in vivo, are also provided by the invention.
摘要翻译: 本发明提供以高亲和力特异性结合人GITR(hGITR)的抗体,并拮抗hGITRL与hGITR的结合。 本发明还提供药物组合物,以及编码抗GITR抗体的核酸,重组表达载体和用于制备此类抗体的宿主细胞或其片段。 本发明还提供了使用本发明的抗体来检测hGITR或调节体外或体内的hGITR活性的方法。