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1.发明申请Dual Variable Region Antibody-Like Binding Proteins Having Cross-Over Binding Region Orientation 有权具有交叉结合区域取向的双变区抗体样结合蛋白公开(公告)号：US20140056895A1
公开(公告)日：2014-02-27
申请号：US13804965
申请日：2013-03-14
申请人： Nicolas Baurin , Chirstian Biel , Carsten Corvey , Christian Lange , Danxi Li , Vincent Mikol , Anke Steinmetz , Ercole Rao
发明人： Nicolas Baurin , Chirstian Biel , Carsten Corvey , Christian Lange , Danxi Li , Vincent Mikol , Anke Steinmetz , Ercole Rao
CPC分类号： C07K16/46 , C07K16/00 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K16/461 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.
摘要翻译： 本发明提供了包含形成四个抗原结合位点的四条多肽链的抗体样结合蛋白，其中形成抗体样结合蛋白的每对多肽具有交叉取向的双重可变结构域。 本发明还提供了制备这种抗原样结合蛋白的方法。
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公开(公告)号：US20130108641A1
公开(公告)日：2013-05-02
申请号：US13611789
申请日：2012-09-12
申请人： Nicolas Baurin , Francis Blanche , Béatrice Cameron , Tarik Dabdoubi , Jeremy Fordham , Dorothea Kominos , Jacintha Norohna , Tim Soos
发明人： Nicolas Baurin , Francis Blanche , Béatrice Cameron , Tarik Dabdoubi , Jeremy Fordham , Dorothea Kominos , Jacintha Norohna , Tim Soos
IPC分类号： C07K16/28 , A61K31/439 , A61K31/56 , A61K38/13 , A61K39/395 , A61K31/519
CPC分类号： C07K16/2866 , A61K31/439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K39/3955 , A61K2039/505 , C07K16/2878 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The invention provides antibodies that specifically bind to human GITR (hGITR) with high affinity and antagonize the binding of hGITRL to hGITR. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-GITR antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies of the invention to detect hGITR or to modulate hGITR activity, either in vitro or in vivo, are also provided by the invention.
摘要翻译： 本发明提供以高亲和力特异性结合人GITR（hGITR）的抗体，并拮抗hGITRL与hGITR的结合。 本发明还提供药物组合物，以及编码抗GITR抗体的核酸，重组表达载体和用于制备此类抗体的宿主细胞或其片段。 本发明还提供了使用本发明的抗体来检测hGITR或调节体外或体内的hGITR活性的方法。
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3.发明授权Antagonist antibodies and their fab fragments against GPVI and uses thereof 有权拮抗剂抗体及其针对GPVI的Fab片段及其用途公开(公告)号：US08852593B2
公开(公告)日：2014-10-07
申请号：US13515650
申请日：2010-12-17
申请人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Carsten Corvey , Tarik Dabdoubi , Christian Engel , Peter Florian , Ingo Focken , Katja Kroll , Jochen Kruip , Christian Lange , Thomas Langer , Martin Lorenz , Vincent Mikol , Ercole Rao , Peter Wonerow
发明人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Carsten Corvey , Tarik Dabdoubi , Christian Engel , Peter Florian , Ingo Focken , Katja Kroll , Jochen Kruip , Christian Lange , Thomas Langer , Martin Lorenz , Vincent Mikol , Ercole Rao , Peter Wonerow
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K1/1075 , C07K16/2803 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion phenotype. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab. The invention concerns a method for prevention of platelet activation when an anti-GP VI Fab is used.
摘要翻译： 本发明公开了特异性结合人血小板膜蛋白Glycoprotein VI（GPVI）及其单价片段或衍生物的新型抗体。 本发明的抗体是来自杂交瘤克隆390的抗体及其能诱导GPVI消耗表型的片段抗体。 这些抗体和Fab片段能够阻断胶原结合，从而阻止胶原的血小板活化。 本发明还涉及用于产生所公开的抗体和Fab片段的杂交瘤克隆和表达质粒。 本发明还涉及一价抗体片段用于制备用于治疗血栓形成和其它血管疾病的研究，诊断和免疫治疗剂的用途。 本发明还涉及在C-末端具有分子的Fab，以及使用这种修饰的Fab预防用抗体识别Fab的方法。 本发明涉及当使用抗GP VI Fab时预防血小板活化的方法。
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4.发明申请Dual Variable Region Antibody-Like Binding Proteins Having Cross-Over Binding Region Orientation 审中-公开具有交叉结合区域取向的双变区抗体样结合蛋白公开(公告)号：US20130345404A1
公开(公告)日：2013-12-26
申请号：US13826217
申请日：2013-03-14
申请人： Nicolas Baurin , Chirstian Biel , Carsten Corvey , Christian Lange , Danxi Li , Vincent Mikol , Anke Steinmetz , Ercole Rao
发明人： Nicolas Baurin , Chirstian Biel , Carsten Corvey , Christian Lange , Danxi Li , Vincent Mikol , Anke Steinmetz , Ercole Rao
IPC分类号： C07K16/46
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.
摘要翻译： 本发明提供了包含形成四个抗原结合位点的四条多肽链的抗体样结合蛋白，其中形成抗体样结合蛋白的每对多肽具有交叉取向的双重可变结构域。 本发明还提供了制备这种抗原样结合蛋白的方法。
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公开(公告)号：US20110027266A1
公开(公告)日：2011-02-03
申请号：US12675799
申请日：2008-08-27
申请人： Renata Lee , Vincent Mikol , Elizabeth Allen , Norman Ruetsch , Beatrice Cameron , Thomas Oligino , Nicolas Baurin
发明人： Renata Lee , Vincent Mikol , Elizabeth Allen , Norman Ruetsch , Beatrice Cameron , Thomas Oligino , Nicolas Baurin
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/28 , C07K16/2896 , C07K2317/24 , C07K2317/33 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , G06F19/12
摘要： The present invention relates to humanized antibodies that specifically bind to CXCR5 and can, for example, inhibit CXCR5 function. The invention also includes uses of the antibodies to treat or prevent CXCR5 related diseases or disorders.
摘要翻译： 本发明涉及特异性结合CXCR5并可以例如抑制CXCR5功能的人源化抗体。 本发明还包括抗体治疗或预防CXCR5相关疾病或病症的用途。
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6.发明授权Peptide or peptide complex binding to ALPHA2 integrin and methods and uses involving the same 有权肽或肽复合物与ALPHA2整联蛋白结合，涉及相同的方法和用途公开(公告)号：US09234039B2
公开(公告)日：2016-01-12
申请号：US13819620
申请日：2011-08-30
申请人： Carsten Corvey , Horst Blum , Béatrice Cameron , Tarik Dabdoubi , Stephanie Decary , Nicolas Baurin , David Papin , Christian Lange
发明人： Carsten Corvey , Horst Blum , Béatrice Cameron , Tarik Dabdoubi , Stephanie Decary , Nicolas Baurin , David Papin , Christian Lange
IPC分类号： A61K39/00 , A61K39/395 , C07K16/28 , G01N33/68
CPC分类号： C07K16/2842 , C07K16/2839 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/6857 , G01N33/6872 , G01N2333/70546 , G01N2333/7055
摘要： The present invention relates to a peptide or peptide complex binding to α2 integrin, to one or more nucleic acid(s) coding for the peptide or peptide complex, a recombinant cell producing the peptide or peptide complex, a method for producing the peptide or peptide complex, a pharmaceutical composition comprising the peptide or peptide complex or the nucleic acid(s) for use as a medicament, a method for detecting α2 integrin and a screening method.
摘要翻译： 本发明涉及与α2整联蛋白结合的肽或肽复合物，与编码肽或肽复合物的一种或多种核酸，产生肽或肽复合物的重组细胞，产生肽或肽的方法 复合物，包含肽或肽复合物或用作药物的核酸的药物组合物，检测α2整联蛋白的方法和筛选方法。
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7.发明授权Humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide 有权对原始原纤维形式的β-淀粉样蛋白肽特异的人源化抗体公开(公告)号：US08614299B2
公开(公告)日：2013-12-24
申请号：US13319710
申请日：2010-05-11
申请人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Marc Duchesne , Vincent Mikol , Souad Naimi , Laurent Pradier , Yi Shi
发明人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Marc Duchesne , Vincent Mikol , Souad Naimi , Laurent Pradier , Yi Shi
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , C07H21/04 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/92 , C12N15/63 , C12N2015/8518
摘要： The present application relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, and to the use of said antibodies in the field of Alzheimer's disease.
摘要翻译： 本申请涉及对原始原纤维形式的β-淀粉样蛋白肽特异性的人源化抗体以及所述抗体在阿尔茨海默氏病领域中的应用。
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8.发明授权公开(公告)号：US09221917B2
公开(公告)日：2015-12-29
申请号：US13804965
申请日：2013-03-14
申请人： Nicolas Baurin , Chirstian Biel , Carsten Corvey , Christian Lange , Danxi Li , Vincent Mikol , Anke Steinmetz , Ercole Rao
发明人： Nicolas Baurin , Chirstian Biel , Carsten Corvey , Christian Lange , Danxi Li , Vincent Mikol , Anke Steinmetz , Ercole Rao
CPC分类号： C07K16/46 , C07K16/00 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K16/461 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.
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9.发明授权Dual variable region antibody-like binding proteins having cross-over binding region orientation 有权具有交叉结合区取向的双重可变区抗体样结合蛋白公开(公告)号：US09181349B2
公开(公告)日：2015-11-10
申请号：US13826126
申请日：2013-03-14
申请人： Nicolas Baurin , Chirstian Biel , Carsten Corvey , Christian Lange , Danxi Li , Vincent Mikol , Anke Steinmetz , Ercole Rao
发明人： Nicolas Baurin , Chirstian Biel , Carsten Corvey , Christian Lange , Danxi Li , Vincent Mikol , Anke Steinmetz , Ercole Rao
CPC分类号： C07K16/46 , C07K16/00 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K16/461 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.
摘要翻译： 本发明提供了包含形成四个抗原结合位点的四条多肽链的抗体样结合蛋白，其中形成抗体样结合蛋白的每对多肽具有交叉取向的双重可变结构域。 本发明还提供了制备这种抗原样结合蛋白的方法。
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公开(公告)号：US20110150903A1
公开(公告)日：2011-06-23
申请号：US13002845
申请日：2009-07-07
申请人： Nicolas Baurin , Pierre-Francois Berne , Francis Blanche , Francoise Bono , Beatrice Cameron , Tarik Dabdoubi , Corentin Herbert , Vincent Mikol , Elisabeth Remy
发明人： Nicolas Baurin , Pierre-Francois Berne , Francis Blanche , Francoise Bono , Beatrice Cameron , Tarik Dabdoubi , Corentin Herbert , Vincent Mikol , Elisabeth Remy
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/303 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention relates to FGF-R4 receptor-specific antagonist molecules enabling the inhibition of the activity of said receptor. Said antagonists are, particularly, FGF-R4-specific antibodies enabling the inhibition of the activity of said receptor. The present invention also relates to the therapeutic use of said antibodies, particularly in the field of angiogenesis and in the treatment of certain types of cancer.
摘要翻译： 本发明涉及能够抑制所述受体的活性的FGF-R4受体特异性拮抗剂分子。 所述拮抗剂尤其是能够抑制所述受体活性的FGF-R4特异性抗体。 本发明还涉及所述抗体的治疗用途，特别是在血管生成领域和治疗某些类型的癌症中。
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