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公开(公告)号：US20160355514A1
公开(公告)日：2016-12-08
申请号：US15243289
申请日：2016-08-22
Applicant: Kenneth W. BAIR , Timm R. BAUMEISTER , Peter DRAGOVICH , Francis GOSSELIN , Po-Wai YUEN , Mark ZAK , Xiaozhang ZHENG
Inventor： Kenneth W. BAIR , Timm R. BAUMEISTER , Peter DRAGOVICH , Francis GOSSELIN , Po-Wai YUEN , Mark ZAK , Xiaozhang ZHENG
IPC: C07D471/04 , C07D491/048 , C07D495/04 , C07D487/04
CPC classification number: C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
Abstract: Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
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公开(公告)号：US09458172B2
公开(公告)日：2016-10-04
申请号：US14382123
申请日：2013-03-01
Applicant: Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
Inventor： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
IPC: C07D498/00 , C07D413/00 , C07D487/00 , C07D401/00 , C07D221/02 , C07D471/02 , A61K31/4965 , A61K31/519 , A61K31/44 , A61K31/47 , C07D495/04 , C07D471/04 , C07D491/048 , A61K45/06 , A61K31/455 , A61K31/706 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D487/04
CPC classification number: C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
Abstract: Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
Abstract translation: 公开了某些吡啶基和嘧啶基亚砜和砜化合物，包含这些化合物的药物组合物和使用这些化合物的治疗方法。
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公开(公告)号：US20150175621A1
公开(公告)日：2015-06-25
申请号：US14382123
申请日：2013-03-01
Applicant: Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
Inventor： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
IPC: C07D495/04 , A61K31/444 , C07D487/04 , A61K31/519 , A61K45/06 , A61K31/506 , A61K31/4545 , A61K31/5377 , A61K31/496 , C07D471/04 , C07D491/048
CPC classification number: C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
Abstract: Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
Abstract translation: 公开了某些吡啶基和嘧啶基亚砜和砜化合物，包含这些化合物的药物组合物和使用这些化合物的治疗方法。
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Patent Agency Ranking
公开(公告)号：US20130273034A1
公开(公告)日：2013-10-17
申请号：US13820496
申请日：2011-09-02
Applicant: Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
Inventor： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC: C07D401/12 , C07D213/40 , A61K31/4406 , A61K45/06 , C07D471/04 , A61K31/437 , C07D213/74 , A61K31/44 , A61K31/4545 , A61K31/5377
CPC classification number: C07D401/12 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07C317/42 , C07D213/40 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/84 , C07D471/04
Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
Abstract translation: 本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。 本发明的说明性化合物如下所示：
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公开(公告)号：US20170216262A1
公开(公告)日：2017-08-03
申请号：US15473110
申请日：2017-03-29
Applicant: Kenneth W. BAIR , Timm R. BAUMEISTER , Peter DRAGOVICH , Xiongcai LIU , Snahel PATEL , Po-Wai YUEN , Mark ZAK , Guiling ZHAO , Yamin ZHANG , Xiaozhang ZHENG
Inventor： Kenneth W. BAIR , Timm R. BAUMEISTER , Peter DRAGOVICH , Xiongcai LIU , Snahel PATEL , Po-Wai YUEN , Mark ZAK , Guiling ZHAO , Yamin ZHANG , Xiaozhang ZHENG
IPC: A61K31/438 , C07D471/04 , C07D495/04 , C07D487/04 , A61K31/519 , C07D491/048 , A61K31/496 , A61K31/4545 , A61K31/444 , A61K31/497 , A61K31/5377 , A61K31/513 , A61K31/541 , A61K31/506 , A61K31/501 , C07D519/00 , A61K45/06
CPC classification number: C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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6.发明授权Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) 有权用于抑制烟酰胺磷酸核糖基转移酶（NAMPT）的哌啶衍生物和组合物公开(公告)号：US09555039B2
公开(公告)日：2017-01-31
申请号：US14115849
申请日：2011-09-02
Applicant: Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Judith D. Kuntz , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
Inventor： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Judith D. Kuntz , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
IPC: A61K31/44 , A01N43/42 , A61K31/5377 , C07D215/48 , C07D471/04 , C07D513/04 , C07D519/00 , A61K31/4545 , A61K45/06
CPC classification number: C07D519/00 , A61K31/437 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D215/48 , C07D471/04 , C07D495/04 , C07D513/04
Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)
Abstract translation: 本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。 本发明的说明性化合物如下所示：式（I）
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公开(公告)号：US20150104384A1
公开(公告)日：2015-04-16
申请号：US14382141
申请日：2013-03-01
Applicant: Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zao , Xiaozhang Zheng , Po-Wai Yuen
Inventor： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zao , Xiaozhang Zheng , Po-Wai Yuen
IPC: C07D519/00 , A61K31/454 , A61K31/5386 , C07D491/048 , A61K31/4545 , A61K45/06 , C07D471/04 , C07D495/04 , A61K31/496 , A61K31/5025 , A61K31/46 , A61K31/551 , C07D487/04 , A61K31/5377
Abstract: The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
Abstract translation: 本发明涉及某些酰氨基 - 苄基亚砜和砜化合物，包含这些化合物的药物组合物和使用这些化合物的治疗方法。
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公开(公告)号：US20140294805A1
公开(公告)日：2014-10-02
申请号：US13820497
申请日：2011-09-02
Applicant: Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
Inventor： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC: C07D495/04 , A61K31/437 , C07D471/04 , C07D487/04 , A61K31/519 , A61K31/55 , C07D491/048 , A61K31/4355 , A61K31/4365 , A61K31/496 , A61K31/5377 , A61K45/06 , A61K31/497
CPC classification number: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
Abstract translation: 本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。 本发明的说明性化合物如下所示：
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