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公开(公告)号：US20150104384A1
公开(公告)日：2015-04-16
申请号：US14382141
申请日：2013-03-01
申请人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zao , Xiaozhang Zheng , Po-Wai Yuen
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zao , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号： C07D519/00 , A61K31/454 , A61K31/5386 , C07D491/048 , A61K31/4545 , A61K45/06 , C07D471/04 , C07D495/04 , A61K31/496 , A61K31/5025 , A61K31/46 , A61K31/551 , C07D487/04 , A61K31/5377
摘要： The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
摘要翻译： 本发明涉及某些酰氨基 - 苄基亚砜和砜化合物，包含这些化合物的药物组合物和使用这些化合物的治疗方法。
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公开(公告)号：US20140294805A1
公开(公告)日：2014-10-02
申请号：US13820497
申请日：2011-09-02
申请人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： C07D495/04 , A61K31/437 , C07D471/04 , C07D487/04 , A61K31/519 , A61K31/55 , C07D491/048 , A61K31/4355 , A61K31/4365 , A61K31/496 , A61K31/5377 , A61K45/06 , A61K31/497
CPC分类号： A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
摘要翻译： 本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。 本发明的说明性化合物如下所示：
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公开(公告)号：US09458172B2
公开(公告)日：2016-10-04
申请号：US14382123
申请日：2013-03-01
申请人： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
发明人： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
IPC分类号： C07D498/00 , C07D413/00 , C07D487/00 , C07D401/00 , C07D221/02 , C07D471/02 , A61K31/4965 , A61K31/519 , A61K31/44 , A61K31/47 , C07D495/04 , C07D471/04 , C07D491/048 , A61K45/06 , A61K31/455 , A61K31/706 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D487/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
摘要： Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
摘要翻译： 公开了某些吡啶基和嘧啶基亚砜和砜化合物，包含这些化合物的药物组合物和使用这些化合物的治疗方法。
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公开(公告)号：US20150175621A1
公开(公告)日：2015-06-25
申请号：US14382123
申请日：2013-03-01
申请人： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
发明人： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
IPC分类号： C07D495/04 , A61K31/444 , C07D487/04 , A61K31/519 , A61K45/06 , A61K31/506 , A61K31/4545 , A61K31/5377 , A61K31/496 , C07D471/04 , C07D491/048
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
摘要： Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
摘要翻译： 公开了某些吡啶基和嘧啶基亚砜和砜化合物，包含这些化合物的药物组合物和使用这些化合物的治疗方法。
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5.发明授权公开(公告)号：US08461328B2
公开(公告)日：2013-06-11
申请号：US13004808
申请日：2011-01-11
申请人： Srinivasan Babu , Phillippe Bergeron , Peter Dragovich , Hazel Joan Dyke , Paul Gibbons , Stefan Gradl , Emily Hanan , Christopher Hurley , Tony Johnson , Michael Koehler , Janusz Kulagowski , Sharada Labadie , Joseph Lyssikatos , Rohan Mendonca , Rebecca Pulk , Stuart Ward , Bohdan Waszkowycz , Mark Zak
发明人： Srinivasan Babu , Phillippe Bergeron , Peter Dragovich , Hazel Joan Dyke , Paul Gibbons , Stefan Gradl , Emily Hanan , Christopher Hurley , Tony Johnson , Michael Koehler , Janusz Kulagowski , Sharada Labadie , Joseph Lyssikatos , Rohan Mendonca , Rebecca Pulk , Stuart Ward , Bohdan Waszkowycz , Mark Zak
IPC分类号： A61P11/06 , A61P17/06 , A61P19/02 , A61P37/06 , C07D413/14 , C07D471/14
CPC分类号： C07D471/14 , C07D487/10
摘要： The invention provides novel compounds of formula I having the general formula: wherein R1, R2, R3, X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
摘要翻译： 本发明提供具有以下通式的新颖的式I化合物：其中R1，R2，R3，X和Y如本文所述。 因此，化合物可以以药学上可接受的组合物提供，并用于治疗免疫学或过度增殖性疾病。
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6.发明申请公开(公告)号：US20110201593A1
公开(公告)日：2011-08-18
申请号：US13004808
申请日：2011-01-11
申请人： Srinivasan Babu , Phillippe Bergeron , Peter Dragovich , Hazel Joan Dyke , Paul Gibbons , Stefan Gradl , Emily Hanan , Christopher Hurley , Tony Johnson , Michael Koehler , Janusz Kulagowski , Sharada Labadie , Joseph Lyssikatos , Rohan Mendonca , Rebecca Pulk , Stuart Ward , Bohdan Waszkowycz , Mark Zak
发明人： Srinivasan Babu , Phillippe Bergeron , Peter Dragovich , Hazel Joan Dyke , Paul Gibbons , Stefan Gradl , Emily Hanan , Christopher Hurley , Tony Johnson , Michael Koehler , Janusz Kulagowski , Sharada Labadie , Joseph Lyssikatos , Rohan Mendonca , Rebecca Pulk , Stuart Ward , Bohdan Waszkowycz , Mark Zak
IPC分类号： A61K31/397 , C07D471/14 , A61K31/437 , C07D413/14 , A61K31/5377 , A61K31/496 , A61K31/55 , A61K31/506 , A61P19/02 , A61P17/06 , A61P37/06 , A61P11/06
CPC分类号： C07D471/14 , C07D487/10
摘要： The invention provides novel compounds of formula I having the general formula: wherein R1, R2, R3, X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
摘要翻译： 本发明提供具有以下通式的新颖的式I化合物：其中R1，R2，R3，X和Y如本文所述。 因此，化合物可以以药学上可接受的组合物提供，并用于治疗免疫学或过度增殖性疾病。
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公开(公告)号：US09822129B2
公开(公告)日：2017-11-21
申请号：US14382210
申请日：2013-03-01
申请人： GENENTECH,INC. , FORMA TM, LLC , Po-Wai Yuen
发明人： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC分类号： C07D519/00 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , A61K31/438 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06
CPC分类号： C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
摘要： Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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![[1,2,4]Thiadiazin-3-yl acetic acid compound and methods of making the acetic acid compound](/abs-image/US/2012/07/17/US08222404B2/abs.jpg.150x150.jpg)
8.发明授权[1,2,4]Thiadiazin-3-yl acetic acid compound and methods of making the acetic acid compound 有权[1,2,4]噻二嗪-3-基乙酸化合物和制备乙酸化合物的方法公开(公告)号：US08222404B2
公开(公告)日：2012-07-17
申请号：US13349705
申请日：2012-01-13
IPC分类号： C07D513/04
CPC分类号： C07D513/04 , C07D417/04
摘要： The invention is directed to a [7-methanesulfonylamino-methyl)-1,1-dioxo-1,4-dihydro-1λ6-thieno[2,3-e][1,2,4]thiadiazin-3-yl]-acetic acid compound and to methods of making the same.
摘要翻译： 本发明涉及[7-甲磺酰基氨基 - 甲基] -1,1-二氧代-1,4-二氢-1λ6-噻吩并[2,3-e] [1,2,4]噻二嗪-3-基] 乙酸化合物及其制备方法。
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公开(公告)号：US20100034773A1
公开(公告)日：2010-02-11
申请号：US12061499
申请日：2008-04-02
申请人： Chinh V. Tran , Frank Ruebsam , Douglas E. Murphy , Peter Dragovich , Yuefen Zhou , Lijian Chen , David Kucera , Fritz Blatter , Martin Viertelhaus
发明人： Chinh V. Tran , Frank Ruebsam , Douglas E. Murphy , Peter Dragovich , Yuefen Zhou , Lijian Chen , David Kucera , Fritz Blatter , Martin Viertelhaus
IPC分类号： A61K38/21 , C12N7/04 , A61P31/12 , A61K31/542 , A61K31/5415 , C07D285/26 , C07D279/16
CPC分类号： C07D417/04 , A61K31/5415 , A61K31/549 , A61K45/06 , C07D417/14 , C07D491/18 , C07D513/04
摘要： The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译： 本发明涉及5,6-二氢-1H-吡啶-2-酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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公开(公告)号：US20080227774A1
公开(公告)日：2008-09-18
申请号：US12048933
申请日：2008-03-14
申请人： Frank Ruebsam , Peter Dragovich
发明人： Frank Ruebsam , Peter Dragovich
IPC分类号： A61K31/549 , C07D417/04 , C12N7/06 , A61P31/12
CPC分类号： C07D417/04
摘要： The invention is directed to 5,5-disubstituted-indolizinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译： 本发明涉及5,5-二取代的中氮茚酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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