公开(公告)号：US07792866B2

公开(公告)日：2010-09-07

申请号：US10648752

申请日：2003-08-25

申请人： Robbert C. Van Der Linden ,  Stefan Tobias Mayr ,  Brain S. Vickery

发明人： Robbert C. Van Der Linden ,  Stefan Tobias Mayr ,  Brain S. Vickery

IPC分类号： G06F7/00 ,  G06F17/30

CPC分类号： G06F17/30595

摘要： A method and system for querying a structured document stored in its native format in a database, where the structured document includes a plurality of nodes that form a hierarchical node tree, is disclosed. The method includes providing at least one child pointer in each of the plurality of nodes, where the at least one child pointer points to a corresponding child node of the plurality of nodes, and storing a hint in each of the at least one child pointers. The hint is then utilized to navigate the hierarchical node tree during query evaluation.

摘要翻译： 公开了一种在数据库中查询以其本机格式存储的结构化文档的方法和系统，其中结构化文档包括形成分层结构树的多个节点。 所述方法包括在所述多个节点中的每一个中提供至少一个子指针，其中所述至少一个子指针指向所述多个节点中的相应子节点，并且在所述至少一个子指针的每一个中存储提示。 然后在查询评估期间利用提示来导航分层节点树。

公开(公告)号：US20130065791A1

公开(公告)日：2013-03-14

申请号：US13698895

申请日：2011-05-19

申请人： André Rosenthal ,  Bernd Hinzmann ,  Tobias Mayr ,  Hans-Peter Adams

发明人： André Rosenthal ,  Bernd Hinzmann ,  Tobias Mayr ,  Hans-Peter Adams

IPC分类号： C40B30/04 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q1/6834 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

摘要： The invention pertains to a method for early detection and screening of colorectal cancer in human subjects based on RNA isolated from blood obtained from said subject. According to the invention, the abundance of at least 3, 5, 8, 30, 60, 102, 202, 55, 1002 or 1002 RNAs listed in tables 1 to 13 is measured. Using the invention, an accurate and noninvasive screening and diagnosis tool for colorectal cancer is provided with a sensitivity of at least 80% and a specificity of 85% that has high clinical utility and the potential for broad adoption.

摘要翻译： 本发明涉及一种基于从所述受试者获得的血液中分离的RNA来早期检测和筛选人类受试者的结肠直肠癌的方法。 根据本发明，测量表1至13中列出的至少3,5,8,30,60,102,202,55,1002或1002个RNA的丰度。 使用本发明，提供用于结肠直肠癌的精确和无创的筛查和诊断工具，具有至少80％的敏感性和85％的特异性，具有高临床效用和广泛采用的潜力。

公开(公告)号：US20110287957A1

公开(公告)日：2011-11-24

申请号：US13111514

申请日：2011-05-19

申请人： Andre Rosenthal ,  Bernd Hinzmann ,  Tobias Mayr ,  Hans-Peter Adams

发明人： Andre Rosenthal ,  Bernd Hinzmann ,  Tobias Mayr ,  Hans-Peter Adams

IPC分类号： C40B30/04 ,  C12Q1/68 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q1/6834 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

摘要： The invention pertains to a method for early detection and screening of colorectal cancer in human subjects based on RNA isolated from blood obtained from said subject. According to the invention, the expression of at least 3, 5, 8, 30, 60, 102, 202, 55, 1002 or 1002 RNAs listed in Tables 1-15 are measured. Using the invention, an accurate and noninvasive screening and diagnosis tool for colorectal cancer is provided with a sensitivity of at least 80% and a specificity of 85% that has high clinical utility and the potential for broad adoption.

摘要翻译： 本发明涉及一种基于从所述受试者获得的血液中分离的RNA来早期检测和筛选人类受试者的结肠直肠癌的方法。 根据本发明，测量表1-15中列出的至少3,5,8,30,60,102,202,55,1002或1002个RNA的表达。 使用本发明，提供用于结肠直肠癌的精确和无创的筛查和诊断工具，具有至少80％的敏感性和85％的特异性，具有高临床效用和广泛采用的潜力。

公开(公告)号：US20130143210A1

公开(公告)日：2013-06-06

申请号：US13503798

申请日：2010-10-28

申请人： Fabian Model ,  Tamas Rujan ,  Tobias Mayr ,  Andre Rosenthal

发明人： Fabian Model ,  Tamas Rujan ,  Tobias Mayr ,  Andre Rosenthal

IPC分类号： C12Q1/68

CPC分类号： C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156

摘要： The invention relates to a method for determining prognosis of subjects with ovarian carcinoma using a biological sample comprising genomic tumor DNA isolated from the subject. According to the invention, the method comprises the steps of: determining the methylation status of a CpG dinucleotide in a target sequence that is selected from the group consisting of the target sequences as referred to by name in Table 1 in a biological sample isolated from a subject; and deducing from the determined methylation status of the target sequence the prognosis of subject with ovarian carcinoma. The improved prognosis determination of the subject with ovarian carcinoma enables the improved treatment of the said patient.

摘要翻译： 本发明涉及使用包含从受试者分离的基因组肿瘤DNA的生物样品来确定卵巢癌患者预后的方法。 根据本发明，所述方法包括以下步骤：确定选自下述靶序列中的CpG二核苷酸的甲基化状态，所述靶序列选自由表1所示的靶序列分离自 学科; 并从目标序列确定的甲基化状态推断卵巢癌患者的预后。 用卵巢癌改善预后的方法可以改善对所述患者的治疗。

公开(公告)号：US20090269775A1

公开(公告)日：2009-10-29

申请号：US12519216

申请日：2007-11-01

申请人： Bernd Hinzmann ,  Hans-Peter Adams ,  Tobias Mayr ,  Djork-Arne Clevert

发明人： Bernd Hinzmann ,  Hans-Peter Adams ,  Tobias Mayr ,  Djork-Arne Clevert

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C40B40/08

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The invention relates to the use of gene expression profiles for predicting the probability of recurrence or metastases to develop in remote organs of patients from which a primary colon carcinoma has been removed.

摘要翻译： 本发明涉及使用基因表达谱来预测已经去除原发性结肠癌的患者的远端器官中发生复发或转移的可能性。