公开(公告)号：US08501111B2

公开(公告)日：2013-08-06

申请号：US13447165

申请日：2012-04-14

Applicant: Tom Cheng Xu

Inventor： Tom Cheng Xu

IPC: G01N1/00

CPC classification number: C12Q1/28 ,  G01N33/521 ,  G01N33/523 ,  G01N33/525 ,  G01N33/526

Abstract: A fast acting sensor designed to accommodate an aqueous analyte-containing sample having a volume of less than one microliter and that can be used to quantify the amount and concentration of such analyte in the sample through light reflectance or fiber-optic light reflectance. The sensor includes a storage chamber, a capillary passage, and a reaction membrane. The storage chamber acts to collect the sample and to secure such sample while it undergoes detection. The capillary passage acts to direct the sample over the reaction membrane and controls the diffusion of the sample in the storage chamber. The reaction membrane contains all of the chemicals and enzymes needed to cause a color-change reaction when contacted with the sample. The amount of analyte can be determined by light reflectance intensity with an optical measurement instrument.

Abstract translation: 一种速效传感器，其设计用于容纳体积小于1微升的含水分析物样品，可用于通过光反射率或光纤光反射率定量样品中此类分析物的量和浓度。 传感器包括储存室，毛细通道和反应膜。 储存室用于收集样品并固定样品，同时进行检测。 毛细管通道用于将样品引导到反应膜上并控制样品在储存室中的扩散。 反应膜含有当与样品接触时引起变色反应所需的所有化学物质和酶。 分析物的量可以通过光学测量仪器的光反射强度来确定。

公开(公告)号：US20130102065A1

公开(公告)日：2013-04-25

申请号：US13447165

申请日：2012-04-14

Applicant: Tom Cheng Xu

Inventor： Tom Cheng Xu

IPC: C12Q1/28

CPC classification number: C12Q1/28 ,  G01N33/521 ,  G01N33/523 ,  G01N33/525 ,  G01N33/526

Abstract: A fast acting sensor designed to accommodate an aqueous analyte-containing sample having a volume of less than one microliter and that can be used to quantify the amount and concentration of such analyte in the sample through light reflectance or fiber-optic light reflectance. The sensor includes a storage chamber, a capillary passage, and a reaction membrane. The storage chamber acts to collect the sample and to secure such sample while it undergoes detection. The capillary passage acts to direct the sample over the reaction membrane and controls the diffusion of the sample in the storage chamber. The reaction membrane contains all of the chemicals and enzymes needed to cause a color-change reaction when contacted with the sample. The amount of analyte can be determined by light reflectance intensity with an optical measurement instrument.

Abstract translation: 一种速效传感器，其设计用于容纳体积小于1微升的含水分析物样品，可用于通过光反射率或光纤光反射率定量样品中此类分析物的量和浓度。 传感器包括储存室，毛细通道和反应膜。 储存室用于收集样品并固定样品，同时进行检测。 毛细管通道用于将样品引导到反应膜上并控制样品在储存室中的扩散。 反应膜含有当与样品接触时引起变色反应所需的所有化学物质和酶。 分析物的量可以通过光学测量仪器的光反射强度来确定。

公开(公告)号：US20110053192A1

公开(公告)日：2011-03-03

申请号：US12943001

申请日：2010-11-10

Applicant: Tom Cheng Xu

Inventor： Tom Cheng Xu

IPC: C12Q1/28 ,  C12Q1/52 ,  C12Q1/50 ,  C12Q1/62 ,  C12Q1/60 ,  C12Q1/54

CPC classification number: G01N33/558 ,  G01N33/582

Abstract: Disclosed herein is a dry fluorescence biosensor strip for rapid detection of a target analyte present in bodily fluids. The dry fluorescence biosensor strip comprises a sample receptacle and a dry detection membrane. The sample receptacle receives a sample of one of the bodily fluids. The dry detection membrane detects presence of the target analyte in the received sample based on fluorescence induced on the dry detection membrane. Fluorescent signals are emitted from the dry detection membrane on induction of fluorescence. A fluorometer quantifies measurable properties of the target analyte based on the emitted fluorescent signals. The dry fluorescence biosensor strip may further comprise a filtration membrane for filtering the received sample. The filtered sample migrates from the filtration membrane to the dry detection membrane. The dry detection membrane may then detect presence of the target analyte in the filtered sample.

Abstract translation: 本文公开了用于快速检测存在于体液中的目标分析物的干荧光生物传感器条。 干荧光生物传感器条包括样品容器和干检测膜。 样品容器接收一种体液的样品。 干检测膜基于在干检测膜上诱导的荧光检测接收样品中目标分析物的存在。 在诱导荧光时，从干检测膜发出荧光信号。 荧光计基于发射的荧光信号量化目标分析物的可测量性质。 干荧光生物传感器条可以进一步包括用于过滤所接收的样品的过滤膜。 过滤的样品从过滤膜迁移到干检测膜。 然后，干检测膜可以检测过滤样品中目标分析物的存在。

公开(公告)号：US20100297601A1

公开(公告)日：2010-11-25

申请号：US12454639

申请日：2009-05-21

Applicant: Tom Cheng Xu

Inventor： Tom Cheng Xu

IPC: C12Q1/00

CPC classification number: G01N33/521 ,  G01N33/523 ,  G01N33/525 ,  G01N33/526

Abstract: A sensor designed to accommodate an aqueous analyte sample having a volume of less than 1 μL and can be used to quantify the amount and concentration of such analyte through light reflectance or fiber-optic light reflectance. The sensor includes a reaction membrane and a fixed-volume sample chamber. The fixed-volume sample chamber acts to collect the sample and to secure such sample while it undergoes detection. The reaction membrane contains all of the chemicals and enzymes needed to cause a color reaction when contacted with the sample. The amount of analyte can be determined by light reflectance intensity. The sensor can be used with a meter for in-vitro clinical diagnosis and for patient self-monitoring of a physical condition, such as blood glucose levels.

Abstract translation: 设计用于容纳体积小于1μL的水分析物样品的传感器，可用于通过光反射率或光纤光反射率量化此类分析物的量和浓度。 传感器包括反应膜和固定体积的样品室。 固定体积的样品室用于收集样品并在进行检测时固定样品。 反应膜含有当与样品接触时引起颜色反应所需的所有化学物质和酶。 分析物的量可以通过光反射强度来确定。 该传感器可用于体外临床诊断仪和用于患者身体状态如血糖水平的自我监测的仪表。

公开(公告)号：US20090104635A1

公开(公告)日：2009-04-23

申请号：US12207499

申请日：2008-09-10

Applicant: Tom Cheng Xu

Inventor： Tom Cheng Xu

IPC: C12Q1/62 ,  C12M1/00 ,  C12Q1/00 ,  C12Q1/54 ,  C12N11/00 ,  C12Q1/48 ,  C12Q1/60 ,  C12Q1/28

CPC classification number: G01N33/558 ,  G01N33/582

Abstract: Disclosed herein is a dry fluorescence biosensor strip for rapid detection of a target analyte present in bodily fluids. The dry fluorescence biosensor strip comprises a sample receptacle and a dry detection membrane. The sample receptacle receives a sample of one of the bodily fluids. The dry detection membrane detects presence of the target analyte in the received sample based on fluorescence induced on the dry detection membrane. Fluorescent signals are emitted from the dry detection membrane on induction of fluorescence. A fluorometer quantifies measurable properties of the target analyte based on the emitted fluorescent signals. The dry fluorescence biosensor strip may further comprise a filtration membrane for filtering the received sample. The filtered sample migrates from the filtration membrane to the dry detection membrane. The dry detection membrane may then detect presence of the target analyte in the filtered sample.

Abstract translation: 本文公开了用于快速检测存在于体液中的目标分析物的干荧光生物传感器条。 干荧光生物传感器条包括样品容器和干检测膜。 样品容器接收一种体液的样品。 干检测膜基于在干检测膜上诱导的荧光检测接收样品中目标分析物的存在。 在诱导荧光时，从干检测膜发出荧光信号。 荧光计基于发射的荧光信号量化目标分析物的可测量性质。 干荧光生物传感器条可以进一步包括用于过滤所接收的样品的过滤膜。 过滤的样品从过滤膜迁移到干检测膜。 然后，干检测膜可以检测过滤样品中目标分析物的存在。