公开(公告)号：US07858612B2

公开(公告)日：2010-12-28

申请号：US12449371

申请日：2008-12-17

申请人： Tomohisa Ninomiya ,  Takashi Shishikura ,  Mitsuhiro Uchida ,  Sho Takahata ,  Yukari Hoshina ,  Ken-ichi Kawano

发明人： Tomohisa Ninomiya ,  Takashi Shishikura ,  Mitsuhiro Uchida ,  Sho Takahata ,  Yukari Hoshina ,  Ken-ichi Kawano

IPC分类号： A61K31/5517

CPC分类号： C07D487/04 ,  A61K31/4192 ,  A61K31/55

摘要： The present invention relates to a method for maintaining the remission of or treating inflammatory bowel diseases, which comprises administering a maintenance therapeutically effective amount or a therapeutically effective amount of 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzoazepine, a prodrug thereof, or a pharmaceutically acceptable salt thereof to a mammal, wherein the prodrug is 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine. The method according to the present invention is effective in the maintenance therapy and therapy of the inflammatory bowel diseases and has few side effects. Particularly, the method according to the present invention may exhibit strong maintenance therapeutic and therapeutic effects, even on severe cases having resistance to the conventional therapeutics.

摘要翻译： 本发明涉及一种维持炎症性肠病的缓解或治疗的方法，其包括给予维持治疗有效量或治疗有效量的7,8-二甲氧基-4（5H），10-二氧代-1H-1 ，2,3-三唑并[4,5-c] [1]苯并吖庚因，其前药或其药学上可接受的盐，其中前药为2-（1-异丙氧羰基氧基-2-甲基丙基） 8-二甲氧基-4（5H），10-二氧代-2H-1,2,3-三唑并[4,5-c] [1]苯并吖庚因。 根据本发明的方法在炎症性肠病的维持治疗和治疗中是有效的，并且副作用很小。 特别地，即使对具有对常规疗法的抗性的严重病例，根据本发明的方法也可表现出很强的维持治疗和治疗效果。

公开(公告)号：US20100291070A1

公开(公告)日：2010-11-18

申请号：US12810459

申请日：2008-12-24

申请人： Masashi Kumagai ,  Jiro Tanaka ,  Hiroshi Nagaso ,  Tomohisa Ninomiya ,  Keiko Otsuka ,  Hirotomo Akabane ,  Takahisa Suzuki

发明人： Masashi Kumagai ,  Jiro Tanaka ,  Hiroshi Nagaso ,  Tomohisa Ninomiya ,  Keiko Otsuka ,  Hirotomo Akabane ,  Takahisa Suzuki

IPC分类号： A61K39/40 ,  C07K16/12 ,  C07K16/44 ,  C12N5/20 ,  A61K39/104 ,  A61K39/395 ,  A61P31/04 ,  A61P37/04

CPC分类号： C07K16/1214 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/21 ,  C07K2317/76 ,  G01N33/56911 ,  G01N2333/21

摘要： An object is to provide an antibody and a vaccine composition which have an ability to practically prevent or treat a Pseudomonas aeruginosa infection, and which can cope with the diversity of clinical isolates derived from patients infected with Pseudomonas aeruginosa. According to the present invention, an antibody against a PA1698 protein that is a type III secretion system component protein of Pseudomonas aeruginosa or against a peptide of the protein, and a vaccine composition comprising the protein or the peptide are provided.

摘要翻译： 目的是提供具有实际预防或治疗铜绿假单胞菌感染能力的抗体和疫苗组合物，其可以应付源自感染铜绿假单胞菌的患者的临床分离物的多样性。 根据本发明，提供了针对PA1698蛋白的抗体，其是铜绿假单胞菌的III型分泌系统组分蛋白或针对蛋白质的肽，以及包含所述蛋白质或肽的疫苗组合物。

公开(公告)号：US20100130475A1

公开(公告)日：2010-05-27

申请号：US12449371

申请日：2008-12-17

申请人： Tomohisa Ninomiya ,  Takashi Shishikura ,  Mitsuhiro Uchida ,  Sho Takahata ,  Yukari Hoshina ,  Ken-ichi Kawano

发明人： Tomohisa Ninomiya ,  Takashi Shishikura ,  Mitsuhiro Uchida ,  Sho Takahata ,  Yukari Hoshina ,  Ken-ichi Kawano

IPC分类号： A61K31/55 ,  A61P1/00

CPC分类号： C07D487/04 ,  A61K31/4192 ,  A61K31/55

摘要： The present invention relates to a pharmaceutical composition for preventing or treating inflammatory bowel diseases, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzoazepine, a prodrug thereof, preferably 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine as a prodrug, or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention is effective in the prophylaxis and therapy of the inflammatory bowel diseases and has few side effects. Particularly, the pharmaceutical composition according to the present invention may exhibit strong prophylactic and therapeutic effects even on severe cases having resistance to the conventional therapeutics.

摘要翻译： 本发明涉及一种用于预防或治疗炎症性肠病的药物组合物，其包含7,8-二甲氧基-4（5H），10-二氧代-1H-1,2,3-三唑并[4,5-c] [ 1]苯并吖庚因，其前药，优选2-（1-异丙氧羰基氧基-2-甲基丙基）-7,8-二甲氧基-4（5H），10-二氧代-2H-1,2,3-三唑并[4,5- c] [1]苯并吖庚因作为前药，或其药学上可接受的盐。 根据本发明的药物组合物在预防和治疗炎症性肠病方面是有效的，并且副作用很少。 特别地，本发明的药物组合物即使对具有对常规疗法的抗性的严重病例也可能表现出强的预防和治疗效果。